French National Sentinel Survey of Antiretroviral Drug Resistance in Patients With HIV-1 Primary Infection and in Antiretroviral-Naive Chronically Infected Patients in 2001-2002

Descamps, Diane; Chaix, Marie‐Laure; André, Patrice; Brodard, Véronique; Cottalorda, J.; Deveau, Christiane; Harzic, M.; Ingrand, D.; Izopet, Jacques; Kohli, Évelyne; Masquelier, Bernard; Mouajjah, Said; Palmer, Pierre; Pellegrin, Isabelle; Plantier, Jean‐Christophe; Poggi, Cécile; Ranger-Rogez, Sylvie; Ruffault, Annick; Schneider, Véronique; Signori-Schmück, Anne; Tamalet, Catherine; Wirden, Marc; Rouzioux, Christine; Brun‐Vézinet, Françoise; Meyer, Laurence; Costagliola, Dominique

doi:10.1097/01.qai.0000155201.51232.2e

Cited by 104 publications

(53 citation statements)

References 38 publications

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“…Our results indicate a higher proportion of non-B subtypes than was previously observed in France (15% in 1996-1998 and 33% in 2001) that is probably a consequence of immigration from Africa [3,5,23]. However, the proportion of subtype B infections among African persons living in France is substantial (19%) and contrasts with the finding that subtype B is very rare in sub-Saharan Africa table 5on [24][25][26].…”

Section: Discussioncontrasting

confidence: 56%

Monitoring the Dynamics of the HIV Epidemic Using Assays for Recent Infection and Serotyping among New HIV Diagnoses: Experience after 2 Years in France

et al. 2007

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Background. New tools to better monitor dynamics of human immunodeficiency virus (HIV) transmission are needed.Methods. National surveillance of newly HIV diagnoses included the collection of dried serum spots to identify both recent infections (!6 months) and HIV serotypes. Multivariate analyses were used to identify factors associated with recent infection and infection with non-B subtypes.Results. Between 2003 and March 2005, 7902 new HIV diagnoses were reported. The overall proportion of recent infections was 24.9% (95% confidence interval, 23.8%-26.0%) and was highest among men who have sex with men (MSM; 46%). Recent infection was associated with being an MSM, !30 years old, of French nationality, and living in Paris. Nearly half of newly HIV-1 diagnoses were with non-B subtypes. The highest proportion of non-B infections was reported among African heterosexual persons (81%), but important proportions were reported among French heterosexual persons (34%) and MSM (12%). Being infected by a non-B subtype was independently associated with being African, !30 years old, heterosexual, and living in Paris. The proportion of HIV-2 infection was 1.9%, and 11 cases of HIV-1 group O infection were identified, mainly among West Africans.Conclusions. There is evidence of high levels of HIV transmission among MSM in France and transmission of non-B subtypes within the indigenous French population.

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Section: Discussioncontrasting

confidence: 56%

Monitoring the Dynamics of the HIV Epidemic Using Assays for Recent Infection and Serotyping among New HIV Diagnoses: Experience after 2 Years in France

et al. 2007

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“…The geographic patterns of the M group subtypes are continuously changing in response to human population migrations and active transmission networks, thus inciting constant vigilance. Although several reports suggest that the prevalences of non-B subtypes are increasing in western Europe (12)(13)(14)(15)(16)(17), the B subtype remains the most prevalent. Portugal contrasts with the rest of western Europe in its distribution of HIV-1 subtypes.…”

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confidence: 99%

Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of Non-B and Non-G Subtypes

et al. 2015

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The existing data support Portugal as the western European country with the highest HIV-1 subtype diversity. However, detailed phylogenetic studies of Portuguese HIV-1 epidemics are still scarce. Thus, our main goal was to analyze the phylodynamics of a local HIV-1 infection in the Portuguese region of Minho. Molecular epidemiological analysis was applied to data from 289 HIV-1-infected individuals followed at the reference hospital of the province of Minho, Portugal, at which isolated viruses had been sequenced between 2000 and 2012. Viruses of the G (29.1%) and B (27.0%) subtypes were the most frequent, followed by recombinant forms (17.6%) and the C (14.5%), F1 (7.3%), and A1 (4.2%) subtypes. Multinomial logistic regression revealed that the odds of being infected with the A1 and F1 subtypes increased over the years compared with those with B, G, or C subtypes or recombinant viruses. As expected, polyphyletic patterns suggesting multiple and old introductions of the B and G subtypes were found. However, transmission clusters of non-B and non-G viruses among native individuals were also found, with the dates of the most recent common ancestor estimated to be in the early 2000s. Our study supports that the HIV-1 subtype diversity in the Portuguese region of Minho is high and has been increasing in a manner that is apparently driven by factors other than immigration and international travel. Infections with A1 and F1 viruses in the region of Minho are becoming established and are mainly found in sexually transmitted clusters, reinforcing the need for more efficacious control measures targeting this infection route.

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“…It is thus necessary to study subtype-specific genotypic determinants of HIV-1 tropism. The CRF02-AG recombinant subtype predominates in West Africa (10) and accounts for an increasing proportion of cases in Western Europe, notably in France (6,14). Various proportions of CXCR4-using viruses have been reported in subtype CRF02-AG-infected patients (2,15,16), but little is known about the genotypic determinants of HIV-1 tropism for subtype CRF02-AG viruses.…”

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Genotypic Prediction of Human Immunodeficiency Virus Type 1 CRF02-AG Tropism

et al. 2009

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We assessed the performance of genotypic algorithms for predicting the tropism of human immunodeficiency virus type 1 coreceptor usage in 52 patients infected with the CRF02-AG subtype. The combined criteria of the 11/25 and net charge rules accurately detected CXCR4-using CRF02-AG viruses, whereas the Geno2pheno tool lacked sensitivity and the position-specific scoring matrix (PSSM) tool WebPSSM lacked specificity.

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French National Sentinel Survey of Antiretroviral Drug Resistance in Patients With HIV-1 Primary Infection and in Antiretroviral-Naive Chronically Infected Patients in 2001-2002

Abstract: In France, the frequency of HIV-1 resistance in untreated patients was not significantly higher in 2001-2002 than in previous surveys while the prevalence of non-B subtypes is increasing.

Cited by 104 publications

References 38 publications

Monitoring the Dynamics of the HIV Epidemic Using Assays for Recent Infection and Serotyping among New HIV Diagnoses: Experience after 2 Years in France

Monitoring the Dynamics of the HIV Epidemic Using Assays for Recent Infection and Serotyping among New HIV Diagnoses: Experience after 2 Years in France

Analysis of a Local HIV-1 Epidemic in Portugal Highlights Established Transmission of Non-B and Non-G Subtypes

Genotypic Prediction of Human Immunodeficiency Virus Type 1 CRF02-AG Tropism

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