Freezing of the intact rat stomach: An indication of the biologic potential of the technic

Effect of decreased levels of endogenous gastric tissue histamine on acid secretion and stress ulcer formation in the rat.

“…In parallel studies, Hanson and Brodie (1960) demonstrated a significant reduction in both acid secretion and ulcer formation when cholinergic blocking agents were administered simultaneously. Additionally, McFee and his associates (1963) noted that the incidence of stress ulcer formation in response to starvation and cold was reduced from 925% to 33.3 % following an episode of gastric freezing, a procedure which has been demonstrated to alter markedly the ability of the intact rat's stomach to secrete acid (Ritchie, Breen, and Wangensteen, 1966). These studies provide some evidence, albeit indirect, that acid peptic digestion probably plays at least a permissive role in the development of stress ulcer.…”

Studies on some Quaternary Compounds with an Inhibitory Effect on the Gastric Secretion of Rats

“…BRODIE & KUNDRATS (1964) noticed that a temperature fall of 2" caused a reduction of gastric secretion, and that the inhibitory action of morphine was proportional to its effect on temperature. RITCHIE (1967) showed that in rats, as in humans, the secretion can be greatly reduced for several weeks by a short-term, intense cooling down of the stomach.…”