Freeze-thawed muscle grafting for painful cutaneous neuromas

Thomas, Mahiban; Stirrat, A. N.; Birch, R; Glasby, M. A.

doi:10.1302/0301-620x.76b3.8175858

Cited by 28 publications

(6 citation statements)

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“…Partial or complete relieve of pain was achieved in 60% of the cases. 143 Calder and Norris used freeze-thawed skeletal muscle autografts for secondary reconstruction of 13 mixed motor/sensory (6 median and 7 ulnar) nerves in 12 patients. 144 Five patients achieved good sensory recovery, whereas motor recovery remained poor in all patients.…”

Section: Clinical Studiesmentioning

confidence: 99%

Use of Skeletal Muscle Tissue in Peripheral Nerve Repair: Review of the Literature

Meek¹,

Varejão

Geuna

2004

Tissue Engineering

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The management of peripheral nerve injury continues to be a major clinical challenge. The most widely used technique for bridging defects in peripheral nerves is the use of autologous nerve grafts. This technique, however, necessitates a donor nerve and corresponding deficit. Many alternative techniques have thus been developed. The use of skeletal muscle tissue as graft material for nerve repair is one example. The rationale regarding the use of the skeletal muscle tissue technique is the availability of a longitudinally oriented basal lamina and extracellular matrix components that direct and enhance regenerating nerve fibers. These factors provide superiority over other bridging methods as vein grafts or (non)degradable nerve conduits. The main disadvantages of this technique are the risk that nerve fibers can grow out of the muscle tissue during nerve regeneration, and that a donor site is necessary to harvest the muscle tissue. Despite publications on nerve conduits as an alternative for peripheral nerve repair, autologous nerve grafting is still the standard care for treatment of a nerve gap in the clinical situation; however, the use of the skeletal muscle tissue technique can be added to the surgeon's arsenal of peripheral nerve repair tools, especially for bridging short nerve defects or when traditional nerve autografts cannot be employed. This technique has been investigated both experimentally and clinically and, in this article, an overview of the literature on skeletal muscle grafts for bridging peripheral nerve defects is presented.

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Section: Clinical Studiesmentioning

confidence: 99%

Use of Skeletal Muscle Tissue in Peripheral Nerve Repair: Review of the Literature

Meek¹,

Varejão

Geuna

2004

Tissue Engineering

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“…Up to now, only few clinical studies have been published reporting the used of muscle fiber grafts for repairing nerve defects in patients. In a series of interesting clinical papers published in the first half of the Nineties, satisfactory functional recovery was reported in most patients after reconstruction of nerve defects up to 6 cm [52][53][54][55][56][57]. In spite of these positive clinical results, the use of nerve guides made of skeletal muscle alone did not spread among surgeons so far.…”

Section: Skeletal Musclementioning

confidence: 99%

Update on nerve repair by biological tubulization

Geuna¹,

Tos²,

Titolo³

et al. 2014

Journal of Brachial Plexus and Peripheral Nerve Injury

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Many surgical techniques are available for bridging peripheral nerve defects. Autologous nerve grafts are the current gold standard for most clinical conditions. In selected cases, alternative types of conduits can be used. Although most efforts are today directed towards the development of artificial synthetic nerve guides, the use of non-nervous autologous tissue-based conduits (biological tubulization) can still be considered a valuable alternative to nerve autografts. In this paper we will overview the advancements in biological tubulization of nerve defects, with either mono-component or multiple-component autotransplants, with a special focus on the use of a vein segment filled with skeletal muscle fibers, a technique that has been widely investigated in our laboratory and that has already been successfully introduced in the clinical practice.

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“…In the same case series, good functional recovery was reported in 7% of cases, whereas it was poor in 66% of patients. 2 Alternatively, functional recovery and pain control could be achieved by vein grafting, 3 freeze-thawed muscle grafts, 4 and artificial nerve guides. 5 Nerve grafting and functional reconstructions are usually contraindicated because of poor results in cases where multiple nerve lesions are observed, when a long time after denervation is ascertained, or when the 2 stumps are not eligible for functional reconstruction.…”

Section: Introductionmentioning

confidence: 99%