Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects

Basu, Arpita; Wilkinson, Marci; Penugonda, Kavitha; Simmons, Brandi; Betts, Nancy M.; Lyons, Timothy J.

doi:10.1186/1475-2891-8-43

Cited by 143 publications

(138 citation statements)

References 25 publications

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“…Results of many studies demonstrate the positive impact of dietary polyphenols on the level and composition of blood lipids [Jenkins et al, 2008;Basu et al, 2009;Jarosławska et al, 2011]. In the presented experiment, such an effect was observed for ET preparation produced via acetone extraction, whereas the preparation produced by water extraction did not Unauthenticated Download Date | 5/9/18 11:34 AM cause the beneficial reduction of cholesterol and/or triacylglycerols level in blood.…”

Section: Discussionmentioning

confidence: 57%

Physiological Properties of Dietary Ellagitannin-Rich Preparations Obtained from Strawberry Pomace Using Different Extraction Methods

Juśkiewicz¹,

Król²,

Kosmala³

et al. 2015

Polish Journal of Food and Nutrition Sciences

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The objective of this study was to establish the composition of strawberry preparations rich in ellagitannins obtained using water or acetone extraction (EF and EP preparation, respectively). Then, biological effect of these extracts was assessed in 4-wk nutritional experiment on Wistar rats. The preparations were applied in cholesterol-containing diets that had equal content of ellagitannins (0.03%). To measure animals response, parameters describing the caecal fermentation (ammonia and short-chain fatty acid concentrations, bacterial enzymes activity), blood serum lipoprotein profile, and TBARS content in selected tissues (heart, liver, kidney) were assessed. Apart from polyphenols, including ellagitannins (7.8 and 7.1%, respectively), the EF preparation contained high quantities of soluble dietary fibre and other carbohydrates (33.3 and 38.9%, respectively), whereas the EP preparation was characterised by 58.9% content of ellagitannins, no dietary fibre and a high content of proanthocyanidins (16.9%). In comparison to EF group, the dietary treatment with EP had a stronger effect on caecal environment as manifested by decreased digesta bulk, β-glucuronidase activity and total short-chain fatty acid concentration (P<0.05 vs. group C without supplementation). Both preparations lowered lipaemia and glycaemia. It could be concluded that more efficient acetone extraction of strawberry pomace increased the content of both ellagitannins and proanthocyanidins in the polyphenolic preparation, which caused a stronger inhibiting effect on caecal fermentation processes and at the same time lowered blood triacylglycerols and glucose level. Considering the equal content of ellagitannins in both supplemented diets, it may be speculated that the above effects were due to the presence of proanthocyanidin fraction.

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Section: Discussionmentioning

confidence: 57%

Physiological Properties of Dietary Ellagitannin-Rich Preparations Obtained from Strawberry Pomace Using Different Extraction Methods

Juśkiewicz¹,

Król²,

Kosmala³

et al. 2015

Polish Journal of Food and Nutrition Sciences

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“…Previous work has shown reduced fasting lipids and oxidative stress markers after strawberry consumption for 4 wk, suggesting adaptive responses reflective of favorable homeostatic shifts [16][17][18] . Research from non-strawberry sources of dietary polyphenols further supports this work showing changes in the expression of anti-oxidant genes [19][20][21] .…”

Section: Introductionmentioning

confidence: 90%

Attenuation of Meal-Induced Inflammatory and Thrombotic Responses in Overweight Men and Women After 6-Week Daily Strawberry (Fragaria) Intake

Ellis

Edirisinghe

Kappagoda

et al. 2011

JAT

101

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Aim: A pro-thrombotic, pro-inflammatory diet can play a causative role in atherosclerotic-cardiovascular diseases. Dietary intervention studies provide insight into their pathophysiological manifestations and opportunities for prevention and management. We previously showed in an acute-meal setting that a beverage containing polyphenolic-and antioxidant-rich strawberry (Fragaria) vs placebo attenuated postprandial (fed-state) increases in biomarkers of oxidative and inflammatory stress, and insulin concentrations, induced by a high carbohydrate/fat (HCF) meal. In the present study, we aimed to extend our findings and investigate hypotheses related to the effects of chronic/6-week (wk) strawberry consumption on HCF meal-induced increases in glucose, insulin, and indicators of inflammation and hemostasis. Methods: In a crossover design, 14 women and 10 men (mean age, BMI: 50.9 15 years, 29.2 2.3 kg/m 2 , respectively), were randomized to a 6-wk strawberry or placebo beverage followed by an HCF meal with assessments for 6-hours (h) postprandially. Results: HCF meal responses after 6-wk strawberry beverage showed significantly attenuated postprandial PAI-1 concentrations compared to the placebo (p 0.002); the difference was most notable at 6 h. The IL-1 response was attenuated with strawberry compared to the placebo (p 0.05). IL-6 attenuation was apparent but non-significant; IL-6 rose significantly from baseline to 6 h after the HCF meal following a placebo (p ≤ 0.01), although it remained relatively flat following the strawberry beverage from fasting to 6 h. No significant treatment-related differences were apparent for platelet aggregation, hsCRP, TNF-, insulin, or glucose. Conclusion: These data are the first to suggest that regular consumption of strawberry, a polyphenolic-and antioxidant-rich fruit, may provide protection from HCF meal-induced increases in fibrinolytic and inflammatory factors in at-risk men and women.

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“…Longerterm strawberry supplementation has been shown to improve multiple CVD risk factors (16)(17)(18)(19)(20)(21)(22)(23)(24)(25), but less is known about the acute effects of strawberries in the context of a fat-containing meal. A modest attenuation of the 6-h postprandial triglyceride, insulin, and oxidized LDL response was found in overweight hyperlipidemic adults when 10 g freeze-dried strawberry powder was incorporated into a meal with 30 g total fat (26,27).…”

Section: Introductionmentioning

confidence: 99%

Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

Richter

Skulas‐Ray

Gaugler

et al. 2017

The American Journal of Clinical Nutrition

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Background: Postprandial dysmetabolism-an exaggerated spike in triglycerides, glucose, and insulin-increases cardiovascular disease risk by inducing oxidative stress, inflammation, and endothelial dysfunction. Polyphenol-rich foods may blunt these effects when they are incorporated into a high-fat, calorie-dense meal. Strawberries are a rich source of polyphenols, but there is little research on their postprandial effects. Objective: This study was designed to investigate the effect of adding 40 g freeze-dried strawberry powder (w1 lb. or 0.45 kg fresh strawberries) to a high-fat (50 g total fat) meal on postprandial vascular function, as well as triglyceride, glucose, and insulin responses. Design: Healthy, overweight or obese [mean 6 SEM body mass index (in kg/m 2 ): 31 6 0.5] adults (mean 6 SEM age: 28 6 2 y; 17 men and 13 women) consumed a control meal and a strawberry meal in a randomized crossover design. Testing sessions were separated by $1 wk for men and w1 mo for women to control for hormonal variations. Blood samples were obtained before the meal and 0.5, 1, 2, and 4 h after the meal. Central blood pressure and arterial stiffness indexes were measured at baseline and 2 and 4 h postmeal with the use of pulse waveform analysis. Results: There were no significant differences between the strawberry and control meals for any outcomes. Consumption of either meal significantly decreased the augmentation index at 2 and 4 h (P , 0.002) and significantly increased triglycerides, insulin, and glucose at all time points (P , 0.001) relative to baseline. Conclusions: The strawberry intervention did not alter vascular function or attenuate postprandial metabolic derangements in triglycerides, glucose, or insulin relative to the control meal. Additional research is needed to clarify whether strawberries or other polyphenol-rich interventions improve postprandial responses, and future studies should take into account the acute meal-induced improvements in measures of vascular function. This trial was registered at clinicaltrials.gov as NCT01989637.Am J Clin Nutr 2017;105:313-22.

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Freeze-dried strawberry powder improves lipid profile and lipid peroxidation in women with metabolic syndrome: baseline and post intervention effects

Cited by 143 publications

References 25 publications

Physiological Properties of Dietary Ellagitannin-Rich Preparations Obtained from Strawberry Pomace Using Different Extraction Methods

Physiological Properties of Dietary Ellagitannin-Rich Preparations Obtained from Strawberry Pomace Using Different Extraction Methods

Attenuation of Meal-Induced Inflammatory and Thrombotic Responses in Overweight Men and Women After 6-Week Daily Strawberry (Fragaria) Intake

Incorporating freeze-dried strawberry powder into a high-fat meal does not alter postprandial vascular function or blood markers of cardiovascular disease risk: a randomized controlled trial

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