Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations

Khoramgah, Maryam Sadat; Ranjbari, Javad; Abbaszadeh, Hojjat-Allah; Mirakabad, Fatemeh Sadat Tabatabaei; Hatami, Shadie; Hosseinzadeh, Simzar; Ghanbarian, Hossein

doi:10.34172/bi.2020.10

Cited by 32 publications

(27 citation statements)

References 63 publications

(71 reference statements)

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“…The potential of mesenchymal stem cells is being actively studied in various in vitro and in vivo works to investigate the possibilities for the treatment of a wide range of pathologies, including bone, 9 cartilage, 10 and skin damage. The clinical efficacy of MSCs in the short term has been already demonstrated, however, the question of utmost importance is the efficacy and safety of MSC-based therapy in the long term.…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal stromal cells therapy alone does not lead to the complete restoration of the skin parameters in diabetic foot patients within a 3-year follow-up period

et al. 2021

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Introduction: Mesenchymal stromal cells (MSCs) administration is an effective option for the treatment of diabetic foot ulcers (DFUs). However, to date, studies assessing long-term outcomes and evaluating skin parameters after cell-based therapy are lacking. We presented the clinical outcomes of 3 patients, treated for DFUs with the bone marrow MSCs 3 years earlier. Methods: Ultrasound examination was used to compare collagen density and epidermal thickness in areas of healed ulcers in comparison with non-affected skin used as a control. Ultrasound and dermatoscopy were used to exclude neoplasm formation, to assess scar contracture and wound recurrence. Results: In all patients, no ulcer recurrence was detected, which was lower than the expected 60% rate of re-ulceration in diabetic patients in a 3-year period (OD [odds ratio] = 0.095, P = 0.12). No neoplasm formation, no contracture of hypertrophic scar, and adjacent tissue were registered. Collagen ultrasound density was decreased by 57% (P = 0.053) and epidermal thickness was increased by 72% (P = 0.01) in the area of healed ulcers in all patients. Conclusion: MSCs therapy alone did not result in the complete restoration of the skin parameters within a 3-year period. MSCs may represent important adjuvant to the therapy, however, other novel approaches are required to achieve better results.

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Section: Discussionmentioning

confidence: 99%

Mesenchymal stromal cells therapy alone does not lead to the complete restoration of the skin parameters in diabetic foot patients within a 3-year follow-up period

et al. 2021

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“…The scaffolds exhibited randomly oriented nanofibers of 2 and 650 nm and compressive moduli of 620 and 130 kPa, respectively. Human ADSCs seeded on stiffer PTFE/PVA/GO scaffolds revealed a significant elevation in ALP activity, calcium deposition, and osteogenic related genes expression as compared to the softer scaffold without graphene oxide [192].…”

Section: Vinyl Polymersmentioning

confidence: 96%

Effect of Polymeric Matrix Stiffness on Osteogenic Differentiation of Mesenchymal Stem/Progenitor Cells: Concise Review

et al. 2021

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Mesenchymal stem/progenitor cells (MSCs) have a multi-differentiation potential into specialized cell types, with remarkable regenerative and therapeutic results. Several factors could trigger the differentiation of MSCs into specific lineages, among them the biophysical and chemical characteristics of the extracellular matrix (ECM), including its stiffness, composition, topography, and mechanical properties. MSCs can sense and assess the stiffness of extracellular substrates through the process of mechanotransduction. Through this process, the extracellular matrix can govern and direct MSCs’ lineage commitment through complex intracellular pathways. Hence, various biomimetic natural and synthetic polymeric matrices of tunable stiffness were developed and further investigated to mimic the MSCs’ native tissues. Customizing scaffold materials to mimic cells’ natural environment is of utmost importance during the process of tissue engineering. This review aims to highlight the regulatory role of matrix stiffness in directing the osteogenic differentiation of MSCs, addressing how MSCs sense and respond to their ECM, in addition to listing different polymeric biomaterials and methods used to alter their stiffness to dictate MSCs’ differentiation towards the osteogenic lineage.

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“…Meanwhile the roughness of pore structure and the specific surface area of the composite also increased due to the embedding of phase change microcapsules. 49 The water absorption curves of various samples are shown in Fig. 3.…”

Section: Resultsmentioning

confidence: 99%

Simultaneous phase change energy storage and thermoresponsive shape memory properties of porous poly(vinyl alcohol)/phase change microcapsule composites

Shi

Liu

et al. 2021

Polymer International

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Porous poly(vinyl alcohol) (PVA)/phase change microcapsule composites with shape memory properties were prepared by physical foaming, cycles of freezing-thawing and freeze drying. The effects of phase change microcapsules on pore structure, phase change energy storage capacity, thermal stability, crystallinity, mechanical properties, shape memory properties and water absorption and retention of the porous composites were investigated. With an increase of the proportion of phase change microcapsules, the pore density, pore size and water absorption and retention of the porous composite materials were decreased, while the phase change energy storage performance was improved and ΔH m was up to 31.22 J g −1 . The phase change energy storage of the porous composites was stable even after 50 phase transition cycles. Meanwhile, the thermal stability of the porous composites was also not affected by the addition of phase change microcapsules. The entanglement of PVA molecular chains in the porous composites was affected by the microcapsules embedded in the matrix of PVA during freezingthawing cycles, resulting in a change of crystallinity and mechanical properties of the porous composites. The porous composites with phase change energy storage capacity also showed good shape memory performance with shape recovery rate of 100% even after multiple deformation, which was expected to expand the multi-field application of dual-functional materials.

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Freeze-dried multiscale porous nanofibrous three dimensional scaffolds for bone regenerations

Cited by 32 publications

References 63 publications

Mesenchymal stromal cells therapy alone does not lead to the complete restoration of the skin parameters in diabetic foot patients within a 3-year follow-up period

Mesenchymal stromal cells therapy alone does not lead to the complete restoration of the skin parameters in diabetic foot patients within a 3-year follow-up period

Effect of Polymeric Matrix Stiffness on Osteogenic Differentiation of Mesenchymal Stem/Progenitor Cells: Concise Review

Simultaneous phase change energy storage and thermoresponsive shape memory properties of porous poly(vinyl alcohol)/phase change microcapsule composites

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