Freeze-Dried Composite Tendon Allografts: An Experimental Study

Cameron, Ronald R.; Conrad, Robert N.; Sell, Kenneth W.; Latham, Wilbur D.

doi:10.1097/00006534-197101000-00009

Cited by 27 publications

(12 citation statements)

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“…Deep freezing and freeze-drying of allografts have been shown to reduce antigenicity of grafts and minimize the damaging effect of free radicals because they are less active at these temperatures. 9,21,32,35 These procedures cannot achieve terminal sterilization and thus eliminate the risk of disease transmission, but they may contribute to a higher safety of grafts by reducing risk of graft-to-host reactions without compromising graft integrity.…”

Section: Discussionmentioning

confidence: 99%

Effect of Electron Beam Irradiation on Biomechanical Properties of Patellar Tendon Allografts in Anterior Cruciate Ligament Reconstruction

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Effect of Electron Beam Irradiation on Biomechanical Properties of Patellar Tendon Allografts in Anterior Cruciate Ligament Reconstruction

et al. 2010

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“…As an alternative, intrasynovial tendon allografts have been suggested [3,6,16]. One recent study concluded that the biomechanical advantages for tendon reconstruction using autografts over devitalized allograft were minimal, but this study evaluated an extrasynovial tendon injury, which raises some questions about its clinical applicability [10].…”

Section: Introductionmentioning

confidence: 96%

Surface Treatment of Flexor Tendon Autograft and Allograft Decreases Adhesion Without an Effect of Graft Cellularity: A Pilot Study

Karabekmez

Zhao

2012

Clinical Orthopaedics &Amp; Related Research

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Background Flexor tendon grafting is often required to reconstruct a failed tendon repair. Previous reports have demonstrated flexor grafts coated with lubricants such as carbodiimide derivatized hyaluronic acid (cd-HA) decrease adhesion formation and improve digit function. However, whether this surface modification would affect graft adhesion and cellularity is unknown. Questions/Purposes Adhesion score and the cellularity of the graft of untreated and cd-HA surface-modified autograft and allograft tendons were studied using a canine forepaw in vivo model. Methods The peroneus longus tendons (n = 6) and flexor digitorum profundus tendons (n = 8) were used as extrasynovial autograft and intrasynovial allograft, respectively. The flexor digitorum profundus (FDP) tendons in the second and fifth digits in each dog were reconstructed with one digit treated with cd-HA and the other treated with saline as a control. Six weeks after surgery, the grafted tendons were harvested for histological evaluation with hematoxylin and eosin staining. During dissection, the adhesions were observed and scored. Results The adhesion score was greatest in the extrasynovial autograft without surface modification and the least in the intrasynovial allograft with surface modification. Autograft tendons had a higher cell density than the allografts regardless of surface treatment. Cd-HA graft treatment did not affect cellularity when compared with controls. Conclusions Our observations suggest surface modification of a tendon graft with cd-HA decreased the adhesion formation without altering the cellularity in either autologous or allograft tendon. We therefore presume this surface modification would not adversely affect graft healing.

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“…However, due to the limitations in the availability of suitable intrasynovial autografts, an extrasynovial allograft is often used for hand reconstruction. Lyophilized flexor tendons have been reported as a satisfactory substitute for injured tendon (Cameron et al, 1971; Peacock and Madden, 1967). Potenza (1964) and Potenza and Melone (1978) showed that lyophilized implanted flexor tendons in canine model can function very well and are histologically well tolerated.…”

Section: Discussionmentioning

confidence: 99%

Compressive properties of cd-HA-gelatin modified intrasynovial tendon allograft in canine model in vivo

Ikeda

Zhao

Chen

et al. 2011

Journal of Biomechanics

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Although we sometimes use the intrasynovial tendon allograft as a donor, the gliding ability of allograft prepared by lyophilization is significantly decreased. The gliding ability of the grafted tendon after tendon reconstruction is very important because the high gliding resistance causes more adhesion and leads to poor clinical results. We recently revealed that tendon surface treatment with a carbodiimide derivatized HA (cd-HA)-gelatin mixture for intrasynovial tendon allograft significantly improved its gliding ability. The purpose of this study was to investigate whether this cd-HA-gelatin treatment affects the tendon mechanical property or not. A total of 40 flexor digitorum profundus (FDP) tendons from canines were evaluated for compressive property by using indentation test. Indentation stiffness was measured for normal tendon, rehydrated tendon after lyophilization, rehydrated tendon after lyophilization that was implanted 6 weeks in vivo, and cd-HA treated rehydrated tendon after lyophilization that was implanted 6 weeks in vivo. The results for all groups showed no significant difference in the tendon compressive properties. The findings of these results demonstrate that cd-HA treatment for intrasynovial tendon allograft is an excellent method to improve the tendon gliding ability after lyophilization without changing the compressive property of donor tendon.

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Freeze-Dried Composite Tendon Allografts: An Experimental Study

Cited by 27 publications

References 0 publications

Effect of Electron Beam Irradiation on Biomechanical Properties of Patellar Tendon Allografts in Anterior Cruciate Ligament Reconstruction

Effect of Electron Beam Irradiation on Biomechanical Properties of Patellar Tendon Allografts in Anterior Cruciate Ligament Reconstruction

Surface Treatment of Flexor Tendon Autograft and Allograft Decreases Adhesion Without an Effect of Graft Cellularity: A Pilot Study

Compressive properties of cd-HA-gelatin modified intrasynovial tendon allograft in canine model in vivo

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