Freeze Dried Chitosan/ Poly-(Glutamic Acid) Microparticles for Intestinal Delivery of Lansoprazole

Singh, Mangla Nand; Yadav, Hemant Kumar; Ram, Munshi; Shivakumar, H. G.

doi:10.2174/156720112798376041

Cited by 11 publications

(7 citation statements)

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“…The self-assembling polymer or block/graft copolymer method and the ionic gelation method are the most common methods for γ-PGA nanoparticle formulation [27]. To date, all of the formulated γ-PGA particle studies have been in nanoscale size, apart from three studies which investigated the fabrication of γ-PGA particles in micro scale size [46,47,48]. …”

Section: Poly-γ-glutamic Acid (γ-Pga) As An Antimicrobial Coating mentioning

confidence: 99%

“…With decreasing pH, the degradation rate and the instability of lansoprazole is increased [47]. In the stomach, the degradation of lansoprazole occurs because of to the acidic environment, leading to a reduction in clinical effect and bioavailability.…”

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

“…In the GI tract, the pH environment is different, as the stomach has an acidic environment and the small intestine has an alkaline environment. In order to increase the stability of microparticles, a compact structure of carriers was developed to work in a wider range of pH, sodium tripolyphosphate and magnesium were introduced to crosslink CH physically with γ-PGA in such investigations [47,89,90]. …”

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

“…The most abundant ion in living cells is Mg 2+ . Singh et al, 2012 [47] prepared microparticles that are pH-sensitive, and subsequently complexed with CH, TTP and MgSO 4 , and utilised with γ-PGA in different ratios. The research concluded that microparticles are free flowing with a round shape; many chitosan properties were altered with the addition of γ-PGA, leaving γ-PGA-CH micro/nanoparticles, a very useful drug delivery application carrier.…”

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

“…The research concluded that microparticles are free flowing with a round shape; many chitosan properties were altered with the addition of γ-PGA, leaving γ-PGA-CH micro/nanoparticles, a very useful drug delivery application carrier. Acid-dependent drugs, including lansoprazole, can now be expressed in the form of an enteric covered capsule with chitosan/γ-poly-glutamic acid microparticles in them, used as a continued drug release delivery method [47,89,90]. …”

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

See 4 more Smart Citations

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Khalil

Burns

Radecka

et al. 2017

IJMS

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In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as biocompatibility with tissue and cells. γ-PGA is a naturally occurring biopolymer produced by several gram-positive bacteria that, due to its biodegradable, non-toxic and non-immunogenic properties, has been used successfully in the medical, food and wastewater industries. Moreover, its carboxylic group on the side chains can offer an attachment point to conjugate antimicrobial and various therapeutic agents, or to chemically modify the solubility of the biopolymer. The unique characteristics of γ-PGA have a promising future for medical and pharmaceutical applications. In the present review, the structure, properties and micro/nanoparticle preparation methods of γ-PGA and its derivatives are covered. Also, we have highlighted the impact of micro/nanoencapsulation or immobilisation of antimicrobial agents and various disease-related drugs on biodegradable γ-PGA micro/nanoparticles.

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Section: Poly-γ-glutamic Acid (γ-Pga) As An Antimicrobial Coating mentioning

confidence: 99%

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

Section: Medical Applications Of γ-Pga-based Micro/nanoparticlesmentioning

confidence: 99%

See 3 more Smart Citations

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Khalil

Burns

Radecka

et al. 2017

IJMS

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HPLC Determination of Lansoprazole and Method Application for the Formulation Development of Enteric‐coated Lansoprazole Pellets

Tsai

Cham

2015

J Chinese Chemical Soc

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The aim of this study was to develop a validated HPLC method for the determination of lansoprazole in dissolution medium and pellets. For the formulation development, we investigated the role of 2‐hydroxypropyl‐β‐cyclodextrin (HPβCD) on the dissolution of enteric‐coated pellets of lansoprazole prepared by the solution layering technique using a fluid bed coater. Dissolution results demonstrated the coating using Acryl‐Eze protected the formulations from releasing lansoprazole in acid medium for the first 2 h, and the addition of HPβCD improved the dissolution performance by 189%, compared with the group without HPβCD. The DSC analysis displaced an absence of the endothermic peak for the lyophilized products lansoprazole and HPβCD, and FTIR analysis demonstrated the band broadening, shifting or disappearance compared to the spectra of the physical mixture, which indicated the formation of the inclusion complex between lansoprazole and HPβCD. This study has developed a validated HPLC method to measure lansoprazole in test media and pellets, which was applied successfully to the formula tion development of enteric‐coated pellets.

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Biochemical hallmarks-targeting antineoplastic nanotherapeutics

Han,

Dong,

Zhu

et al. 2024

Bioactive Materials

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Freeze Dried Chitosan/ Poly-(Glutamic Acid) Microparticles for Intestinal Delivery of Lansoprazole

Cited by 11 publications

References 0 publications

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

Bacterial-Derived Polymer Poly-y-Glutamic Acid (y-PGA)-Based Micro/Nanoparticles as a Delivery System for Antimicrobials and Other Biomedical Applications

HPLC Determination of Lansoprazole and Method Application for the Formulation Development of Enteric‐coated Lansoprazole Pellets

Biochemical hallmarks-targeting antineoplastic nanotherapeutics

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