Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer

Bluemel, Christina; Schnelzer, Andreas; Okur, Asli; Ehlerding, Alexandra; Paepke, Stefan; Scheidhauer, Klemens; Kiechle, Marion

doi:10.1007/s00259-013-2473-0

Cited by 76 publications

(49 citation statements)

References 14 publications

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“…The RT patient used in this study had to be removed and replaced during the transfer from the Department of Nuclear Medicine to the operation theater. To overcome this shortcoming, one might use a different method of coregistration, for example, by using multiple small metal balls that are not susceptible to deformation or by implementing the concept of intraoperative freehandSPECT (6)(7)(8). FreehandSPECT may help to correct for errors caused by tissue deformation as a result of surgical manipulation.…”

Section: Navigationmentioning

confidence: 99%

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

et al. 2016

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With the introduction of the hybrid tracer indocyanine green (ICG)-99m Tc-nanocolloid, a direct relation between preoperative imaging and intraoperative fluorescence guidance was established. However, fluorescence guidance remains limited by its superficial nature. This study evaluated the feasibility of a nuclear medicinebased navigation concept that allowed intraoperative positioning of a fluorescence camera (FC) in the vicinity of preoperatively defined ICG-99m Tc-nanocolloid containing sentinel nodes (SNs). Methods: Five patients with penile cancer scheduled for SN biopsy were injected with ICG-99m Tc-nanocolloid followed by preoperative SPECT/CT imaging. The navigation device was used to provide a real-time augmented reality overlay of the SPECT/CT images and video output of the FC. This overlay was then used for FC navigation.

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Section: Navigationmentioning

confidence: 99%

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

et al. 2016

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“…For example, imaging technology is a non-invasive method for evaluating whole lymph nodes, which is mainly based on the diagnosis of lymph nodes invaded by tumor cells. [29][30][31] …”

Section: Tumor Lymphatic Metastasismentioning

confidence: 99%

Progress of Lymph-Targeted Contrast Agents and Their Application in Diagnosis of Tumor Lymphatic Metastasis

Zhang¹,

Wang²,

Cheng³

et al. 2017

General Chemistry

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Lymph node metastasis is an important aspect for tumor metastasis, which accounts for a majority of cancer death. Non-invasive imaging techniques play a more important role than traditional lymph node biopsy for diagnosis of metastatic lymph nodes. However, non-specific information of lymph node such as size and morphology could only be obtained in traditional imaging techniques, which always bring about mission detection. Thus, lymph-targeted contrast agents are attracting much interest. Presently, most contrast agents are based on the mechanism of passive targeting, which could be affected by the number and function of macrophages in the lymph nodes. Therefore, it is beneficial to study the tumor lymphatic metastases through developing new lymph-targeted contrast agents, which could bring fresh prospect for tumor diagnosis and treatment. The paper reviews the progress of lymph-targeted contrast agents and their diagnosis technology for cancer.

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“…Creating a Fh SPECT image is shown in The surgeon traces the radioactive material using the hand-held gamma camera to identify the breast SLN [30]. reported a >89.7% SLN detection rate using the conventional gamma probe and Fh SPECT [4]. In a mobile hybrid Fh SPECT system, the tumor density is staged, enabling registration of a Fh SPECT image on the US plane as shown in Figure 7.…”

Section: Freehand Single-photon Emission Computed Tomography (Fh Spect)mentioning

confidence: 99%

Breast sentinel lymph node biopsy with imaging towards minimally invasive surgery

Joseph

Oepen

Friebe

2017

Biomedical Engineering / Biomedizinische Technik

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Breast sentinel lymph nodes are still commonly assessed through complete lymph node dissections, which is a time-consuming and radical approach because the nodes are difficult to identify. To prevent false diagnosis and achieve accurate results, minimally invasive, imageguided procedures are applied and constantly improved. The purpose of this paper is to present the currently used imaging modalities ultrasound, fluorescence, single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) and hybrid imaging methods and comparing their effectiveness for breast sentinel lymph node biopsy. A definition for an ideal imaging system combining efficient minimally invasive techniques with workflow considerations is also discussed. As a conclusion, upcoming imaging methods and their future outlook with areas of advancement are presented.

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Freehand SPECT for image-guided sentinel lymph node biopsy in breast cancer

Abstract: FhSPECT is a highly sensitive modality for intraoperative detection of SLNs, resulting in the identification of a higher number of SLNs than conventional gamma probe detection.

Cited by 76 publications

References 14 publications

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

Toward (Hybrid) Navigation of a Fluorescence Camera in an Open Surgery Setting

Progress of Lymph-Targeted Contrast Agents and Their Application in Diagnosis of Tumor Lymphatic Metastasis

Breast sentinel lymph node biopsy with imaging towards minimally invasive surgery

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