Score-based diffusion models have shown promising results in unpaired image-to-image translation (I2I). However, the existing methods only perform unpaired I2I in pixel space, which requires high computation costs. To this end, we propose guiding stochastic differential equations in latent space (Latent-SDE) that extracts domain-specific and domain-independent features of the image in the latent space to calculate the loss and guides the inference process of a pretrained SDE in the latent space for unpaired I2I. To refine the image in the latent space, we propose a latent time-travel strategy that increases the sampling timestep. Empirically, we compare Latent-SDE to the baseline of the score-based diffusion model on three widely adopted unpaired I2I tasks under two metrics. Latent-SDE achieves state-of-the-art on Cat $$\rightarrow $$
→
Dog and is competitive on the other two tasks. Our code will be freely available for public use upon acceptance at https://github.com/zhangXJ147/Latent-SDE.