Free/Total PSA (F/T ratio) kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy

Gregorakis, Alkiviades K.; Malovrouvas, Dimitrios; Stefanakis, S.; Petraki, Konstantina; Scorilas, Andreas

doi:10.1016/j.cccn.2005.03.027

Cited by 18 publications

(18 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Free PSA and tPSA have been shown to have different half-lives (approximately 2–24 h for fPSA and 2.2–3 days for tPSA) [34]–[36], which may explain why the PSA increase in these non-surgical manipulations has been shown to be short-lived. Our study demonstrated that the manipulation of the prostate caused by cycling affected tPSA to a similar magnitude as ejaculation, DRE and cystoscopy.…”

Section: Discussionmentioning

confidence: 99%

Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

Mejak¹,

Bayliss

Hanks³

2013

PLoS ONE

View full text Add to dashboard Cite

ObjectivesTo investigate whether bicycle riding alters total prostate-specific antigen (tPSA) serum concentrations in healthy older men.Methods129 male participants, ranging in age from 50 to 71 years (mean 55 years), rode in a recreational group bicycle ride of between 55 and 160 kilometers. Blood samples for tPSA analysis were drawn within 60 minutes before starting, and within 5 minutes after completing the ride. The pre-cycling and post-cycling tPSA values were log transformed for normality and compared using paired t-tests. Linear regression was used to assess the relationship between changes in tPSA with age and distance cycled.ResultsBicycle riding caused tPSA to increase by an average of 9.5% (95% CI = 6.1–12.9; p<0.001) or 0.23 ng/ml. The number of participants with an elevated tPSA (using the standard PSA normal range cut-off of 4.0 ng/ml) increased from two pre-cycle to six post-cycle (or from five to eight when using age-based normal ranges). Univariate linear regression analysis revealed that the change in tPSA was positively correlated with age and the distance cycled.ConclusionsCycling causes an average 9.5% increase in tPSA, in healthy male cyclists ≥50 years old, when measured within 5 minutes post cycling. We considered the increase clinically significant as the number of participants with an elevated PSA, according to established cut-offs, increased post-ride. Based on the research published to date, the authors suggest a 24–48 hour period of abstinence from cycling and ejaculation before a PSA test, to avoid spurious results.

show abstract

Section: Discussionmentioning

confidence: 99%

Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

Mejak¹,

Bayliss

Hanks³

2013

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Prostate‐Specific Antigen (PSA) is an important diagnostic tool for detection, staging and monitoring of patients with prostate cancer . Following radical prostatectomy (RP), PSA is an excellent tumour marker with a high sensitivity and specificity for the diagnosis of recurrent or residual disease . PSA monitoring has led to the identification of men with recurrent disease following RP in the absence of symptoms, signs or conventional imaging evidence of locally recurrent or metastatic disease.…”

Section: Introductionmentioning

confidence: 99%

“…1 Following radical prostatectomy (RP), PSA is an excellent tumour marker with a high sensitivity and specificity for the diagnosis of recurrent or residual disease. 2 PSA monitoring has led to the identification of men with recurrent disease following RP in the absence of symptoms, signs or conventional imaging evidence of locally recurrent or metastatic disease. In this setting, the detection yields of imaging techniques such as bone scan (BS), abdomino-pelvic CT and MRI are, at best, modest.…”

Section: Introductionmentioning

confidence: 99%

A pilot study of the utility of choline PET–CT in prostate cancer biochemical relapse following radical prostatectomy

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Consequently, a variety of molecular biomarkers, including other kallikrein members, could play a potential role in the clinical diagnosis of prostate cancer. ( 11–15 )…”

mentioning

confidence: 99%

“…Consequently, a variety of molecular biomarkers, including other kallikrein members, could play a potential role in the clinical diagnosis of prostate cancer. (11)(12)(13)(14)(15) The human tissue kallikreins (KLKs) comprise a subgroup of secreted serine proteases that represent the largest contiguous cluster of protease genes in the human genome and are located in the chromosome locus 19q13.4. (16,17) The process of alternative splicing seems to be a rather usual event within the kallikrein family; approximately 70 alternatively spliced variants of kallikrein genes have been indentified up to date.…”

mentioning

confidence: 99%

Expression analysis and study of the KLK15 mRNA splice variants in prostate cancer and benign prostatic hyperplasia

et al. 2010

Self Cite

View full text Add to dashboard Cite

Prostate cancer is the most commonly diagnosed malignancy in male populations in the Western world. The KLK15 gene, the newest member of the kallikrein family, is expressed in the prostate gland. The purpose of this study is the expression analysis and the clinical evaluation of the KLK15 mRNA spliced variants in prostate cancer (CaP) and benign prostatic hyperplasia (BPH) patients. Total RNA was isolated from 104 CaP and BPH tissue specimens. After testing the quality of the RNA, cDNA was produced by reverse transcription, and PCR was performed for the amplification of the KLK15 mRNA transcripts. GAPDH and HPRT genes were used as endogenous controls. Our data revealed that mRNA spliced variants of KLK15 were differentially expressed in prostate tissue specimens. Analysis of data showed a statistically significant (P < 0.001) increase in the frequency of overexpression of KLK15 transcripts encoding for both the active isoform and for the isoform 3 in CaP compared to BPH samples. Furthermore, KLK15 transcripts were found to be highly expressed in more aggressive tumors (P = 0.017). These results suggest that KLK15 expression analysis could be employed as a valuable tool for the discrimination between BPH and CaP tissue specimens and as an unfavorable prognostic marker for prostate cancer. (Cancer Sci 2010; 101: 693-699) P rostate cancer (CaP) is the most common non-skin male malignancy, accounting for almost 33% of all cancer incidents. Also, it is the second-most common cause of cancer-related deaths in most Western countries.(1,2) Although many risk factors, such as alterations in androgen biosynthesis and metabolism, and diet and chronic inflammation, have been associated with the disease, the etiology of prostate cancer remains uncertain.(1,3,4) The most common form of the disease is sporadic prostate cancer, which is expected to be developed by non-random somatic genome alterations such as loss or gain of chromosomal regions (6q, 7q, 8p), abnormal DNA methylation, mutations of oncogenes (EGFR, MYC) and tumor suppressor genes (NXK3.1, GSTP1), and alterations regarding the androgen receptor (AR).(2,5-7) AR is an intracellular ligand-dependent transcription factor, which plays an essential role in the survival and growth of prostate cells, as well as in the initiation and the progression of prostate tumors. As a result, the disease treatment aims at the regulation and manipulation of the AR metabolic pathway. However, AR function evolves as the cell changes toward a clinical androgen-depletion independent state. (8,9) Recently published data show that benign prostatic hyperplasia (BPH) occurs to about 8% of men aged from 31 to 40 years, to one-quarter of men in their 50s, to one-third of men in their 60s, to about half of all men aged 80 years or older and increases to about 90% by the ninth decade of life. (10) Since the discovery of prostate-specific antigen (PSA) also known as, kallikrein (KLK) 3 routine PSA testing has become the mainstay of prostate cancer detection.(11) However, PSA lacks diagnostic sp...

show abstract

Free/Total PSA (F/T ratio) kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy

Cited by 18 publications

References 25 publications

Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

Long Distance Bicycle Riding Causes Prostate-Specific Antigen to Increase in Men Aged 50 Years and Over

A pilot study of the utility of choline PET–CT in prostate cancer biochemical relapse following radical prostatectomy

Expression analysis and study of the KLK15 mRNA splice variants in prostate cancer and benign prostatic hyperplasia

Contact Info

Product

Resources

About