Free-swimming submersible testbed (EAVE WEST) / Paul J. Heckman, Jr.

Heckman, P.

doi:10.5962/bhl.title.47195

Cited by 15 publications

(10 citation statements)

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“…Using a variety of behavioural tasks, these effects have been consistently proven under physiological conditions and in different models of pharmacologically-induced cognitive deficits or in animal models of human pathologies, including Alzheimer's disease (Richter et al, 2013;Hansen III and Zhang, 2015;Heckman et al, 2015). Interestingly, it has been recently reported that the promnesic effects of PDE4-I need several hours to manifest, again indicating the role of cAMP in switching a transient form of memory into a more stable one (Akkerman et al, 2014;Bollen et al, 2014).…”

Section: Type 4 Phosphodiesterases Ltp and Memory: Spotlight On Pde4dmentioning

confidence: 99%

Phosphodiesterase 4D: an enzyme to remember

Ricciarelli

Fedele

2015

British J Pharmacology

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Cyclic adenosine monophosphate (cAMP) is one of the second messengers critically involved in the molecular mechanisms underlying memory formation. In the CNS, the availability of cAMP is tightly controlled by phosphodiesterase 4 (PDE4), a family of enzymes that degrades the cyclic nucleotide to inactive AMP. Among the different PDE4 isoforms, in the last few years PDE4D has been hogging the limelight due to accumulating evidence for its crucial role in cognitive processes, which makes this enzyme a promising target for therapeutic interventions in a variety of pathological conditions characterized by memory impairment, such as Alzheimer's disease. In this article, we review the role of the cAMP signal transduction pathway in memory formation with a particular focus on the recent progress in PDE4D research. AbbreviationsCNG, cyclic nucleotide gated; CREB, cAMP responsive element binding protein; Epac, exchange protein directly activated by

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Section: Type 4 Phosphodiesterases Ltp and Memory: Spotlight On Pde4dmentioning

confidence: 99%

Phosphodiesterase 4D: an enzyme to remember

Ricciarelli

Fedele

2015

British J Pharmacology

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“…[4] Independent of whether the mobility is provided by a ciliary organ or a muscle-based effector system, [5,6] coordinating navigation in a context where motor action is generated as a response to current (or recent history of the) sensory information constitutes the basis of sensorimotor integration. [7][8][9] Although sensorimotor computation commonly leads to navigation (as well as other forms of motor control including vocalization and vocal communication [10][11][12][13][14] ), we refrain from discussing the circuits of navigation, which are reviewed elsewhere. [15][16][17][18][19][20] Here, we focus on the networks that have evolved to provide such sensorimotor control to address general principles of sensorimotor computation from a neural circuit perspective, with the focus being on Caenorhabditis elegans (C. elegans).…”

Section: Introductionmentioning

confidence: 99%

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Hughes

Celikel

2019

BioEssays

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From single-cell organisms to complex neural networks, all evolved to provide control solutions to generate context-and goal-specific actions. Neural circuits performing sensorimotor computation to drive navigation employ inhibitory control as a gating mechanism as they hierarchically transform (multi)sensory information into motor actions. Here, the focus is on this literature to critically discuss the proposition that prominent inhibitory projections form sensorimotor circuits. After reviewing the neural circuits of navigation across various invertebrate species, it is argued that with increased neural circuit complexity and the emergence of parallel computations, inhibitory circuits acquire new functions. The contribution of inhibitory neurotransmission for navigation goes beyond shaping the communication that drives motor neurons, and instead includes encoding of emergent sensorimotor representations. A mechanistic understanding of the neural circuits performing sensorimotor computations in invertebrates will unravel the minimum circuit requirements driving adaptive navigation.

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“…The productions of gravitino from decay of moduli, inflation, and Polonyi fields have also been discussed[29][30][31][32][33][34][35][36][37].…”

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confidence: 99%

Gauge mediation scenario with hidden sector renormalization in MSSM

2010

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We study the hidden sector effects to the mass renormalization of a simplest gauge-mediated supersymmetry breaking scenario. We point out that possible hidden sector contributions render the soft scalar masses smaller, resulting in drastically different sparticle mass spectrum at low energy. In particular, in the 5 +5 minimal gauge mediated supersymmetry breaking with high messenger scale (that is favored by the gravitino cold dark matter scenario), we show that stau can be the next lightest superparticle for moderate values of hidden sector self coupling. This provides a very simple theoretical model of long-lived charged next lightest superparticles, that imply distinctive signals in ongoing and upcoming collider experiments.

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Free-swimming submersible testbed (EAVE WEST) / Paul J. Heckman, Jr.

Cited by 15 publications

References 0 publications

Phosphodiesterase 4D: an enzyme to remember

Phosphodiesterase 4D: an enzyme to remember

Prominent Inhibitory Projections Guide Sensorimotor Computation: An Invertebrate Perspective

Gauge mediation scenario with hidden sector renormalization in MSSM

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