Free sterols of the historically important green algal                     genera, Acetabularia and Acicularia (Polyphysaceae): a modern                     interpretation

Dahmen, Aaron; Houle, Hannah M.; Leblond, Jeffrey D.

doi:10.1127/algol_stud/2017/0290

Cited by 2 publications

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“…Four other minor Δ 5 sterols occurred in all five species: 24-methylcholesterol (24α/24R = campesterol 36 , 24β/24S = 22-dihydrobrassicasterol 38 ), 24-ethylcholesta-5,22 E -dienol (24α/24S = stigmasterol 39 , 24β/24R = poriferasterol 40 ), 24-methylcholesta-5,22 E -dienol (24α/24S = crinosterol 41 , 24β/24R = brassicasterol 42 ), and 24-ethylidenecholesterol, which was tentatively assigned by the authors as the Δ 24(28)Z isomer = isofucosterol 44 . Among the TMS-derivatized sterols of Acetabularia caliculus , 24-ethylcholest-7-enol 46 / 47 was identified ( Figure 4 , Table 1 ) [ 52 ]. Prior studies had also identified cholesterol and 24-methylenecholesterol 45 in cultures of Acetabularia mediterranea , suggested by the authors to potentially be a result of differences in algal cultivation.…”

Section: Phylogenic and Ecological Insightsmentioning

confidence: 99%

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Microbial Sterolomics as a Chemical Biology Tool

Haubrich

2018

Molecules

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Metabolomics has become a powerful tool in chemical biology. Profiling the human sterolome has resulted in the discovery of noncanonical sterols, including oxysterols and meiosis-activating sterols. They are important to immune responses and development, and have been reviewed extensively. The triterpenoid metabolite fusidic acid has developed clinical relevance, and many steroidal metabolites from microbial sources possess varying bioactivities. Beyond the prospect of pharmacognostical agents, the profiling of minor metabolites can provide insight into an organism’s biosynthesis and phylogeny, as well as inform drug discovery about infectious diseases. This review aims to highlight recent discoveries from detailed sterolomic profiling in microorganisms and their phylogenic and pharmacological implications.

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Section: Phylogenic and Ecological Insightsmentioning

confidence: 99%

“…These nearly identical sets of sterols from the five species, with a large separation in their geographical origin, illustrate a lack of divergence in sterol composition. It was thus hypothesized that these sterols represent an ancient biochemical trait within the photosynthetic lineage [ 52 ].…”

Section: Phylogenic and Ecological Insightsmentioning

confidence: 99%