Free Radical-Scavenging Properties of Olive Oil Polyphenols

Visioli, Francesco; Bellomo, Giorgio; Galli, Cláudio

doi:10.1006/bbrc.1998.8735

Cited by 666 publications

(435 citation statements)

References 30 publications

Supporting

Mentioning

408

Contrasting

Unclassified

Order By: Relevance

“…This group of radicals (superoxide, hydroxyl and lipoid peroxides) may interact with biological systems in a clearly cytotoxic manner. In this respect, flavonoids and phenols have been shown to possess an important antioxidant activity toward these radicals, which is principally based on the redox properties of their phenolic hydroxyl groups and the structural relationships between different parts of their chemical structure (Bors & Saran, 1987;Visioli, Bellomo, & Galli, 1998a, Visioli, Bellosta, & Galli, 1998b. Free radicals and their uncontrolled production, in fact, are responsible for several pathological processes, such as certain tumours (prostate and colon cancers) (Keys, 1995) and coronary heart disease (Lipworth, Martinez, Angell, Hsien, & Trichopoulos, 1997).…”

Section: Introductionmentioning

confidence: 99%

Total phenols, ascorbic acid, β-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities

et al. 2007

View full text Add to dashboard Cite

The antioxidant activities of three Portuguese wild edible mushroom species, Leucopaxillus giganteus, Sarcodon imbricatus, andAgaricus arvensis, were evaluated. Methanolic extracts were screened for their reducing power, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicalscavenging capacity, inhibition of erythrocytes hemolysis and antioxidant activity using the b-carotene linoleate model system. The amounts of ascorbic acid, b-carotene and lycopene found in the mushroom extracts were very low. Otherwise, the high contents of phenolic compounds might account for the good antioxidant properties found in all species. L. giganteus had the highest content of phenols and proved to be the most active, presenting lower EC 50 values in all the antioxidant activity assays.

show abstract

Section: Introductionmentioning

confidence: 99%

Total phenols, ascorbic acid, β-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities

et al. 2007

View full text Add to dashboard Cite

show abstract

“…This group of reactive species (superoxide, hydroxyl and lipidic peroxides) may interact with biological systems in a clearly cytotoxic manner, being responsible for several pathological processes, such as certain tumours (prostate and colon cancers) (Keys, 1995) and coronary heart disease (Lipworth, Martinez, Angell, Hsien, & Trichopoulos, 1997). In this respect, olive flavonoids, phenols and oleuropeosides have been shown to possess important antioxidant activity towards these radicals, which is principally based on the redox properties of their phenolic hydroxyl groups and the structural relationships between different parts of their chemical structure (Bors & Saran, 1987;Visioli, Bellomo, & Galli, 1998;Visioli, Bellosta, & Galli, 1998).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and phenolic contents of Olea europaea L. leaves sprayed with different copper formulations

et al. 2007

View full text Add to dashboard Cite

Olive trees (Olea europaea L. Cv. Cobrançosa) from the northeast of Portugal were sprayed with three different copper formulations [bordeaux mixture (copper sulphate + calcium hydroxide À 20% Cu), copper hydroxide (40% Cu) and copper oxychloride (50% Cu)] to control olive fungal diseases. The residues of copper in olive leaves, harvested at different times, were evaluated by atomic absorption spectrometry. At all the collection times, treated olive leaves had significantly higher copper contents, compared to the control. The different copper amounts in pesticide formulations lowered the leaves contents in total phenols and hence their antioxidant properties. Olive leaves sprayed with copper oxychloride possessed the highest copper levels and the lowest content in phenols, which influenced its antioxidant activity (higher EC 50 values for reducing power, scavenging effect on DPPH radicals and inhibition of erythrocyte hemolysis). Leaves without copper residues proved to be a good natural source of antioxidants, giving values comparable to the reference compounds.

show abstract

“…Several studies report the antioxidant properties of HT in biological systems (Cornwell and Ma 2008;D'Angelo et al 2005;Hamden et al 2009;Jemai et al 2009;Manna et al 1999;O'Dowd et al 2004;Visioli et al 1998). However, the mechanisms leading to the antioxidant properties of HT are not completely understood.…”

Section: Discussionmentioning

confidence: 99%

“…Hydroxytyrosol (2-(3,4-dihydroxyphenyl) ethanol) is a hydrophilic polyphenol commonly found in olives; olive oil is a common ingredient of the Mediterranean diet (Rodriguez et al 2009). The use of olive oil in the diet is believed to be associated with a lower incidence of cancer and cardiovascular diseases in the Mediterranean population (Fabiani et al 2008;Visioli et al 1998). Potential benefits of hydroxytyrosol (HT) are also suggested for preventing diabetes, vascular damage, and influenza (Jemai et al 2009;Jemai et al 2008;Yamada et al 2009).…”

Section: Introductionmentioning

confidence: 99%

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan

Sarsour

Kumar

Kalen

et al. 2011

AGE

View full text Add to dashboard Cite

Chronological lifespan (CLS) is defined as the duration of quiescence in which normal cells retain the capacity to reenter the proliferative cycle. This study investigates whether hydroxytyrosol (HT), a naturally occurring polyphenol found in olives, extends CLS in normal human fibroblasts (NHFs). Quiescent NHFs cultured for a long duration (30-60 days) lose their capacity to repopulate. Approximately 60% of these cells exit the cell cycle permanently; a significant increase in the doubling time of the cell population was observed. CLS was extended in quiescent NHFs that were cultured in the presence of HT for 30-60 days. HT-induced extension of CLS was associated with an approximately 3-fold increase in manganese superoxide dismutase (MnSOD) activity while there was no change in copper-zinc superoxide dismutase, catalase, or glutathione peroxidase protein levels. Quiescent NHFs overexpressing a dominant-negative mutant form of MnSOD failed to extend CLS. HT suppressed ageassociated increase in mitochondrial ROS levels. Results from spectroscopy assays indicate that HT in the presence of peroxidases can undergo catechol-semiquinone-quinone redox cycling generating superoxide, which in a cellular context can activate the antioxidant system, e.g., MnSOD expression. These results demonstrate that HT extends CLS by increasing MnSOD activity and decreasing age-associated mitochondrial reactive oxygen species accumulation.

show abstract

Free Radical-Scavenging Properties of Olive Oil Polyphenols

Cited by 666 publications

References 30 publications

Total phenols, ascorbic acid, β-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities

Total phenols, ascorbic acid, β-carotene and lycopene in Portuguese wild edible mushrooms and their antioxidant activities

Antioxidant activity and phenolic contents of Olea europaea L. leaves sprayed with different copper formulations

MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan

Contact Info

Product

Resources

About