Free radical scavenging and skin penetration of troxerutin and vitamin derivatives

Kessler, Marc; Ubeaud, G.; Walter, Tatjana; F, Sturm; Jung, L.

doi:10.1080/09546630260199505

Cited by 35 publications

(15 citation statements)

References 48 publications

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“…TX being an antioxidant significantly reduced oxidative damage to proteins, thereby decreasing AOPP levels in circulation. Several studies have noted that TX is a potent antioxidant, and it has been shown to scavenge oxygen-derived free radicals in vitro at various concentrations [41][42][43][44]. Recently, the antioxidative effect of TX has been demonstrated against ultraviolet B radiation in human HaCaT keratinocyte cells [45].…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice

Radika

Priyadarshini

et al. 2015

Mol Cell Biochem

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A previous study from our laboratory showed that troxerutin (TX) provides cardioprotection by mitigating lipid abnormalities in a high-fat high-fructose diet (HFFD)-fed mice model of metabolic syndrome (MS). The present study aims to investigate the reversal effect of TX on the fibrogenic changes in the myocardium of HFFD-fed mice. Adult male Mus musculus mice were grouped into four and fed either control diet or HFFD for 60 days. Each group was divided into two, and the mice were either treated or untreated with TX (150 mg/kg bw, p.o) from the 16th day. HFFD-fed mice showed marked changes in the electrocardiographic data. Increased levels of myocardial superoxide, p22phox subunit of NADPH oxidase, transforming growth factor (TGF), smooth muscle actin (α-SMA), and matrix metalloproteinases (MMPs)-9 and -2, and decreased levels of tissue inhibitors of MMPs-1 and -2 were observed. Furthermore, degradation products of troponin I and myosin light chain-1 were observed in the myocardium by immunoblotting. Rise in collagen was observed by hydroxyproline assay, while fibrotic changes were noticed by histology and Western blotting. Hypertrophy of cardiomyocytes and myocardial calcium accumulation were also observed in HFFD-fed mice. TX treatment exerted cardioprotective and anti-fibrotic effects in HFFD-fed mice by improving cardiac contractile function, reducing superoxide production and by favorably modifying the fibrosis markers. These findings suggest that TX could be cardioprotective through its antioxidant and antifibrogenic actions. This new finding could pave way for translation studies to human MS.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice

Radika

Priyadarshini

et al. 2015

Mol Cell Biochem

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“…Studies indicate that troxerutin is safe and effective in elderly patients (Marhic 1991 ) and pregnant women (Wijayanegara et al 1992 ). Troxerutin scavenges oxygen-derived free radicals (Kessler et al 2002 ; Wenisch and Biffignandi 2001 ). During head and neck cancer radiotherapy, administration of a mixture of coumarin and troxerutin conferred protection to the oral mucosa and salivary glands (Grotz et al 2001 ).…”

Section: Naturally Occurring Radioprotectorsmentioning

confidence: 99%

Pharmacology of natural radioprotectors

et al. 2018

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Radiotherapy is one of the most efficient ways to treat cancer. However, deleterious effects, such as acute and chronic toxicities that reduce the quality of life, may result. Naturally occurring compounds have been shown to be non-toxic over wide dose ranges and are inexpensive and effective. Additionally, pharmacological strategies have been developed that use radioprotectors to inhibit radiation-induced toxicities. Currently available radioprotectors have several limitations, including toxicity. In this review, we present the mechanisms of proven radioprotectors, ranging from free radical scavenging (the best-known mechanism of radioprotection) to molecular-based radioprotection (e.g., upregulating expression of heat shock proteins). Finally, we discuss naturally occurring compounds with radioprotective properties in the context of these mechanisms.

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“…Intravenous administration of agents like a-TOS are impractical for humans and other modes, such as transdermal delivery may be more useful and, also, safer [98] (Neuzil et al, unpublished data). Another problem that may be encountered is the potential systemic toxicity of some analogues of vitamin E. While a-TOS has been found nontoxic, the much more apoptogenic a-TAM causes severe neurotoxicity when injected into the mouse peritoneum.…”

Section: Anticancer Activity Of Vitamin E Analoguesmentioning

confidence: 96%

Vitamin E analogues as anticancer agents: Lessons from studies with α-tocopheryl succinate

Wang

Dong

Zhao

et al. 2006

Mol. Nutr. Food Res.

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The new millennium has witnessed considerable decrease in a number of previously fatal pathologies, largely due to the advancement in molecular medicine and modern approaches to treatment. In spite of this success, neoplastic disease remains a serious problem due to several reasons. These include an exceedingly high variability of cancer cells even within the same type of tumour. Cancer cells, albeit of clonal origin, mutate so that they escape established treatments, resulting in the fatal outcome of current therapies. Moreover, there are types of cancer, such as mesotheliomas, that cannot be treated at present. A novel group of clinically interesting anticancer drugs has been a recent focus in the literature that hold substantial promise as selective anticancer drugs. These compounds, epitomised by alpha-tocopheryl succinate, comprise redox-silent analogues of vitamin E that have been shown to suppress several types of cancer in animal models, including breast, colon and lung cancer as well as mesotheliomas and melanomas, while being nontoxic to normal cells and tissues. It is now proven that the strong anticancer effect of vitamin E analogues stems from their propensity to induce selective apoptosis in malignant cells. The results point to the novel group of vitamin E analogues as promising agents applicable to different types of tumours.

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Free radical scavenging and skin penetration of troxerutin and vitamin derivatives

Abstract: Using a stripping method, it was shown that the three substances, incorporated in a pharmaceutical preparation, permeated through human epidermis. Thus, this association can improve skin care products for preventing free radical-mediated damage.

Cited by 35 publications

References 48 publications

RETRACTED ARTICLE: Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice

RETRACTED ARTICLE: Troxerutin reverses fibrotic changes in the myocardium of high-fat high-fructose diet-fed mice

Pharmacology of natural radioprotectors

Vitamin E analogues as anticancer agents: Lessons from studies with α-tocopheryl succinate

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