Free radical scavenging and anti-oxidative activities of an ethanol-soluble pigment extract prepared from fermented Zijuan Pu-erh tea

Fan, Jiang Ping; Fan, Chong; Dong, Wen Min; Gao, Baoyu; Yuan, Wei; Gong, Jia Shun

doi:10.1016/j.fct.2013.06.047

Cited by 31 publications

(25 citation statements)

References 24 publications

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“…Relative indicators like SOD, MDA, GSH-PX and so on were analyzed in sixty patients before and after one month treatment with induction therapy (Mehdi WA et al, 2013). In Fan JP et al (2013)'s study, they evaluated the free radical scavenging and anti-oxidative activities of an ethanol-soluble pigment extract prepared from fermented Zijuan Pu-erh tea. Their final results suggested that the extract has excellent free radical scavenging and anti-oxidative properties by increasing the activity of SOD in cells and decreasing the concentration of MDA (Fan JP et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In Fan JP et al (2013)'s study, they evaluated the free radical scavenging and anti-oxidative activities of an ethanol-soluble pigment extract prepared from fermented Zijuan Pu-erh tea. Their final results suggested that the extract has excellent free radical scavenging and anti-oxidative properties by increasing the activity of SOD in cells and decreasing the concentration of MDA (Fan JP et al, 2013). In a study on pu-erh tea aqueous extracts lowering atherosclerotic risk factors in a rat hyperlipidemia model, Hou Y et al (2009) confirmed that compared to the hyperlipidmic control group, activities of SOD and GSH-PX in serum were significantly elevated in pu-erh tea-treated groups while levels of MDA decreased in the same groups.…”

Section: Discussionmentioning

confidence: 99%

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Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (17), 7389-7394 IntroductionChemotherapy is one of the major means for malignancy. It seeks to shrink tumors, decrease cancerrelated symptoms, advance quality of life, lengthen life spans of patients, and so on. Many studies have shown the effectiveness and feasibility of chemotherapy for cancers species involving the lung, pancreas, liver, large intestine, and so on. Conversely, treatment with anticancer drugs can also do harm to patients' normal tissues and organs, and those toxicities may lead to a worsened quality of life and shortened survival.Cisplatin (cis-diamminedichloroplatinumⅡ, CDDP) is one of the main chemotherapeutics, which is widely used for the treatment of various malignant solid tumors such as ovarian, lung, testicular and head and neck cancers (Pfister et al., 2010;Dimri et al., 2013; Dua et al., 2013;Besse et al., 2014 AbstractBackground: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Zheng¹,

Wang²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

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“…Pu-erh tea contains various polyphenols which provide health promoting functions like antioxidation, anti-atherogenesis, and anticancer , or act against cigarette-induced osteogenic damage (Holzer et al, 2012). For instance, one study exhibited the excellent free radical scavenging and antioxidative properties of fermented Zijuan Pu-erh tea (Fan et al, 2013), while another study showed the strong anticancer and antiangiogenesis effects of Pu-erh tea (Zhao, Song, Kim, Lee, & Park, 2013).…”

Section: Introductionmentioning

confidence: 98%

Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh black tea extract supplementation for quinocetone-treated Sprague-Dawley rats

Wang

Yang

et al. 2015

Journal of Functional Foods

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“…Another fermentation product, an extract of Zijuan Pu-erh tea, revealed an elevated antioxidant activity in vascular endothelial cells exposed to oxidative stress probably related to a different concentration of bioactive compounds such as polyphenols [77] . The same extract showed antiangiogenetic effects on HUVECs and anticancer activity on HT-29 cells [78] .…”

Section: Fermented Food: a New Class Of Nutraceuticals?mentioning

confidence: 99%

Nutraceuticals and cardiovascular risk: potential role of EPCs modulation

Russo

Lucchesi

Longo

et al. 2015

Stem Cell Transl Investig

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According to WHO cardiovascular diseases (CVDs) are the first cause of death in the world: more people die annually from CVDs than from any other cause. Vascular endothelium plays a pivotal role in the onset and progression of these pathologies and cardiovascular risk factors are frequently associated to the levels of endothelial progenitor cells (EPCs), bone marrow-derived circulating progenitors for the endothelial lineage. Since EPCs not only preserve vascular endothelium homeostasis, but might directly participate to re-endothelization and neovascularization, these cells represent an emerging protagonist in vascular competency and as such a cell model of great interest. An unhealthy diet is one of the main cardiovascular risk factor, while there is a great interest in the potential protective effects of "nutraceuticals", food-derived compounds that exert beneficial effects on human and animal health. The characterization of the endothelial effects of different nutraceuticals may provide fresh insights into their potential role in CVDs prevention. Several studies have already showed the protective effects of natural antioxidants on EPCs levels and functionality; some examples are resveratrol, catechin and folic acid. Fermentation has recently shown interesting roles in cardiovascular prevention since this process gave origin to a new class of foods, rich in bioactive compounds, the fermented foods. Consumption of fermented legumes and cereals, but also fermented beverages (such as beer and wine) was found to protect endothelial function through both lipid-lowering, as well anti-inflammatory and antioxidative mechanisms. Little is known about the effects of fermentation-derived nutraceuticals on EPCs. Given the important role of this cardiovascular biomarker, further analysis in this field can improve opportunities for CVDs prevention and treatment. Vascular endothelium and EPCs: new insightsFor many years vascular endothelium has been considered a mere physical barrier between blood and underlying tissues; recent studies have demonstrated new and interesting roles of endothelium in vascular health [1] .Endothelial cells composing this monolayer have therefore paracrine, endocrine and autocrine functions, by secreting several factors with vasodilatory and antiproliferative effects, such as endothelium-derived hyperpolarization factor (EDHF), nitric oxide (NO) and prostacyclin (PGI 2 ), and others inducing vasoconstrictor response, for instance endothelin-1 (ET-1), angiotensin II and reactive oxygen species (ROS) [2] . These evidences make the vascular endothelium a multifunctional unit that regulates vascular homeostasis by REVIEW

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Free radical scavenging and anti-oxidative activities of an ethanol-soluble pigment extract prepared from fermented Zijuan Pu-erh tea

Cited by 31 publications

References 24 publications

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh black tea extract supplementation for quinocetone-treated Sprague-Dawley rats

Nutraceuticals and cardiovascular risk: potential role of EPCs modulation

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