Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods

Pothitirat, W; Chomnawang, Mullika Traidej; Supabphol, Roongtawan; Gritsanapan, Wandee

doi:10.3109/13880200903062671

Cited by 60 publications

(50 citation statements)

References 13 publications

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“…The part of the Mangosteen from where the drug is taken, is due to dried pericarp and its preparation. From the data of the studies, pharmacological properties are indeed attributed to the dry extract obtained from the standardized pericarp in active constituents (Pothitirat et al, ; Asasutjarit et al, ).…”

Section: Discussionmentioning

confidence: 99%

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

et al. 2016

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Several studies have shown that xanthones obtained from Garcinia Mangostana (GM) have remarkable biological activities. α-mangostin (α-MG) is the main constituent of the fruit hull of the GM. Several findings have suggested that SIRT-1, a nuclear histone deacetylase, could influence cellular function by the inhibition of NF-kB signaling. ROS can inhibit SIRT-1 activity by initiating oxidative modifications on its cysteine residues, and suppression of SIRT-1 enhances the NF-κB signaling resulting in inflammatory responses. The goals of the present study were to evaluate the quantity of α-MG in the methanolic extract of GM (Vithagroup Spa) and to investigate the activity of this xanthone in U937 cell line and in human monocytes from responsive to inflammatory insult analyzing the possible changes on the activation of SIRT-1 protein via NF-Kb. Cells were treated with the methanolic extract of GM and/or LPS. The chromatographic separation of α-MG was performed by an HPLC analysis. EX 527, a specific SIRT-1 inhibitor, was used to determine if SIRT-1/NfkB signaling pathway might be involved in α-MG action on cells. Our results show that α-MG inhibits p65 acetylation and down-regulates the pro-inflammatory gene products as COX-2, iNOS via SIRT-1 activation. Cells treated with EX 527 showed an up-regulation of NFkB acetylation and an over expression of inducible enzymes and their product of catalysis (NO and PGE2). These results suggest that α-MG may be useful for the development of alternative pharmacological strategies aimed at reducing the inflammatory process. J. Cell. Physiol. 231: 2439-2451, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

et al. 2016

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“…The extract from Soxhlet extraction using 50% ethanol also promoted the lowest effective concentration that gives half-maximal response (EC50) 12.84 ± 0.08 µg/ml tested by DPPH-scavenging assay. The extract of 95% ethanol from Soxhlet extraction also promoted the lowest MIC against P. acnes, 7.81 µg/ml (Pothitirat et al, 2010). The investigation on the solvent that would yield the highest amount of α-mangostin was also performed and it was found that dichloromethane was the solvent that yielded 46.21 ± 2.46 % of α-mangostin w/w of extract.…”

Section: Panupon Khumsupan and Wandee Gritsanapanmentioning

confidence: 97%

“…Altogether, the anti-inflammatory (Chomnawang, Surassmo, Nukoolkarn, & Gritsanapan, 2007), antioxidant and antibacterial properties (Pothitirat, Chomnawang, Supabphol, & Gritsanapan, 2010) directly target acne's pathogeneses. When used in conjunction with an agent that promotes epidermal desquamation, α-mangostin could boast a potentially potent or even commercially beneficial active medicinal compound.…”

Section: Panupon Khumsupan and Wandee Gritsanapanmentioning

confidence: 99%

Anti-acne activity of Garcinia mangostana L.: A review

Khumsupan

Gritsanapan

2014

Plant Sci Today

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Garcinia mangostana L. or mangosteen of the Clusiaceae has traditionally been employed as medicinal drugs for decades. A plethora of compounds are responsible for a wide range of medicinal properties and biological activities. The ethanol extract of the mangosteen rind has been found to be anti-inflammatory, antioxidant and anti-acne-causing bacteria. Many research studies have confirmed its potency, with the ethanol extract of the rind being able to inhibit pro-inflammatory cytokines (TNF-α) at relatively low concentration. DPPH assay also revealed its potent radical scavenging activity. The compound responsible for the antibacterial activity, α-mangostin, was especially potent and one of the compounds responsible for the anti-bacterial activity.

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“…The loss of β cell number and function is associated with type I and II diabetes, and increasing the population has been hypothesized as a cure [69]. Although topically applied α mangostin clinically improved acne severity and inhibited growth of both Staphylococcus epidermidis and P. acnes in vitro [23,70,71], orally-administered extracts have not been tested as an acne treatment. The various activities suggest that Garcinia fruits may be worth studying for their effects on acne with oral supplementation.…”

Section: Edible Plants and Acnementioning

confidence: 99%

Edible Plants and Their Influence on the Gut Microbiome and Acne

Clark

Haas

Sivamani

2017

IJMS

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Acne vulgaris affects most people at some point in their lives. Due to unclear etiology, likely with multiple factors, targeted and low-risk treatments have yet to be developed. In this review, we explore the multiple causes of acne and how plant-based foods and supplements can control these. The proposed causative factors include insulin resistance, sex hormone imbalances, inflammation and microbial dysbiosis. There is an emerging body of work on the human gut microbiome and how it mediates feedback between the foods we eat and our bodies. The gut microbiome is also an important mediator of inflammation in the gut and systemically. A low-glycemic load diet, one rich in plant fibers and low in processed foods, has been linked to an improvement in acne, possibly through gut changes or attenuation of insulin levels. Though there is much interest in the human microbiome, there is much more unknown, especially along the gut-skin axis. Collectively, the evidence suggests that approaches such as plant-based foods and supplements may be a viable alternative to the current first line standard of care for moderate acne, which typically includes antibiotics. Though patient compliance with major dietary changes is likely much lower than with medications, it is a treatment avenue that warrants further study and development.

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Free radical scavenging and anti-acne activities of mangosteen fruit rind extracts prepared by different extraction methods

Cited by 60 publications

References 13 publications

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

A Novel Biological Role of α-Mangostin in Modulating Inflammatory Response Through the Activation of SIRT-1 Signaling Pathway

Anti-acne activity of Garcinia mangostana L.: A review

Edible Plants and Their Influence on the Gut Microbiome and Acne

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