Free radical scavenging activity of newly designed sesamol derivatives

Abstract

Chemical compounds with antioxidant behavior are recognized as efficient protectors against the harmful effects of reactive oxygen species (ROS) and other chemicals overproduced due to oxidative stress (OS). Sesamol has...

Current Trends in Computational Quantum Chemistry Studies on Antioxidant Radical Scavenging Activity

“…κ( T ) can significantly modulate reaction rate values between relatively similar reacting species, such as CH 3 OO • or OOH • . 118 It can be estimated using external software, for example Eyringpy. 258 The number of identical reaction paths, on the other hand, is reflected by σ and can be calculated by labeling all similar atoms and counting the number of different but equivalent configurations that can be formed by rotating, but not reflecting them.…”

“…This method has been already used successfully in numerous papers. 41 , 45 , 58 , 69 , 82 , 88 , 104 , 118 …”

“…When drawing conclusions from thermochemical data without considering kinetics, the Bell–Evans–Polanyi , principle, which states that the most exergonic processes have the lowest activation energies and are thus kinetically favored, is implicitly assumed to be followed . On the other hand, ignoring a reaction path due to difficulties in locating a transition state may result in a more significant error than accepting the given rule wihout its confirmation, especially if it was discovered to hold true for a structurally similar compounds . It has been recently evidenced that Gibbs free energy is actually proportional to the activation energy of hydrogen atom transfer, and hence reaction rate of this mechanism. ,, …”

“…Tunneling corrections (κ­( T )), also known in the literature as transmission coefficients (γ­( T )), are included, as is reaction path degeneracy (σ). κ­( T ) can significantly modulate reaction rate values between relatively similar reacting species, such as CH 3 OO • or OOH • . It can be estimated using external software, for example Eyringpy .…”

In-vitro antioxidant and in-vivo anti-aging with stress resistance on Caenorhabditis elegans of herbaceous peony stamen tea

“…This imbalance leads to the so-called oxidative stress phenomenon. [13] Due to the presence of several antioxidants, medicinal plants can scavenge these free radicals and protect human health against a variety of diseases. [10] Compared with synthetic antioxidants, medicinal plants have high flavonoids and flavanols that have strong scavenging capacity against free radicals.…”