Free Radical Scavenging Activity of Synthetic and Naturally Occurring Polyhydroxy-, Aminohydroxynaphthazarins and Related Compounds

Polonik, N. S.; Sabutskii, Yuri E.; Полоник, С. Г.

doi:10.1177/1934578x1801301021

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…72 No physiological action is known for compounds 4, 5, and 6, whereas the only effect reported for 7 and its derivative 8 is the scavenging of free radicals. 73 Therapeutic Uses of the Discovered sGC Natural Inhibitors. As described in the introduction, sGC is involved particularly in cancer, apoptosis, and angiogenesis.…”

Section: ■ Discussionmentioning

confidence: 99%

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Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds

et al. 2020

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Soluble guanylate cyclase (sGC) is the human receptor of nitric oxide (NO) in numerous kinds of cells and produces the second messenger 3′,5′-cyclic guanosine monophosphate (cGMP) upon NO binding to its heme. sGC is involved in many cell signaling pathways both under healthy conditions and under pathological conditions, such as angiogenesis associated with tumor growth. Addressing the selective inhibition of the NO/cGMP pathway is a strategy worthwhile to be investigated for slowing down tumoral angiogenesis or for curing vasoplegia. However, sGC inhibitors are lacking investigation. We have explored a chemical library of various natural compounds and have discovered inhibitors of sGC. The selected compounds were evaluated for their inhibition of purified sGC in vitro and sGC in endothelial cells. Six natural compounds, from various organisms, have IC50 in the range 0.2–1.5 μM for inhibiting the NO-activated synthesis of cGMP by sGC, and selected compounds exhibit a quantified antiangiogenic activity using an endothelial cell line. These sGC inhibitors can be used directly as tools to investigate angiogenesis and cell signaling or as templates for drug design.

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Section: ■ Discussionmentioning

confidence: 99%

“…It was also shown to inhibit competitively two bacterial β-hydroxyacyl–acyl carrier protein dehydratases (IC 50 = 13–28 μM) . No physiological action is known for compounds 4 , 5 , and 6 , whereas the only effect reported for 7 and its derivative 8 is the scavenging of free radicals …”

Section: Discussionmentioning

confidence: 99%

Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds

et al. 2020

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“…4 It is well known that an antiradical activity is the most common property of naphthazarin pigments and their derivatives. 1,[5][6][7] In continuation of our study of structure-antiradical activity relationships of naphthazarin pigments and their derivatives, we also evaluated ABTS •+ scavenging activity of naphthazarin-carbohydrate conjugates to clarify the effect of a sugar fragment on the activity. The antiradical activity of naphthazarin-carbohydrate nonglycoside conjugates is studied for the first time.…”

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confidence: 99%

Antiradical Activity of Naphthazarin-Carbohydrate Nonglycoside Conjugates

Utkina

Pokhilo

Atopkina

2019

Natural Product Communications

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The ABTS •+ scavenging activity of known (4, 6-8) and new (5,(9)(10)(11)(12) naphthazarin-carbohydrate nonglycoside conjugates, and methoxynaphthazarins 1-3 was evaluated. The study of structure-activity relationships showed that the presence of carbohydrate fragments in the structure of naphthazarin-carbohydrate conjugates increased their antiradical activity compared with starting methoxynaphthazarins. Antiradical activity depends on the structure of carbohydrate fragments, their number, and position. Depending on the carbohydrate fragment the activity increased in the following order: methyl-α-d-glucopyranoside < d-glucofuranose < 1,2-O-isopropylidene-α-d-glucofuranose. The 2 sugar residues and their 3,7-position enhanced the activity of the conjugates.

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Capacidad antioxidante y mecanismo de acción de pigmentos en organismos marinos

Ezquerra‐Brauer¹,

Chan‐Higuera²

2021

CienciaUAT

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Los organismos marinos poseen maravillosos colores que los hacen muy atractivos. Las características únicas de los compuestos sintetizados por especies de origen marino van más allá de su apariencia. Los pigmentos responsables de esos colores son capaces también de generar diversas actividades biológicas, como la capacidad antioxidante, la cual puede ocurrir a través de diversos mecanismos. Esto ha propiciado un aumento de su investigación, debido a su amplia aplicación en la biotecnología, farmacéutica, cosmética y alimentación de organismos vivos, expandiendo los estudios tanto in vitro como en ensayos in vivo. El objetivo de este trabajo fue compilar y describir diversos estudios recientes, enfocados en demostrar y elucidar los mecanismos de acción de los diferentes compuestos bioquímicos con actividad antioxidante, provenientes de algunos organismos marinos. Para ello, se utilizaron las bases de datos Scopus®, Web of Science™ y Microsoft Academic. Los pigmentos provenientes de organismos marinos representan una alternativa promisoria frente a los antioxidantes y aditivos sintéticos utilizados en la actualidad. El establecimiento y comprensión de los mecanismos de acción de los componentes pigmentados bioactivos, aislados de los organismos marinos, permitirá determinar con mayor precisión su posible aplicación en la industria.

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Free Radical Scavenging Activity of Synthetic and Naturally Occurring Polyhydroxy-, Aminohydroxynaphthazarins and Related Compounds

Cited by 3 publications

References 12 publications

Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds

Soluble Guanylate Cyclase Inhibitors Discovered among Natural Compounds

Antiradical Activity of Naphthazarin-Carbohydrate Nonglycoside Conjugates

Capacidad antioxidante y mecanismo de acción de pigmentos en organismos marinos

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