Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury

Ishii, Hideaki; Petrenko, Andrey B.; Sasaki, Mika; Satoh, Yukio; Kamiya, Yoshinori; Tobita, Toshiyuki; Furutani, Kenta; Matsuhashi, Mari; Kohno, Tatsuro; Baba, Hiroshi

doi:10.1016/j.brainres.2017.12.035

Cited by 25 publications

(15 citation statements)

References 49 publications

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“…used to obtain scavenging free radicals in rodents [46][47][48]. Therefore, we investigated the two doses (10 and 100 µg/kg/min) effects of edaravone in the present study.…”

Section: Discussionmentioning

confidence: 99%

Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Michino

Tanabe

Takenaka

et al. 2021

Korean J Anesthesiol

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“…used to obtain scavenging free radicals in rodents [46][47][48]. Therefore, we investigated the two doses (10 and 100 µg/kg/min) effects of edaravone in the present study.…”

Section: Discussionmentioning

confidence: 99%

Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Michino

Tanabe

Takenaka

et al. 2021

Korean J Anesthesiol

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“…Edaravone is a free radical scavenger with good neuroprotective effects [5,6], which can decrease damage in the vascular endothelial cells and relieve neuronal injury due to ischemic meningeal diseases [7]. In addition, such drug can prevent damage from oxidation of the cell membrane and inhibit brain edema and cerebral infarction due to cerebral hemorrhage [8].…”

Section: Introductionmentioning

confidence: 99%

Effects of Edaravone on Neurological Function and Tumor Necrosis Factor Alpha and Interleukin 8 Levels in Patients with Cerebral Infarction

Sun

2020

Eur Neurol

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Objective: The present study aimed to explore the effects of edaravone on neurological function, tumor necrosis factor α (TNF-α), and interleukin (IL)-8 levels in patients with cerebral infarction. Methods: A total of 96 patients with cerebral infarction who were admitted to the department of neurology in our hospital were enrolled in the present study, and they were randomly assigned to Group A (n = 48) and Group B (n = 48). Group A was treated with conventional therapy plus edaravone for 2 weeks and Group B with conventional therapy alone for 2 weeks. Enzyme-linked immunosorbent assay was used to determine serum TNF-α and IL-8 levels before and after treatment, and Pearson correlation analysis was conducted to analyze the correlation between serum TNF-α and IL-8 levels as well as National Institutes of Health Stroke Scale (NIHSS) score. Results: After treatment, Group A had a lower NIHSS score and serum TNF-α and IL-8 levels as well as higher activities of daily living score than Group B (all p < 0.05). In addition, after treatment, no significant differences were observed between the 2 groups in terms of the presence of adverse reactions (p > 0.05). Pearson correlation analysis revealed a significant positive correlation between serum TNF-α and IL-8 levels as well as NIHSS score (r = -0.567 and r = -0.556, both p < 0.05). Conclusion: Edaravone can improve the neurological function of patients without causing evident adverse reactions, thereby improving quality of life, which may be correlated to decreased serum TNF-α and IL-8 levels.

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“…Secondary injury results from a complex cascade of molecular events, including neuronal loss [5,6], excessive in ammatory response [7], demyelination [8], and oxidative stress [9]. Mounting evidence suggests that, among these, neuronal loss [10] and excessive in ammatory response [7] are especially grievous, by causing persistent damage and progressive degeneration of the spinal cord.…”

Section: Introductionmentioning

confidence: 99%

Dopamine Reduced Pyroptosis and Improved Functional Recovery After Spinal Cord Injury 

Zhu

Ding

et al. 2020

Preprint

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Background: Neuronal loss, demyelination, and an excessive inflammatory response accompany the pathogenesis of spinal cord injury (SCI). The inflammatory response is promoted by inflammasomes in variety diseases. Dopamine is a neurotransmitter that also functions as a regulator in NLRP3 (nucleotide-binding oligomerization domain-like receptor 3) inflammasome-dependent neuroinflammation. However, the effects and molecular mechanisms underlying the role of dopamine in SCI are little known. Methods:Functional recovery was assessed using Basso Mouse Scale (BMS) and BMS subscore. Histopathologic damage was evaluated by H&E staining. Demyelination was evaluated using immunofluorescence staining of myelin basic protein. Neuronal loss was evaluated by immunochemistry staining of NeuN. Pyroptosis was assessed by flow cytometry, western blot, and cell viability and cytotoxicity assays.Results: This study using mice showed that dopamine was significantly associated with enhanced locomotor recovery after SCI; with a reduction in NLRP3 inflammasome activation, pyroptosis, neuron and myelin loss, and histological changes. In vitro data suggested an association between dopamine and suppressed NLRP3 inflammasome activation and neuronal pyroptosis, and greater survival of neurons. Conclusion: Thus, dopamine may be a novel and effective approach for improving recovery after SCI.

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Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury

Cited by 25 publications

References 49 publications

Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Effects of Edaravone on Neurological Function and Tumor Necrosis Factor Alpha and Interleukin 8 Levels in Patients with Cerebral Infarction

Dopamine Reduced Pyroptosis and Improved Functional Recovery After Spinal Cord Injury

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Free radical scavenger edaravone produces robust neuroprotection in a rat model of spinal cord injury

Cited by 25 publications

References 49 publications

Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Edaravone attenuates sustained pial arteriolar vasoconstriction independently of endothelial function after unclamping of the abdominal aorta in rabbits

Effects of Edaravone on Neurological Function and Tumor Necrosis Factor Alpha and Interleukin 8 Levels in Patients with Cerebral Infarction

Dopamine Reduced Pyroptosis and Improved Functional Recovery After Spinal Cord Injury&nbsp;

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Dopamine Reduced Pyroptosis and Improved Functional Recovery After Spinal Cord Injury