Free‐Radical Multicomponent Processes

Trifluoromethyl radical triggered radical cyclization of N-benzoyl ynamides leading to isoindolinones

“…The crude was purified to afford N-methyl-N-(2triisopropylsilylethynyl)benzamide 2d as a yellow oil (682 mg, 42 % yield). Spectral data are in accordance with those reported in the literature 4 .…”

“…SADABS was used for scaling and absorption corrections. The structures were solved with SHELXS-2014 1 for 4aZ or SHELXT-2014 2 for 4aE, and refined by full-matrix least-squares methods with SHELXL-2014 3 using the Olex2 software package 4 . All non-hydrogen atoms were refined anisotropically.…”

“…Inter-and intramolecular radical addition -cyclization tandems constitute a powerful method to assemble various scaffolds depending on the used partners [1][2][3][4][5][6][7][8][9]. For instance, this approach has been applied by using a trifluoromethyl radical as a trigger [10][11][12] to synthesize valuable fluorine containing substrates [13][14][15][16].…”

A visible-light mediated three-component radical process using dithiocarbamate anion catalysis

“…Multicomponent reactions (MCRs) are important in synthetic chemistry because they allow the rapid construction of complex molecules from simple substrates and in a single step 1. While chemists have predominantly developed methods based on polar pathways, radical reactivity provides a powerful alternative 2,3. However, methods to initiate radical MCRs have traditionally required unstable initiators or stoichiometric oxidants or reductants (Fig.…”

An Intermolecular Azidoheteroarylation of Simple Alkenes via Free-Radical Multicomponent Cascade Reactions

“…Multicomponent cascade processes feature step-economy and simplicity of operation, which represent the most efficient and attractive synthetic organic transformations. Advances in ionic and/or organometallic multicomponent reactions have been made in recent decades . In contrast, free-radical mediated efficient multicomponent reactions remain to be explored .…”