Free-Radical-Mediated DNA Binding

Abstract

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Intercalation and Induction of Strand Breaks by Adriamycin and Daunomycin: A Study with Human Genomic DNA

“…Although antitumor anthracycline drugs could function by noncovalent binding to DNA (Waring, 1981), it is now widely accepted that radical-mediated DNA strand breaks are important in accounting for cell death (O'Brien, 1985). The auto-oxidizable semiquinone radicals may be formed by microsomal or nuclear cytochrome P-450 reductase (Berlin and Haseltine, 1981).…”

Organometallic Compounds in Biomedical Applications

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