Free Radical Drug Enhancement

Gooley, C.M.; Keyzer, H.; Setchell, F.

doi:10.1038/223080a0

Cited by 38 publications

(14 citation statements)

References 4 publications

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“…CNS agents in general (25) and phenothiazines, such as chlorpromazine, in particular (25,26) can reduce body temperature (hypothermia) in mice. CNS agents in general (25) and phenothiazines, such as chlorpromazine, in particular (25,26) can reduce body temperature (hypothermia) in mice.…”

Section: Discussionmentioning

confidence: 99%

Potential CNS Antitumor Agents—Phenothiazines II: Fluphenazine Analogs

Hirata

Peng

Driscoll

1978

Journal of Pharmaceutical Sciences

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Section: Discussionmentioning

confidence: 99%

Potential CNS Antitumor Agents—Phenothiazines II: Fluphenazine Analogs

Hirata

Peng

Driscoll

1978

Journal of Pharmaceutical Sciences

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“…The experimental results indicate that only one crystallographically independent dication is present in the single crystal, having a C-S-C angle of 102.6(4)" and S-C bond lengths of 1.709 (11) and 1.710 (7) A, midway between the values for a C-S single (1.8 1 A) and double bond (1.6 1 A). As in the case of phenothiazine cation radical (PTAZ'),'' this suggests that the n-delocalization is spread over the central ring.…”

Section: Discussionmentioning

confidence: 83%

“…For unsubstituted phenothiazine radical (PTAZ+) differences in the type of counterions modify the packing and some molecular angles as C,-C, or C( 12)-N( l)-C(5). For CPZ+ and HALMZ' + radicals, as the perchlorate salt, some differences are observed for the c 6 -c 6 and C(7)-S-C(7) angles and S-C(4) and S-C (7) bond lengths; the angles increasing and the bonds becoming shorter on going from CPZ+ to HALMZ+. These results agree well with greater participation of the sulphur atom in the molecular conjugation in the case of HALMZ2+ and can explain the differences between the g values of HALMZ2+ and CPZ' radicals observed in the solid state by e.s.r.…”

Section: -Xy2-zmentioning

confidence: 95%

Crystal and molecular structure of the alimemazine cation radical

Apreda¹,

Cano²,

Foces‐Foces³

et al. 1987

J. Chem. Soc., Perkin Trans. 2

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The crystal structure of the alimemazine (trimeprazine) cation radical, a phenothiazine drug molecule, has been determined from three-dimensional X-ray diffraction data and refined by least-squares methods. Cell constants were a 10.674 9(4), b 12.741 9(5), c 9.509 9(4) A, a 110.863(3), p 103.433(3), y 66.671 (4)", Z = 2. The molecule is planar, the angle between the best planes for the two benzene rings being 1.9(3)", The C-S-C angle is 102.6(4)" and S-C bonds are 1.709(11) and 1.71 O(7) A in length. The side-chain is protonated at the nitrogen atom and asymmetrically placed in relation to the tricyclic system.The pharmacological properties of phenothiazine drugs has stimulated research on their structural features in the solid state by X-ray in an attempt to provide information on the structure-activity relationships in this class of However, in spite of the biological activity of the cation radical and of the interesting solidstate properties of their ion radical salts9*10 the number of X-ray diffraction studies on this type of species is few. 11-'In previous works we have studied the alimemazine cationphenothiazine], a phenothiazine drug with a side-chain branched due to the presence of a methyl group at the level of the second carbon,14*15 by means of e.s.r. The results showed conformational changes in solution in relation to unbranched radicals. To determine how this difference in the side-chain affects the structural characteristics of ALMZ' in the solid state, we have carried out an X-ray diffraction study of this radical. The results are compared with those previously reported for other phenothiazine cation radicals, mainly chlorpromazine (CPZ'), because the single crystals contained the same type of counterion.

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“…It is sublimating, has a faint odor, is irritating to the skin, can cause rashes, can also be absorbed through the skin and cause visceral disorders. Phenothiazine as an intermediate in the manufacture of methylene blue dyes, which can also be used to make a class of important antihistamines and antihistamines such as chlorpromazine, perphenazine, is opropyrazine and dioxpromazine hydrochloride [1][2][3][4][5]. In addition, phenothiazine can also be used as inhibitors of vinyl acetate, raw materials for rubber antioxidants, synthetic dyes, drugs, fruit tree insecticides and livestock repellents.…”

Section: Phenothiazine Compoundsmentioning

confidence: 99%

Research Progress of Phenothiazine Compounds of Dioxopromethazine Hydrochloride

Zhao¹,

Chuanbo²,

Gao³

2018

Topics in Chemical &Amp; Material Engineering

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With the development of science and technology and the progress of society, people are paying more attention to the environment and energy while paying attention to production and benefits. Phenothiazine compounds are very important heterocyclic compounds. They have been widely used in medicine, electroluminescent materials, solar cells, polymerization inhibitors, antioxidants, antioxidants and other fields in recent years. This article briefly introduces the application and technological progress of phenothiazine compounds. Dioxopromazine hydrochloride is a type of phenothiazine compounds, which have high application and research value in the aspects of relieving cough, relieving asthma, eliminating phlegm ,antihistamine and so on. In this paper, we will summarize the oxidation processes commonly used in the production of dioxaprozin hydrochloride to make it more green and efficient,and provide a reference for the development of dioxopromazine hydrochloride, and look forward to the future production process and research direction.

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Free Radical Drug Enhancement

Cited by 38 publications

References 4 publications

Potential CNS Antitumor Agents—Phenothiazines II: Fluphenazine Analogs

Potential CNS Antitumor Agents—Phenothiazines II: Fluphenazine Analogs

Crystal and molecular structure of the alimemazine cation radical

Research Progress of Phenothiazine Compounds of Dioxopromethazine Hydrochloride

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