Free Radical Content of Drugs Used in Ophthalmology

Sakarya, Yaşar; Kurku, Hüseyin; Sakarya, Rabia; Özçimen, Muammer; Kara, Selçuk

doi:10.29333/ejgm/82470

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…12,13 Also, many drugs like vancomycin and cefuroxime have shown numbers of free radicals in preservative as well as non-preservative form that are toxic to corneal endothelium. 14,15…”

Section: Discussionmentioning

confidence: 99%

“…12,13 Also, many drugs like vancomycin and cefuroxime have shown numbers of free radicals in preservative as well as non-preservative form that are toxic to corneal endothelium. 14,15 Moxifloxacin is US-FDA approved drug for topical use, self-preserved and easily available commercial ophthalmic solution. It involves no special preparation for intracameral delivery.…”

Section: Discussionmentioning

confidence: 99%

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Impact on corneal morphology after cataract surgery with intracameral moxifloxacin in neglected hard cataracts

Gupta

Vichare

Kumar

et al. 2022

European Journal of Ophthalmology

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Aim To evaluate corneal morphology after use of 0.5% intracameral moxifloxacin (ICM) in cataract surgery in patients who presented late with hard cataracts. Methods Cross-sectional study conducted from June-2021 to December-2021 at a tertiary eye-care center. 90 patients over 60 years with high-risk characteristics for Covid-19, who presented late with higher grades of nuclear-sclerosis (NS), were included. They underwent phacoemulsification and 0.5%moxifloxacin (0.1 ml) was injected intracamerally at the end of surgery. Best-corrected visual acuity (BCVA), intraocular pressures (IOP), endothelial cell density (ECD), coefficient of variation in cell-area (CoV), hexagonality (Hex) and central corneal thickness (CCT) were measured preoperatively and postoperatively on day1, day7 and day30. Statistical analysis was done by Anova test. p-value<0.05 was considered significant. Results Mean age of presentation was 65.26±8.3 years. Mean preoperative BCVA (1/60-to-6/60), IOP (16.7±2.3 mm of Hg), CCT (523.93±39.6µ), ECD (2547±302.08cells/mm2), Hex (47.04±5.7%) and CoV (37.57±3.9) changed to BCVA (6/9-to-6/6), IOP (17.5±2.1 mm of Hg), CCT (538.42±36.9µ), ECD (2388.40±339.25cells/mm2), Hex (44.44±5.6%) and CoV (39.09±4.5) at day30 postoperative. Average rate of change at day30 was increase in CCT (2.89%), ECD loss (6.4%), decrease in Hex (4.9%) and increase in CoV (4.6%), though clinically insignificant. No case of endophthalmitis or toxic-anterior segment syndrome seen. Conclusion 0.5% moxifloxacin (0.1 ml) is safe as intracameral antibiotic to prevent postoperative infection in high-risk patients. The reported changes in the corneal parameters were within the range of any routine surgeries of hard senile cataracts. No specific effect could be attributed to ICM.

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“…12,13 Also, many drugs like vancomycin and cefuroxime have shown numbers of free radicals in preservative as well as non-preservative form that are toxic to corneal endothelium. 14,15…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact on corneal morphology after cataract surgery with intracameral moxifloxacin in neglected hard cataracts

Gupta

Vichare

Kumar

et al. 2022

European Journal of Ophthalmology

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“…Для лечения развитых кератомикозов применяют интракамеральные инъекции противогрибковых средств в виде растворов высоких разведений [45][46][47][48][49][50][51].…”

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Ocular toxicity of intracamerally injected antibacterial and antifungal drugs (experimental and morphological study)

2015

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Application of EPR spectroscopy to examine free radicals evolution during storage of the thermally sterilized Ungentum ophthalmicum

Ramos

Pilawa

2016

Pharmaceutical Development and Technology

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Free radicals formed during thermal sterilization of the Ungentum ophthalmicum were examined by an X-band EPR spectroscopy. The influence of storage time (15 min; 1, 2 and 3 days after heating) on free radical properties and concentrations in this sample was determined. Thermal sterilization was done according to the pharmaceutical norms. The first-derivative EPR spectra with g-values about 2 were measured with magnetic modulation of 100 kHz in the range of microwave power 2.2-70 mW. The changes of amplitudes (A) and linewidths (ΔB) with microwave powers were evaluated. Free radicals in concentration ∼10 spin/g were formed during heating of the tested Ungentum. Free radical concentration decreased with increase in storage time, and reached values ∼10 spin/g after 3 days from sterilization. The tested U. ophthalmicum should not be sterilized at a temperature of 160 °C because of the free radicals formation, or it should be used 3 days after heating, when free radicals were considerably quenched. Free radical properties remain unchanged during storage of the Ungentum. The EPR lines of the U. ophthalmicum were homogeneously broadened and their linewidths (ΔB) increased with increase in microwave power. EPR spectroscopy is useful to examine free radicals to optimize sterilization process and storage conditions of ophthalmologic samples.

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Free Radical Content of Drugs Used in Ophthalmology

Abstract: ABSTRACT

Cited by 3 publications

References 19 publications

Impact on corneal morphology after cataract surgery with intracameral moxifloxacin in neglected hard cataracts

Impact on corneal morphology after cataract surgery with intracameral moxifloxacin in neglected hard cataracts

Ocular toxicity of intracamerally injected antibacterial and antifungal drugs (experimental and morphological study)

Application of EPR spectroscopy to examine free radicals evolution during storage of the thermally sterilized Ungentum ophthalmicum

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