Free radical biology in cellular inflammation related to rheumatoid arthritis

Bala, Asis; Haldar, P. K.

doi:10.13172/2052-9554-1-2-1013

Cited by 11 publications

(11 citation statements)

References 40 publications

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“……… [9] The current study shows that NOS is more active in RA patients compare to control and this is additional cause to increase the level of ONOO where there are significant positive correlation between NOS activity and ONOO level where, the results of the present study show that there is increase level of NO in RA patient compare to the control and this is due to increasing activity of NOS. The increase activity of NOS in RA patient might be due to the fact that NO is involved in immune, inflammatory and autoimmune basis of arthritis [24] where NO has a role in cardinal signs of inflammation [25].…”

supporting

confidence: 57%

“…The presence of citrullinated proteins leads to abnormal an immune response that causes the generation of anti cyclic citrullinated peptide (anti-CCP) antibodies to develop into RA disease [7]. ROS may impair the activity of enzymatic antioxidant superoxide dismutase (SOD) [8] thus, lead to availability of superoxide union (O2•-) that reacts with nitric oxide (NO) (which synthesized from the deimination L-arginine by nitric oxide synthase (NOS)) and thus produce the highly reactive peroxy nitrite (ONOO) [9]. The conditions that help to produce high level of ONOO are the excess production of NO [2] and limited activity of SOD because this help to availability of (O2•-) which react with NO to give ONOO.…”

Section: Introductionmentioning

confidence: 99%

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Disorder Activity of Some Enzymes Plays an Important Role in Pathological Mechanism of Rheumatoid Arthritis Disease

Journal¹

2015

Baghdad Sci.J

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The aim of this research to show the role of some enzymes in pathological mechanism of rheumatoid arthritis (RA) disease. Sixty patients with RA and matched number of apparently healthy volunteers were included in the study. Spectrophotometric methods were used to determine Peroxy nitrite (ONOO), Nitric oxide (NO), Nitric oxide synthase activity (NOS) cycloxygenase-2 activity (COX-2), glutathione peroxidase (GPX) activity and superoxide dismutase (SOD) activity in serum of both groups. Colorimetric assay kits were used to determine Iron. Rheumatoid factor (RF) was determined using Imuno-Latex kit. ONOO, NO levels, and NOS activity were significantly higher in the patients compared to the control group. Conversely, Iron level, SOD activity and GPX activity were significantly lower in the patients compared to the control. In patients group, RF has significant positive correlation with COX-2, NOS activity and NO level while; it has significant negative correlation with Iron level. ONOO level has significant positive correlation with NO level, NOS activity and COX-2 activity while has significant negative correlation with Iron and SOD activity. NOS activity and NO level have significant positive correlation with COX-2 activity while, they have negative correlation with Iron. Iron has significant negative correlation with COX-2 activity. In control group, COX-2 has significant positive correlation with NOS activity and ONOO level. GPX has significant positive correlation with SOD and Iron. In conclusion: disorder activity of COX-2, NOS, SOD and GPX enzymes play important role in the pathological mechanism of rheumatoid arthritis and they linked with a decreased level of serum iron

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supporting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Disorder Activity of Some Enzymes Plays an Important Role in Pathological Mechanism of Rheumatoid Arthritis Disease

Journal¹

2015

Baghdad Sci.J

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“…1. Upregulated levels of MMPs (Cree, 2011, Cunha-Vaz, 2009, Kaur et al, 2008, Luo et al, 2004, Bala and Haldar, 2013). and downregulated levels of TIMP1 and TIMP2 were detected in both cancer and cataract patients (Määttä et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…In eyes, oxidative stress is associated with the progression of various ocular pathologies such as macular degeneration, cataract, glaucoma, optic neuropathy and diabetic retinopathy (Choi et al, 2009). Oxidative stress enhances the production of pro-inflammatory cytokines by activating MAPK signaling pathways, stimulating transcription factors such as NF-KB and AP-1 which in turn activate the expression of different pro-inflammatory cytokine genes such as TNF-α, IL-1, IL-6 and IL-10 (Luo et al, 2004, Bala and Haldar, 2013). Higher level of TNF-α is also involved in the up-regulation of matrix metallo-proteinases (MMPs) by activating nuclear transcription factors, AP-1 and NF-kB in keratinocytes.…”

Section: Introductionmentioning

confidence: 99%

Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders

Rasool

Malik

Ashraf

et al. 2018

Saudi Journal of Biological Sciences

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BackgroundCancer patients when treated with different chemotherapeutic drugs often develop mild to severe sight threatening diseases during or after chemotherapy. The mechanism involved in the pathogenesis of ocular toxicities is poorly understood. Oxidative stress, inflammation and MMPs (angiogenic factor) are involved in the progression of chemotherapy related ocular disorders.Materials and methodsThe concentration of oxidative stress markers such as MDA, NO and levels of different antioxidant molecules such as SOD, CAT, GSH, GPx, GPr, VIT A, VIT E and VIT C present in the serum of chemotherapy treated patients (n = 50) and in normal persons (n = 20) were estimated by the direct spectrophotometric method while the concentration of TNF-α and MMP-9 activity were determined using human TNF-α and MMP-9 ELISA kits.ResultsThe concentration of SOD and CAT (0.356 ± 0.05 μg/dl and 1.26 ± 0.01 μmol/mol of protein) was significantly lower as compared to that (1.09 ± 0.03 μg/dl and 3.99 ± 0.04 μmol/mol of protein) in controls. The levels of GPx (0.06 ± 0.01 mmol/dl) in the cancer patients were much lower than those in the controls (0.78 ± 0.06 mmol/dl). Lower level of GSH (0.96 ± 0.003 μg/dl) in serum of the diseased group was observed as compared to healthy group (7.26 ± 1.40 μg/dl). The level of Vit A, Vit C and Vit E was lower in systemic circulation of cancer patients (109.99 ± 6.35 μg/ml, 1.26 ± 0.36 μg/ml and 1.29 ± 0.191 μg/ml) as compared to control subjects (166.35 ± 14.26 μg/ml, 3.25 ± 0.099 μg/ml and 6.354 ± 2.26 μg/ml) respectively. The concentration of nitric oxide was significantly higher in the cancer patients (45.26 ± 6.35 ng/ml) than that in the normal subjects (16.35 ± 3.26 ng/ml). The higher concentration of MDA (8.65 ± 3.26 nmol/ml) was observed in the patients than normal ones (1.254 ± 0.065 nmol/ml). The quantity of TNF-α was significantly higher in chemotherapy treated patients (32.68 ± 4.33 pg/ml) as compared to the control group (20.979 ± 1.98 pg/ml). Significantly higher concentration of MMP-9 (40.26 ± 3.26 ng/ml) was observed in the cancer patients than the controls (7.256 ± 1.95 ng/ml).ConclusionLower levels of antioxidant enzymes and non-enzymatic small molecules and higher levels of oxidative stress and inflammatory clinical parameters such as NO, MDA, TNF-α and MMP-9 may be involved in the pathogenesis of systemic chemotherapy related ocular complications such as cataract, glaucoma, blepharitis, retinitis pigmentosa, macular degeneration, pterygium and retinal degeneration.

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“…Chronic inflammation lead to pathological conditions. 6 The inflammatory process that occurs as a initiators of pathological conditions due to excessive free radical, will be reviewed in this article…”

Section: Introductionmentioning

confidence: 99%

Free Radical, Oxidative Stress and Its Roles on Inflammatory Response

Tania¹

2018

J. Berk. Ked

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Chronic inflammation contributes to the occurrence of various metabolic diseases and even cancer. Chronic inflammation results from excessive response of free radicals. Free radicals are triggered by various agents and oxidation processes in the body as Reactive Oxygen Stress (ROS). The high level of free radicals (oxidants), without adequate intake of antioxidants will lead to oxidative stress conditions. Oxidative stress triggers persistent of inflammation. The formation of ROS is difficult to avoid because it can be generated from cellular metabolic processes. Therefore, we should intake adequate of antioxidants and avoid the various agents induces ROS in everyday life. Keywords : ROS, Stress Oxidative, Inflammation

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Free radical biology in cellular inflammation related to rheumatoid arthritis

Cited by 11 publications

References 40 publications

Disorder Activity of Some Enzymes Plays an Important Role in Pathological Mechanism of Rheumatoid Arthritis Disease

Disorder Activity of Some Enzymes Plays an Important Role in Pathological Mechanism of Rheumatoid Arthritis Disease

Role of diagnostic factors associated with antioxidative status and expression of matrix metalloproteinases (MMPs) in patients with cancer therapy induced ocular disorders

Free Radical, Oxidative Stress and Its Roles on Inflammatory Response

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