Free Malignant Cells in Relation to Recurrence of Carcinoma of the Colon

McGrew, Elizabeth A.

doi:10.1001/jama.1954.02940490015004

Cited by 112 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 1951, McGrew et al speculated that these cells caused suture-line recurrence. 11 Exfoliated tumor cells (more than 90% viable) were also demonstrated in 52 of 74 (70%) colorectal lavage specimens. 12 The occurrence of tumor implantation in ischemic, thermic, and mechanical lesions of the colonic mucosa has been shown experimentally in rats.…”

Section: Discussionmentioning

confidence: 94%

The rapid growth of intraluminal tumor metastases at the intestinal wall sites damaged by obstructive colitis due to sigmoid colon cancer: Report of a case

et al. 2008

View full text Add to dashboard Cite

A 53-year-old woman who was traveling in Australia was admitted to a local hospital with pyrexia and diarrhea. Megacolon was diagnosed from an X-ray and an emergency operation was performed. However, the cause of megacolon was not clear, and the attempted operation ended in a simple laparotomy. Sigmoid cancer was found 3 weeks after the first operation and a colostomy was performed at the ascending colon. After the second operation, she returned to Japan and was thereafter admitted to our hospital. Total colonoscopy before the third surgery (sigmoidectomy) revealed erosive mucosa but no tumor. The damaged mucosa in the proximal colon (compatible with a diagnosis of obstructive colitis) was found during a sigmoidectomy. Watery diarrhea and melena persisted after the third operation. Colonoscopy showed disseminated tumor nodules at the proximal colon of the anastomosis at 37 days after the third surgery. Finally, a subtotal colectomy and jejunal pouch reconstruction were carried out. The exfoliated malignant cells from the sigmoid colon appeared to form micrometastases in the mucosal sites damaged by obstructive colitis. In conclusion, in a case of obstructive colitis due to cancer, we must consider the possibility that the tumor may spread to damaged mucosal sites and grow intraluminally.

show abstract

Section: Discussionmentioning

confidence: 94%

The rapid growth of intraluminal tumor metastases at the intestinal wall sites damaged by obstructive colitis due to sigmoid colon cancer: Report of a case

et al. 2008

View full text Add to dashboard Cite

show abstract

“…In 1954, McGrew et al [6] isolated exfoliated cancer cells from malignant colorectal tumors without determining their viability, and Umpleby et al [7] reported that a cytological examination revealed the viability of exfoliated cells that could be detected intraluminally as far as 35 cm proximal to the resection margin in colorectal cancer specimens.…”

Section: Discussionmentioning

confidence: 99%

Suture-line recurrence at a jejunojejunal anastomosis after gastrectomy for gastric cancer

et al. 2008

View full text Add to dashboard Cite

“…2,3 Millions of exfoliated malignant cells have been found in the lumen of colectomy specimens, 4 often at considerable distances from the tumor. 5 These tumor cells have been found to implant in traumatic anal tears 6 and mucosal biopsy sites 7 and have been implicated as a key factor in anastomotic recurrence. 8 The further observation that cancer cells tend to adhere to suture material 9 and may be identified on intraluminal surgical stapling devices 10 has highlighted the potential role of exfoliated tumor cell implantation at surgical anastomoses.…”

Section: Discussionmentioning

confidence: 99%