Free Functioning Muscle Transfer for Lower Extremity Posttraumatic Composite Structure and Functional Defect

Lin, Chih‐Hung; Lin, Yu‐Te; Yeh, Jiun‐Ting; Chen, Chien-Tzung

doi:10.1097/01.prs.0000260595.85557.41

Cited by 120 publications

(78 citation statements)

References 16 publications

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“…Acceptable outcomes were achieved in 10 of 15 patients. 13 We have found functional free muscle flaps to be a valuable tool in individuals who have limited options for traditional tendon transfers.…”

Section: Compartment Syndromementioning

confidence: 99%

Muscle Flaps and their Role in Limb Salvage

Klebuc¹,

Menn

2013

Methodist DeBakey Cardiovascular Journal

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Muscle flaps have proved to be a valuable and versatile tool in the surgical treatment of the severely compromised lower extremity. Utilized as both local pedicle flaps and free tissue transfers, muscles have been successfully employed to cover complex wounds, manage osteomyelitis, salvage infected vascular grafts, treat recalcitrant venous stasis ulcers, preserve amputation levels, and restore motion following compartment syndrome. Free flap pedicles have also been used in a flow-through fashion to create a distal arterial bypass. This article explores the multipurpose role of muscle flaps in limb salvage surgery and their beneficial physiologic characteristics in hostile wound environments.

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Section: Compartment Syndromementioning

confidence: 99%

Muscle Flaps and their Role in Limb Salvage

Klebuc¹,

Menn

2013

Methodist DeBakey Cardiovascular Journal

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“…However, after direct injury the muscle mass is lost with minimal regeneration affecting long term recovery and function. Current clinical management options include functional free muscle transfer and the use of advanced bracing [3], which have limited efficiency on muscle recovery. Improvement of muscle regrowth is then of major concern in the treatment of those with severe and direct muscle injury.…”

Section: Introductionmentioning

confidence: 99%

Porcine urinary bladder extracellular matrix activates skeletal myogenesis in mouse muscle cryoinjury

Song¹,

Hornsby²,

Stanley³

et al. 2014

J Regen Med Tissue Eng

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Background: Accelerated muscle regeneration is highly desirable after direct injury in trauma patients. Though the advantage of extracellular matrix extracted from porcine urine bladder (UBM) on tissue regeneration is feasible, the mechanisms by which skeletal myogenesis is improved are not clear. The current study aim was to determine whether UBM affects skeletal satellite cells during muscle repair after cryoinjury. Methods: RAG2-/-, γc -/-mice underwent bilateral gluteus muscle cryoinjury under general anesthesia. 200µg UBM suspended in 20 µl of Matrigel solution was implanted on one side of the wound intramuscularly, and 20µl of vehicle was applied on the contralateral side as a sham treatment. Five animals without any operation served as baseline. Mice were sacrificed from days 1 to 28 after injury for muscle tissue collection. Tissue morphology was estimated via H&E staining. Satellite cell proliferation was examined by immunofluorescence staining and western blot. Myogenesis markers were assessed by qPCR. Results: H&E staining results showed that muscle regeneration area increased in both sham and UBM treated muscles following injury. The number of regenerating myotubes was significantly higher in UBM treated tissue at 28 days (p<0.05, vs. sham group). Both Pax7 + and Ki-67 + satellite cell number significantly increased in muscle with UBM treatment compared to sham treated muscles (p<0.05). Protein levels of proliferating cell nuclear antigen (PCNA) were greater in muscle with UBM treatment at day 14 and 28 (p<0.05). MyoD1 and myogenin mRNA levels were also significantly higher in UBM treated animal muscle at day 28 (p<0.05). Conclusion: UBM treatment increased skeletal satellite cell proliferation and myogenic differentiation at 28 days after local muscle injury.

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“…1 The primary treatment strategies involve muscle flap transposition or autologous tissue transfer. [4][5][6][7][8][9] Although each procedure type has demonstrated some success, both are limited by donor site morbidity and lack of available graft tissue. Thus, a demand exists for exogenous graft muscle tissue, prompting tissue engineering approaches to be increasingly investigated as potential strategies for VML treatment.…”

mentioning

confidence: 99%

Engineered Skeletal Muscle Units for Repair of Volumetric Muscle Loss in the Tibialis Anterior Muscle of a Rat

VanDusen

Syverud

Williams

et al. 2014

Tissue Engineering Part A

103

117

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Free Functioning Muscle Transfer for Lower Extremity Posttraumatic Composite Structure and Functional Defect

Abstract: Functioning muscle transfer can be performed posttraumatically in lower limbs with composite soft-tissue and motor-unit defects, resulting in acceptable functional results and reliable limb salvage.

Cited by 120 publications

References 16 publications

Muscle Flaps and their Role in Limb Salvage

Muscle Flaps and their Role in Limb Salvage

Porcine urinary bladder extracellular matrix activates skeletal myogenesis in mouse muscle cryoinjury

Engineered Skeletal Muscle Units for Repair of Volumetric Muscle Loss in the Tibialis Anterior Muscle of a Rat

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