Free Fatty Acids from Type 2 Diabetes Mellitus Serum Remodel Mesenchymal Stem Cell Lipids, Hindering Differentiation into Primordial Germ Cells

Norouzi, Zahra; Zarezadeh, Reza; Mehdizadeh, Amir; Niafar, Mitra; Germeyer, Ariane; Fayyazpour, Parisa; Fayezi, Shabnam

doi:10.1007/s12010-022-04204-z

Cited by 2 publications

(2 citation statements)

References 46 publications

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“…Numerous studies have identified a connection between disrupted lipid metabolism and fertility issues [320][321][322]. Pink adipocytes are a female-specific cell type created in the mammary glands during pregnancy, lactation, and postlactation periods from breast sWAT.…”

Section: Brown Adipose Tissue and Fertilitymentioning

confidence: 99%

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications

Ghesmati,

Rashid,

Fayezi

et al. 2023

Rev Endocr Metab Disord

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Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates energy as heat for thermoregulation. Beige adipose tissue is a hybrid form of adipose tissue that shares characteristics with WAT and BAT. Dysregulation of adipose tissue metabolism is linked to various disorders, including obesity, type 2 diabetes, cardiovascular diseases, cancer, and infertility. Both brown and beige adipocytes secrete multiple molecules, such as batokines, packaged in extracellular vesicles or as soluble signaling molecules that play autocrine, paracrine, and endocrine roles. A greater understanding of the adipocyte secretome is essential for identifying novel molecular targets in treating metabolic disorders. Additionally, microRNAs show crucial roles in regulating adipose tissue differentiation and function, highlighting their potential as biomarkers for metabolic disorders. The browning of WAT has emerged as a promising therapeutic approach in treating obesity and associated metabolic disorders. Many browning agents have been identified, and nanotechnology-based drug delivery systems have been developed to enhance their efficacy. This review scrutinizes the characteristics of and differences between white, brown, and beige adipose tissues, the molecular mechanisms involved in the development of the adipocytes, the significant roles of batokines, and regulatory microRNAs active in different adipose tissues. Finally, the potential of WAT browning in treating obesity and atherosclerosis, the relationship of BAT with cancer and fertility disorders, and the crosstalk between adipose tissue with circadian system and circadian disorders are also investigated.

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Section: Brown Adipose Tissue and Fertilitymentioning

confidence: 99%

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications

Ghesmati,

Rashid,

Fayezi

et al. 2023

Rev Endocr Metab Disord

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View full text Add to dashboard Cite

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“…In other words, nutrients can induce epigenetic changes, either through methylation of DNA or changes in some miRNAs expression. Carbohydrates or Carbs (CHO), proteins and fats are broken down during digestion into the composition monomers respectively monosaccharides, amino acids and fatty acids [ 10 , 64 ]. Few studies have been carried out on the role of carbs and lipids on bone health.…”

Section: Macronutrients Intake and Osteogenic Mirnas Expressionmentioning

confidence: 99%

MiRNAs Expression Modulates Osteogenesis in Response to Exercise and Nutrition

Proia,

Rossi,

Alioto

et al. 2023

Genes

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In recent years, many articles have been published describing the impact of physical activity and diet on bone health. This review has aimed to figure out the possible epigenetic mechanisms that influence bone metabolism. Many studies highlighted the effects of macro and micronutrients combined with exercise on the regulation of gene expression through miRs. The present review will describe how physical activity and nutrition can prevent abnormal epigenetic regulation that otherwise could lead to bone-metabolism-related diseases, the most significant of which is osteoporosis. Nowadays, it is known that this effect can be carried out not only by endogenously produced miRs, but also through those intakes through the diet. Indeed, they have also been found in the transcriptome of animals and plants, and it is possible to hypothesise an interaction between miRNAs produced by different kingdoms and epigenetic influences on human gene expression. In particular, the key to the activation pathways triggered by diet and physical activity appears to be the activation of Runt-related transcription factor 2 (RUNX2), the expression of which is regulated by several miRs. Among the main miRs involved are exercise-induced miR21 and 21-5p, and food-induced miR 221-3p and 222-3p.

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Free Fatty Acids from Type 2 Diabetes Mellitus Serum Remodel Mesenchymal Stem Cell Lipids, Hindering Differentiation into Primordial Germ Cells

Cited by 2 publications

References 46 publications

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications

An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications

MiRNAs Expression Modulates Osteogenesis in Response to Exercise and Nutrition

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