Free Fatty Acids Exert an Inhibitory Effect on Adrenocorticotropin and Cortisol Secretion in Humans

Lanfranco, Fabio; Giordano, Roberta; Pellegrino, Micaela; Gianotti, Laura; Ramunni, J.; Picu, Andreea; Baldi, Matteo; Ghigo, Ezio; Arvat, Emanuela

doi:10.1210/jc.2004-031132

Cited by 38 publications

(40 citation statements)

References 34 publications

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“…Studies in humans have suggested that infusion of Intralipid either had no effect or decreased cortisol concentrations. [10][11][12] However, many of these studies were performed under systems that maintained insulin and/or glucose concentrations at predetermined concentrations. Yet, Intralipid infusion in humans did not appear to influence whole-body cortisol metabolism, but did increase conversion of cortisone to cortisol in subcutaneous adipose tissue.…”

Section: Discussionmentioning

confidence: 99%

Exogenous administration of lipids to steers alters aspects of the innate immune response to endotoxin challenge

et al. 2014

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This study examined the effects of increasing energy availability from both dextrose and lipid treatments on the proinflammatory response to LPS in Holstein steers. Steers were randomly assigned to one of three groups: saline at 0.5 ml/ kg body weight (Control) or 50% dextrose [0.5 ml/kg body weight (Dextrose) to mimic calm cattle's response to LPS] administered immediately prior to LPS (0.5 mg/kg body weight at 0 h) or continuous lipid emulsion infusion from À1 to 6 h [Intralipid 20% (Baxter, Deerfield, IL USA); 0.5 ml/kg/hr (Lipid) to mimic temperamental cattle]. Concentrations of non-esterified fatty acids (NEFA) were greater in Lipid compared with Control and Dextrose steers. A greater decrease in the change in rectal temperature, relative to baseline, was observed in response to LPS in Dextrose in comparison to control and Lipid steers. Cortisol was greater in Lipid than Dextrose and Control steers from À0.5 to 0 h, yet decreased from 0.5 to 5.5 h relative to LPS challenge. Concentrations of IL-6 were decreased in Lipid steers compared with Dextrose and Control steers, and were decreased in Dextrose compared with Control steers post-LPS challenge. These data suggest that increasing circulating NEFA using an exogenous Lipid emulsion may modulate the pro-inflammatory response in steers.

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Section: Discussionmentioning

confidence: 99%

Exogenous administration of lipids to steers alters aspects of the innate immune response to endotoxin challenge

et al. 2014

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“…FFAs possess an electrophysiological effect on the central nervous system where they can be incorporated by central nervous system cells (44,45). Indeed, we have demonstrated that a lipid loadinduced increase in circulating FFA levels in healthy adult subjects exerts an inhibitory effect on spontaneous ACTH and cortisol secretion (11). Thus, we hypothesized some refractoriness of the enhanced HPA activity to lipid load in this pathological condition.…”

Section: Discussionmentioning

confidence: 91%

“…To increase the lipoprotein lipase activity, heparin was added to the suspension. We chose an Intralipid dose equivalent to that used in many studies focusing on the effects of FFAs on GH secretion in normal subjects and anorectic patients (1,3,4,38) and on HPA axis activity in normal subjects (11) and which showed a clear inhibitory effect on both somatotroph and corticotroph function. Blood samples were taken every 30 min from 0 to 180 min.…”

Section: Eightmentioning

confidence: 99%

“…However, a dual effect of lipids on adrenal activity has been reported (7 -10). We have recently demonstrated that a lipid load-induced increase in circulating FFA levels in healthy adult subjects exerts an inhibitory rather than a stimulatory effect on spontaneous adrenocorticotropin (ACTH) and cortisol secretion (11), suggesting that there may be a negative feedback link between FFAs and the HPA axis in humans. A relationship between the HPA axis and lipid metabolism is inferred, based on the lipolytic effect of glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

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Effects of free fatty acids on ACTH and cortisol secretion in anorexia nervosa

Lanfranco

Gianotti²,

Picu³

et al. 2006

eur j endocrinol

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Objective: Free fatty acids (FFAs) exert a stimulatory effect on the hypothalamic -pituitary -adrenal (HPA) axis in animals and inhibit spontaneous ACTH and cortisol secretion in humans. Patients with anorexia nervosa display concomitant HPA axis hyperactivity and increased lipolysis. We studied the effects of a lipid load on ACTH and cortisol secretion in patients with anorexia nervosa in comparison with normal subjects. Design: Eight women with anorexia nervosa (ANW; means^S.E.M.: 23.9^2.3 years of age; body mass index (BMI): 14.9^0.6 kg/m 2 ) and seven normal women (NW; 25.6^2.3 years of age; BMI: 22.8^1.9 kg/m 2 ) had FFA, ACTH, cortisol, glucose and insulin levels measured in the morning every 30 min for 180 min during i.v. saline or lipid-heparin emulsion (LHE) infusion. Results: During saline infusion, ACTH and cortisol levels decreased spontaneously in both groups, ACTH and cortisol levels in ANW being higher than in NW. LHE infusion led to increased FFA levels in both groups (P , 0.005). The ACTH and cortisol decrease in NW was more marked than during saline infusion (P , 0.05). LHE infusion in ANW was associated with a more pronounced decrease in ACTH levels than during saline infusion (P , 0.05), while cortisol levels were unchanged. At the end of the LHE infusion, a progressive decrease in FFA levels was associated with an increase in ACTH and cortisol concentrations in NW (P , 0.05) but not in ANW in whom FFA levels decreased to a lesser extent (P , 0.05). Conclusions: This study showed that corticotroph sensitivity to the inhibitory effect of an FFA load is preserved in patients with anorexia nervosa, in spite of persistent adrenal hyperactivity. European Journal of Endocrinology 154 731-738

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“…Outcome measures of patients after anesthesia with propofol, isoflurane alone or in combination with Intralipid ® for laparoscopic inguinal hernia repair. have contributed to the accentuated proinflammatory profile in these groups [34][35][36][37]. More specifically, the inflammatory responses to stress involve coordinated and complex reactions of the immune, nervous, and endocrine systems.…”

Section: Propofolmentioning

confidence: 99%

Propofol and perioperative inflammation-the Intralipid® solvent may play a role

Bandschapp¹,

Chenaud²,

Inan³

et al. 2015

Glob Anesth Perioper Med

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The inflammatory properties of propofol are still debated. Apolipoprotein A-I is involved in the inflammation. We sought to determine how propofol or its solvent Intralipid® modulate Apolipoprotein A-I and the inflammatory response after surgical stress. Patients undergoing laparoscopic inguinal hernia repair were allocated to anesthesia with propofol (n=25), isoflurane alone (n=27) or in combination with Intralipid® (n=27). Apolipoprotein A-I and inflammation were assessed before, during and after surgery. Following a decrease in all groups, Apolipoprotein A-I levels tended to recover significantly earlier when propofol or Intralipid® were given (p<0.05). Cortisol increased in the control group whereas it remained at baseline levels when lipids were given. In this study the administration of lipids, i.e. propofol or its solvent Intralipid®, in the perioperative setting was associated with a more pronounced yet rapidly recovering acute phase reaction.

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Free Fatty Acids Exert an Inhibitory Effect on Adrenocorticotropin and Cortisol Secretion in Humans

Cited by 38 publications

References 34 publications

Exogenous administration of lipids to steers alters aspects of the innate immune response to endotoxin challenge

Exogenous administration of lipids to steers alters aspects of the innate immune response to endotoxin challenge

Effects of free fatty acids on ACTH and cortisol secretion in anorexia nervosa

Propofol and perioperative inflammation-the Intralipid® solvent may play a role

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