Free circulating mircoRNAs support the diagnosis of invasive aspergillosis in patients with hematologic malignancies and neutropenia

Tolnai, Emese; Fidler, Gabor; Szász, Róbert; Rovó, László; Nwozor, Kingsley Okechukwu; Bíró, Sándor; Paholcsek, Melinda

doi:10.1038/s41598-020-73556-5

Cited by 7 publications

(6 citation statements)

References 87 publications

(104 reference statements)

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“…In a study (Tab. 3), a significant association was confirmed between invasive aspergillosis and miRNAs, miR-142-3p, -142-5p, -26b-5p and miR-21-5p (Tolnai et al, 2020). A research identified 23 miRNAs that were associated with invasive pulmonary aspergillosis (IPA), a severe opportunistic infection caused by A. fumigatus with high mortality in patients with compromised immunity (Chen et al, 2019).…”

Section: Tlr4 Tlr9mentioning

confidence: 96%

MicroRNA regulation and host interaction in response to Aspergillus exposure

Shrivastava¹,

Pandey²,

Sharma³

et al. 2022

Biocell

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Aspergillus is a group of conidial fungi, isolated from soil and litter, cause serious diseases in humans and animals. This ubiquitous fungus is prevalent in the air and inhalation of fungal spores is common. Fungal diseases from Aspergillus became a major health problem and are difficult to manage because they tend to be chronic and invasive, hard to diagnose and difficult to exterminate with antifungal drugs. Although, immune responses play vital roles in monitoring the fate of fungal infections and regulation of the immune responses against fungal infections might be an effective approach for controlling and reducing the pathological damages. Recent studies have shown that microRNAs (miRNAs) are assembly of regulators which modulates the immune responses during fungal infections through diversified cellular mechanisms. These small non-coding RNA sequences regulate gene expression, mostly at the post-transcriptional level and have emerged as the controller of gene expression of at least 30% human genes.Therefore, miRNAs might be considered as one of the potential goals in immunotherapy for fungal infections. The objective of this review is to explore the role of miRNAs in host recognition processes and understanding the modulation of regulatory pathways in response to Aspergillus exposure.

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Section: Tlr4 Tlr9mentioning

confidence: 96%

MicroRNA regulation and host interaction in response to Aspergillus exposure

Shrivastava¹,

Pandey²,

Sharma³

et al. 2022

Biocell

View full text Add to dashboard Cite

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“…Vast majority of the identified 33 miRNAs that regulate genes related to the pathogenesis of invasive aspergillosis (such as S100B, TDRD9 and TMTC1) were also linked to the finetuning of platelet activation [90]. Overexpression of miR-21-5p, miR-26-5p, miR-142-3p and miR-142-5p in cases of invasive aspergillosis in hemato-oncology patients with profound neutropenia may be applied as a promising diagnostic adjunct with sufficient accuracy and sensitivity [79].…”

Section: Mirna Fingerprints In Fungal Infectionsmentioning

confidence: 99%

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

Gaál

2024

IJMS

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MicroRNAs (miRNAs) are 19–23 nucleotide long, evolutionarily conserved noncoding RNA molecules that regulate gene expression at the post-transcriptional level. In this review, involvement of miRNAs is summarized in the differentiation and function of immune cells, in anti-infective immune responses, immunodeficiencies and autoimmune diseases. Roles of miRNAs in anticancer immunity and in the transplantation of solid organs and hematopoietic stem cells are also discussed. Major focus is put on the translational clinical applications of miRNAs, including the establishment of noninvasive biomarkers for differential diagnosis and prediction of prognosis. Patient selection and response prediction to biological therapy is one of the most promising fields of application. Replacement or inhibition of miRNAs has enormous therapeutic potential, with constantly expanding possibilities. Although important challenges still await solutions, evaluation of miRNA fingerprints may contribute to an increasingly personalized management of immune dysregulation with a remarkable reduction in toxicity and treatment side effects. More detailed knowledge of the molecular effects of physical exercise and nutrition on the immune system may facilitate self-tailored lifestyle recommendations and advances in prevention.

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“…But in a clinical study among hemato-oncology patients with profound neutropenia, free circulating miR-142-3p was significantly upregulated because of invasive aspergillosis. The reason for this difference may be related to the type of diseases [70].…”

Section: Perioperative Precision Medicinementioning

confidence: 99%

MicroRNAs: Regulators of the host antifungal immune response

2023

PPM

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Fungi pose a severe threat to human health worldwide, especially to patients with weakened immune systems. Perioperative patients are at a high risk of fungal infection and death because of the immunosuppression caused by the surgery, as well as the use of surgical instruments. Perioperative patients in ICU are at greater risk of fungal infection. Fungal infections are often difficult to identify, and the treatment is particularly challenging. A well-functioning host immune and an appropriate level of inflammation is essential for controlling fungal infections. MicroRNAs (miRNAs) play critical roles in regulating host immune function, primarily through participating in the post-transcriptional regulation of target genes. After fungal infection, miRNAs are differentially expressed in various tissues, cells, and extracellular vesicles, promoting or inhibiting antifungal effects through different mechanisms to modulate the host immune response. In addition, differentially expressed miRNAs could serve as potential biological markers for the diagnosis and treatment of fungal infections. In this review, we discuss the role and significance of miRNAs in fungal infections.

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Free circulating mircoRNAs support the diagnosis of invasive aspergillosis in patients with hematologic malignancies and neutropenia

Cited by 7 publications

References 87 publications

MicroRNA regulation and host interaction in response to Aspergillus exposure

MicroRNA regulation and host interaction in response to Aspergillus exposure

Role of microRNAs in Immune Regulation with Translational and Clinical Applications

MicroRNAs: Regulators of the host antifungal immune response

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