2007
DOI: 10.1097/mol.0b013e3282efa35b
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Free cholesterol in atherosclerotic plaques: where does it come from?

Abstract: These recent findings emphasize the importance of intraplaque hemorrhage as a contributor of free cholesterol in plaques and point to its provocative role in lesion destabilization.

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Cited by 66 publications
(59 citation statements)
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References 47 publications
(34 reference statements)
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“…Platelets have been shown to contribute substantially to atherosclerosis, 46,47 and unesterified cholesterol in RBCs (and possibly platelets) may contribute to cholesterol deposition in atherosclerosis. 48 Thus, it is possible that the platelet abnormalities in SR-BI KO described here may contribute to the enhanced atherosclerosis observed in SR-BI-deficient mice.…”
Section: Discussionmentioning
confidence: 98%
“…Platelets have been shown to contribute substantially to atherosclerosis, 46,47 and unesterified cholesterol in RBCs (and possibly platelets) may contribute to cholesterol deposition in atherosclerosis. 48 Thus, it is possible that the platelet abnormalities in SR-BI KO described here may contribute to the enhanced atherosclerosis observed in SR-BI-deficient mice.…”
Section: Discussionmentioning
confidence: 98%
“…When the thickness of the intima increases beyond just 0.5 mm, hypoxia induces ingrowth of vaso-vasorum (934). In recent years there has been growing appreciation for the potentially major destabilizing effects of these leaky, friable vessels.…”
Section: Vaso-vasorummentioning
confidence: 99%
“…Low-density lipoprotein (LDL)-cholesterol is recognized as a risk factor of atherosclerosis, hypertension, and coronary heart disease. [157][158][159] The direct effects of cholesterol on blood flow include growth of atherosclerotic plaques that reduce the lumen of coronary arteries, as well as blunted endothelium-dependent vasodilation at the coronary microcirculation level that leads to an impairment of myocardial perfusion. Indirect effects of hypercholesterolemia involve blood rheology; in fact, a high level of cholesterol may affect whole blood viscosity, platelet activation, and RBC deformability, leading again to impaired coronary circulation.…”
Section: B Hypercholesterolemiamentioning
confidence: 99%