Free-Breathing 3 T Magnetic Resonance T2-Mapping of the Heart

Heeswijk, Ruud B. van; Feliciano, Hélène; Bongard, Cédric; Bonanno, Gabriele; Coppo, Simone; Lauriers, Nathalie; Locca, Didier; Schwitter, Juerg; Stuber, Matthias

doi:10.1016/j.jcmg.2012.06.010

Cited by 81 publications

(138 citation statements)

References 21 publications

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“…For T 2 , the mean myocardial value measured with MRF was 38ms (min 34ms, max 43ms), which is consistent with the mean value obtained with the T 2 -prepared bSSFP sequence of 38ms (min 32ms, max 43ms). These measurements lie within the range of previously reported native myocardial relaxation times at 3T of T 1 from 1080-1500ms (16,18,24,38) and T 2 from 38-50ms (24,39). The mean M 0 measured in myocardium was 0.28 but exhibited wide variability across subjects (min 0.12, max 0.39).…”

Section: Human Volunteer Imagingsupporting

confidence: 85%

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

et al. 2017

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Purpose-To introduce a 2D MR Fingerprinting technique for quantification of T 1 , T 2 , and M 0 in myocardium.Methods-An ECG-triggered MR Fingerprinting (MRF) method is introduced for mapping myocardial T 1 , T 2 , and M 0 during a single breathhold in as short as four heartbeats. The pulse sequence employs variable flip angles, repetition times, inversion recovery times, and T 2 preparation dephasing times. A dictionary of possible signal evolutions is simulated for each scan that incorporates the subject's unique variations in heart rate. Aspects of the sequence design were explored in simulations, and the accuracy and precision of cardiac MRF were assessed in a phantom study. In vivo imaging was performed at 3T in eleven volunteers to generate native parametric maps.Results-T 1 and T 2 measurements from the proposed cardiac MRF sequence correlated well with standard spin echo measurements in the phantom study (R 2 >0.99). A Bland-Altman analysis revealed good agreement for myocardial T 1 measurements between MRF and MOLLI (bias 1ms, 95% limits of agreement −72 to 72ms) and T 2 measurements between MRF and T 2 -prepared bSSFP (bias −2.6ms, 95% limits of agreement −8.5 to 3.3ms). Conclusions-MRFcan provide quantitative single slice T 1 , T 2 , and M 0 maps in the heart within a single breathhold.

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Section: Human Volunteer Imagingsupporting

confidence: 85%

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

et al. 2017

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“…In this study, the T2 value correlated inversely with wall thickness as the region of interest defined by the investigator may have included left ventricular cavity or epicardial fat voxels, an effect with could produce false positive results in clinical practice [8]. The normal myocardial T2 measure was lower at 3 T (39 ± 5 ms) [14].…”

Section: T2 Mapping Sequence: Principlesmentioning

confidence: 72%

MR imaging assessment of myocardial edema with T2 mapping

Montant¹,

Sigovan

Revel

et al. 2015

Diagnostic and Interventional Imaging

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Cardiac magnetic resonance (CMR) provides a high signal-to-noise ratio, high spatial and temporal resolutions, as well as a delayed-enhancement sequence and is therefore considered a reference technique in the field of cardiac imaging. However, currently available sequences are not adequate to assess some pathologic conditions, such as myocardial edema. T2 mapping sequences generate parametric images that are based on the transverse relaxation time (T2) for each voxel. In case of edema, the T2 relaxation time is longer. This review summarizes current knowledge on CMR T2 mapping for assessing myocardial edema.

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“…High-resolution navigator-gated radial 2D T 2 maps 12 were acquired in 3 short-axis slices as a reference (see Table 1 for magnetic resonance pulse sequence details). The self-navigated isotropic 3D radial whole-heart T 2 map 11 (voxel size 1.72 x 1.72 x 1.72 = 5.1 mm 3 ) was obtained during free breathing.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, absence of ACR when using a technique that is able to detect 1R will impact on the guidance of immunosuppression. This pilot study therefore aimed to validate a novel 3-dimensional (3D) self-navigated cardiac T 2 -mapping technique with high spatial resolution (1.72 x 1.72 x 1.72 = 5.1 mm 3 ) at 3 T throughout the whole heart 11 by direct comparison with 2D T 2 -mapping at high resolution (1.25 × 1.25 × 5 = 7.8 mm 3 ) 12 and EMB-based ACR detection.…”

mentioning

confidence: 99%

Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation

Heeswijk¹,

Piccini²,

Tozzi³

et al. 2017

Transplantation Direct

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BackgroundT2 mapping is a magnetic resonance imaging technique measuring T2 relaxation time, which increases with the myocardial tissue water content. Myocardial edema is a component of acute cellular rejection (ACR) after heart transplantation. This pilot study compares in heart transplantation recipients a novel high resolution 3-dimensional (3D) T2-mapping technique with standard 2-dimensional (2D) T2-mapping for ACR detection.MethodsConsecutive asymptomatic patients (n = 26) underwent both 3D T2 mapping and reference 2D T2 mapping magnetic resonance imaging on the day of endomyocardial biopsy (EMB). 3D T2 maps were obtained at an isotropic spatial resolution of 1.72 mm (voxel volume 5.1 mm3). 2D and 3D maps were matched anatomically, and maximum segmental T2 values were compared blinded to EMB results. In addition, all 3D T2 maps were rendered as 3D images and inspected for foci of T2 elevation.ResultsT2 values of segments from 2D and reformatted 3D T2 maps agreed (p > 0.5). The highest 2D segmental T2 values were 49.9 ± 4.0 ms (no ACR = 0R, n = 18), 48.9 ± 0.8 ms (mild ACR = 1R, n = 3), and 65.0 ms (moderate ACR = 2R). Rendered 3D T2 maps of cases with 1R showed foci with significantly elevated T2 signal (T2 = 58.2 ± 3.6 ms); 5 cases (28%) in the 0R group showed foci with increased T2 values (>2 SD above adjacent tissue) that were not visible on the 2D T2 maps.ConclusionsThis pilot study in a small cohort suggests equivalency of standard segmental analysis between 3D and 2D T2-mapping. 3D T2 mapping provides a spatial resolution that permits detection of foci with elevated T2 in patients with mild ACR.

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Free-Breathing 3 T Magnetic Resonance T2-Mapping of the Heart

Cited by 81 publications

References 21 publications

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

MR imaging assessment of myocardial edema with T2 mapping

Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation

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Free-Breathing 3 T Magnetic Resonance T2-Mapping of the Heart

Cited by 81 publications

References 21 publications

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density

MR fingerprinting for rapid quantification of myocardial T1 , T2 , and proton spin density

MR imaging assessment of myocardial edema with T2 mapping

Three-Dimensional Self-Navigated T2 Mapping for the Detection of Acute Cellular Rejection After Orthotopic Heart Transplantation

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Product

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MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density

MR fingerprinting for rapid quantification of myocardial T₁ , T₂ , and proton spin density