Free and Conjugated Steroids in Maternal and Fetal Plasma in the Cow Near Term

Hoffmann, Bernd; Wagner, Waldemar; Giménez, T.

doi:10.1095/biolreprod15.1.126

Cited by 72 publications

(31 citation statements)

References 21 publications

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“…Although E 1 S is not biologically active at the nuclear estrogen-receptor compared with weakly to moderately effective E1 and highly active E 2 β [15], measurement of E 1 S in maternal plasma and assessment of its function would provide an indirect estimation of E1. During the last week of gestation, both E 1 S and E 2 β increase markedly in peripheral blood and reach peak values around parturition [12,17,18]. These prepartum rises in maternal blood result from increased activity of 17α-hydroxylase, C-17, 20-lyase and aromatase [19,20].…”

mentioning

confidence: 99%

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

et al. 2007

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Abstract. The aim of this study was to evaluate the changes in plasma concentrations of estrone sulfate (E1S) and estradiol-17β (E2β) during the peripartum period (from day 10 prepartum to day 1 postpartum) associated with and without retention of fetal membranes (RFM) in Holstein-Friesian cattle (n=42). Plasma samples were analyzed for E1S and E2β by ELISA. All parturitions were spontaneous and normal. Of 38 cattle delivering singletons, 29 had no RFM (singleton-normal group) and nine had RFM for more than 12 h (singleton-RFM group). Four cows gave birth to twins, and each twin had its own fetal membrane (FM). Two twinning cows expelled both FMs normally within 12 h (twin-normal group). In the remaining 2 twinning cows (twin-RFM group), the FM was expelled normally for one twin (first), while the FM of the other (second) was retained. There were no significant differences in the E1S concentrations or their increments from the concentrations on the preceding day between the normal and RFM groups of singleton cows on any peripartum day. The mean plasma E2β concentrations on each day from day 10 to day 3 prepartum were significantly lower (P<0.05) in the singleton-RFM group compared with the singleton-normal group; however, on days 2 and 1 prepartum, the increments in the E2β concentrations from the concentrations on the preceding days were significantly higher (P<0.05) in the singleton-RFM group than in the singleton-normal group. Thus, the plasma E1S concentrations just before parturition may not be associated with RFM. In the cows with RFM, the lower plasma E2β concentrations that were found prior to day 2 prepartum may have been associated with immature placentomes, and the rapid rise in plasma E2β within 1 to 2 days prior to calving may have produced asynchrony of placental and/or fetal maturation in relation to calving, thus resulting in RFM.

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confidence: 99%

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

et al. 2007

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“…These results show that early in pregnancy in cows that are to abort the progesterone secretion cannot be maintained and that estradiol, although it is less abundant than estrone, is a better indicator of the physiological state of pregnancy. Glencross et al (1973), Robertson (1974), Comline et al (1974) and Hoffman et al (1976) Lamond and Gaddy (1912) …”

mentioning

confidence: 99%

Steroid Hormone Levels in Beef Cows During Pregnancy Terminating in Normal Calving or Abortion and With Single or Multiple Ovulation

Adelakoun¹,

Matton²,

Dufour³

1978

Can. J. Anim. Sci.

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“…On the other hand, the concentrations of oestrogens are relatively high and vary among individuals (Challis et al, 1974;Hoffmann et al, 1976;Reimers et al, 1985). Conjugated oestrogens also exceed that of free oestrogens; however, oestradiol-17a-sulphate, but not oestronesulphate, is the major oestrogen in foetal blood (Hoffmann et al, 1976). It was suggested that oestrone (free and conjugated), which is produced and released from the cotyledons, must be reduced into oestradiol-17a when entering the foetal compartment (Hoffmann et al, 1979).…”

Section: Concentrations Of Progesterone and Oestrogens In Foetal Bloodmentioning

confidence: 99%

“…The placenta is the main source of oestrogens in the bovine pregnancy (Edqvist et al, 1973;Peterson et al, 1975;Hoffmann et al, 1976). Both oestrone and oestradiol were detected in cotyledonary and caruncular tissues from about the fourth month of gestation (Tsumagari et al, 1993).…”

Section: Oestrogen Productionmentioning

confidence: 99%

Multilevel regulation of steroid synthesis and metabolism in the bovine placenta

Nguyen

Conley

Soboleva

et al. 2012

Molecular Reproduction Devel

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SUMMARYSteroid hormones play critical roles in almost all physiological processes in male and female reproduction. In a normal pregnancy, the concentrations of steroid hormones in maternal and foetal blood vary with gestation in response to changing needs. The placenta plays a central role in producing the appropriate steroids to support the pregnancy by coordinating its own steroidogenic activity with that of the corpus luteum and responding to foetal signals. Although much is known about the steroidogenic potential of the bovine placenta, far less is known about how the placenta integrates the synthesis of steroids with their subsequent metabolism and clearance to achieve appropriate local and peripheral concentrations of steroids in maternal and foetal blood at each stage of gestation. This review focuses on the current knowledge of the temporal and spatial regulation and compartmentalization of the biochemical pathways by which potent steroid hormones are synthesized and metabolized in the bovine placenta. The aim is to increase our understanding of how the balance of synthesis and metabolism determines placental steroid output as it changes with development and differentiation, and how this is regulated in response to the variations in the foetal signals and luteal secretory activity. The review highlights knowledge gaps and suggests that mathematical modelling can help understand the effect of different levels of regulation on the steroidogenic output of an organ, such as the bovine placenta.

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Free and Conjugated Steroids in Maternal and Fetal Plasma in the Cow Near Term

Abstract: ABSTRACT

Cited by 72 publications

References 21 publications

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

Peripartum Changes in Plasma Estrone Sulfate and Estradiol-17.BETA. Profiles Associated With and Without the Retention of Fetal Membranes in Holstein-Friesian Cattle

Steroid Hormone Levels in Beef Cows During Pregnancy Terminating in Normal Calving or Abortion and With Single or Multiple Ovulation

Multilevel regulation of steroid synthesis and metabolism in the bovine placenta

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