Free and bound phenols from Cymbopogon citratus mitigated hepatocellular injury in streptozotocin-induced type 1 diabetic male rats via decrease in oxidative stress, inflammation, and other risk markers

Falode, John Adeolu; OLOFINLADE, Temidayo Blessing; FAYEUN, Gbenga Samuel; Adeoye, Akinwunmi Oluwaseun; Bamisaye, F. A.; Ajuwon, Olawale Razaq; Obafemi, Tajudeen Olabisi

doi:10.1016/j.prmcm.2023.100234

Cited by 3 publications

(5 citation statements)

References 61 publications

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“…The assay with experimental animals followed the standards established by the National Council for the Control of Animal Experimentation (CONCEA) and the Ethics Committee on Animal Use (CEUA) of the Federal University of Sergipe (UFS), complying with the minimum number of animals required for use in pre-clinical assays [ 29 , 30 ].…”

Section: Methodsmentioning

confidence: 99%

Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model

Júnior,

Aidar,

Silva

et al. 2024

Life

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(1) Background: Species of the genus Cymbopogon and its essential oil are known for their antioxidant and hypoglycemic effects. This study aimed to investigate the impact of the essential oil of Cymbopogon flexuosus (EOCF), and its major component, citral, on glycemic, lipid, antioxidant parameters, and oxidative stress in a type 1 diabetes (DM1) rat model. (2) Methods: Initially, EOCF was analyzed by Gas chromatography-mass spectrometry (GC-MS) and the antioxidant activity of EOCF and citral was evaluated. Next, male Wistar rats (3 months old, 200–250 g) induced with DM1 using Streptozotocin (STZ) were divided into four groups: negative control supplemented with an 80% Tween solution, two groups of animals supplemented with EOCF (32 mg/kg and 64 mg/kg) and with citral (32 mg/kg), and treated for 14 days. Measurements of blood glucose levels and body weight were taken; after euthanasia, biochemical markers, including lipid profile, uric acid, alanine aminotransferase (ALT), and aspartate aminotransferase (AST), were evaluated. (3) Results: The predominant compounds in EOCF were α-citral (53.21%) and neral (19.42%), constituting 72.63% citral. EOCF showed good antioxidant activity, significantly greater than citral. EOCF supplementation demonstrated a mitigating effect on glycemic, lipid, and hepatic abnormalities induced by DM1. (4) Conclusions: EOCF emerges as a promising therapeutic option for the management of DM1.

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Section: Methodsmentioning

confidence: 99%

Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model

Júnior,

Aidar,

Silva

et al. 2024

Life

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“…The chemicals present in C. citratus were obtained from the previous published works [4,8]. The name of each phytochemical was searched on the PubChem database on NCBI and each chemical structure was obtained in SMILES and SDF formats.…”

Section: Phytochemicals Structurementioning

confidence: 99%

“…In studies focusing on antidiabetic properties, C. citratus extracts have demonstrated inhibition of some carbohydrate enzymes such as alpha-glucosidase and alpha-amylase [1,2,7], with molecular docking studies reporting binding affinities of approximately -6.00 kcal/mol [2]. Additionally, research has shown that streptozotocin (STZ)-induced type 1 diabetes could be mitigated by the C. citratus extracts by improving the activity of the antioxidant enzymes, liver biomarkers, levels of malondialdehyde and glutathione thereby increasing anti-inflammatory responses, as well as reducing pro-inflammatory cytokine levels [8]. In anti-malarial studies, molecular docking simulations of C. citratus phytochemicals indicated -7.8 kcal/mol as the binding affinity of swertiajaponin for Plasmodium falciparum merozoite surface protein 1 (PfMSP1), while quercetin demonstrates significant binding affinities of 8.3 and 6.8 kcal/mol with P. falciparum circumsporozoite protein (PfCSP) and P. falciparum erythrocyte membrane protein 1 (PfEMP1) respectively [4].…”

Section: Introductionmentioning

confidence: 99%

ADME, Molecular Targets, Docking, and Dynamic Simulation Studies of Phytoconstituents of Cymbopogon citratus (DC.)

Ajayi,

Fatoki,

Alonge

et al. 2024

MEDIN

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Cymbopogon citratus (DC) Stapf., is utilized in both culinary and medicinal contexts, wherein its extracts demonstrate a range of therapeutic properties, including antidiabetic, antioxidant, and anti-inflammatory activities. This investigation aimed to computationally analyze phytochemicals of C. citratus, evaluating their pharmacokinetics and binding dynamics. The findings revealed a combination of high and low gastrointestinal absorption (GIA) for C. citratus (DC.) phytochemicals, with some exhibiting permeability across the blood-brain barrier (BBB). Xanthine dehydrogenase/oxidase (XDH) emerged as the primary human molecular target of C. citratus phytocompounds, while XDH and Matrix metalloproteinase-9 (MMP9) have central connectivity in the protein interaction network. Orientin has best binding affinity with XDH (-9.083 kcal.mol-1) and MMP9 (-9.051 kcal.mol-1). Molecular dynamic (MD) simulations indicated the favorable stability and interactions of XDH with Orientin and Quercetin, respectively. In summary, this investigation underscores the potential of twenty-six (26) in C. citratus extract to combating cancer and neurodegenerative diseases through mechanisms targeting XDH and MMP9.

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“…Lemongrass demonstrates anti-aspergillosis potential by inhibiting enzymes essential for fungal cell wall synthesis [ 4 , 5 , 6 , 7 , 8 ]. Lemongrass also shows promise in the realm of human health, with hepatoprotective effects against hepatocellular injury in diabetic rats [ 9 ], cholesterol-lowering potential by preventing gut absorption [ 10 ], and the ability to overcome doxorubicin resistance in cancer cells [ 11 ]. In the area of oral health, lemongrass combined with chlorhexidine can effectively reduce bacterial counts in microcosm biofilms, paving the way for new mouthwash formulations [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Anxiolytic, anticonvulsant, and maybe preventative qualities against Alzheimer’s disease are among the plant’s neuroprotective benefits that are linked to volatile components including citral, geraniol, and linalool [ 13 , 14 ]. As evidenced by its topical use in lowering skin erythema and edema [ 15 ] and its inclusion into chitosan bioactive films for skincare applications [ 16 ], lemongrass also has antioxidant [ 9 , 17 , 18 ] and anti-inflammatory effects. The biological activities of C. citratus have been attributed to the secondary metabolites present in both the plant matrix and essential oils.…”

Section: Introductionmentioning

confidence: 99%

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

Cortes-Torres,

López-Castillo,

Marín-Torres

et al. 2023

CIMB

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This study analyzed the chemical composition of Cymbopogon citratus essential oil from Puebla, México, assessed its antioxidant activity, and evaluated in silico protein–compound interactions related to central nervous system (CNS) physiology. GC–MS analysis identified myrcene (8.76%), Z-geranial (27.58%), and E-geranial (38.62%) as the main components, with 45 other compounds present, which depends on the region and growing conditions. DPPH and Folin–Ciocalteu assays using the leaves extract show a promising antioxidant effect (EC50 = 48.5 µL EO/mL), reducing reactive oxygen species. The bioinformatic tool SwissTargetPrediction (STP) shows 10 proteins as potential targets associated with CNS physiology. Moreover, protein–protein interaction diagrams suggest that muscarinic and dopamine receptors are related to each other through a third party. Molecular docking reveals that Z-geranial has higher binding energy than M1 commercial blocker and blocks M2, but not M4 muscarinic acetylcholine receptors, whereas β-pinene and myrcene block M1, M2, and M4 receptors. These actions may positively affect cardiovascular activity, memory, Alzheimer’s disease, and schizophrenia. This study highlights the significance of understanding natural product interactions with physiological systems to uncover potential therapeutic agents and advanced knowledge on their benefits for human health.

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Free and bound phenols from Cymbopogon citratus mitigated hepatocellular injury in streptozotocin-induced type 1 diabetic male rats via decrease in oxidative stress, inflammation, and other risk markers

Cited by 3 publications

References 61 publications

Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model

Influence of Lemongrass Essential Oil (Cymbopogon flexuosus) Supplementation on Diabetes in Rat Model

ADME, Molecular Targets, Docking, and Dynamic Simulation Studies of Phytoconstituents of Cymbopogon citratus (DC.)

Cymbopogon citratus Essential Oil: Extraction, GC–MS, Phytochemical Analysis, Antioxidant Activity, and In Silico Molecular Docking for Protein Targets Related to CNS

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