Free Amino Acids in the Cerebrospinal Fluid of Children with Febrile Seizures

Cremades, Adolfo Díaz-Bautista; Peñafiel, Rafael; Monserrat, F.; Cerón, Inés; Pérez‐Flores, Domingo

doi:10.1055/s-2008-1071277

Cited by 3 publications

(2 citation statements)

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“…Deficiency in GAB Aergic transmission has been suggested to be a factor related to FC (Loscher et al, 1981;Rating et al, 1983;Johnson et al, 1985;Pedder et al, 1988;Arias et al, 1992). However, concentrations of CSF GABA (Knight et al, 1985) or other amino acids (Cremades et al, 1989) have not explained susceptibility to FC. We evaluated the possible role of HA in regulation of FC by measuring concentrations of HA and its main metabolite, tele-methylhistamine (t-MH) in CSF of children with FC.…”

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confidence: 99%

Histamine in Cerebrospinal Fluid of Children with Febrile Convulsions

1995

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Febrile convulsions (FC) are frequent acute neurologic disturbances of childhood. The cellular and neurochemical mechanisms causing FC are unclear. Among other mechanisms, the CNS histamine (HA) has been suggested to participate in seizure control and thermoregulation. We evaluated the possible role of HA in regulation of FC by measuring HA and tele-methylhistamine (t-MH) concentrations in the cerebrospinal fluid (CSF) of children with FC. The study group consisted of 35 children treated for acute FC in the hospital. The control groups consisted of (a) feverish children without seizures (n = 23), (b) convulsive children without fever (n = 7), and (c) children with neither fever nor convulsions (n = 21). HA was assayed by high-performance liquid chromatography (HPLC) with fluorescence detection, and t-MH was measured by gas chromatography-mass spectrometry. CSF HA concentration in the group of febrile children without seizures was significantly higher (0.69 +/- 0.16 pmol/ml, mean +/- SE) than in children with FC (0.36 +/- 0.07 pmol/ml, p < 0.05, analysis of variance, ANOVA). HA concentration was 0.37 +/- 0.18 pmol/ml in the group of nonfebrile convulsive children and 0.36 +/- 0.08 pmol/ml in the nonfebrile nonconvulsive group. No statistical differences in t-MH were detected between groups. The increased susceptibility to seizures during fever may be connected to the lack of increase in CSF HA in the FC group. The data support the hypothesis that the central histaminergic neuron system may be involved in inhibition of seizures associated with febrile illnesses in childhood.

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Histamine in Cerebrospinal Fluid of Children with Febrile Convulsions

1995

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“…Segun nucstros resultados no existiria diferencia en las concentraciones de aminoacidos libres del liquido cefalorraquldeo entre recien nacidos sanos y asfixiados. Recientemente se demostn5 que tampoco expcrimentan cambios significativos como consecuencia de convulsiones febriles 10 . En la esclerosis amiotr6fica lateral se han encontrado elevadas las concentraciones de acido glutamico en el plasma y liquido cefalorraquldeo, sugiriendo una anormalidad en el metabolismo del glutamato que podrfa estar relacionada con la patogenia de la enfermedad 11 .…”

Section: Comentariounclassified

Aminoácidos libres en liquido cefalorraquídeo de recién nacidos con encefalopatía hipóxico isquémica

G²,

S³

1994

Rev. chil. pediatr.

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Free aminoacids in the cerebrospinal fluid of newborn infants with hipoxic ischemic encephalopathyCerebrospinal fluid free aminoacid (AA| composition depends on blood -CSF barrier, nervous tissue and ependima captation. It has been previously reported that in mammalian cerebral cortex a decrease of adenosinetriphosphate (ATP) is associated with an increase in asparlic acid, a deciease in glutarnic acid, aminobulyric acid and glutamine contents and that fuel deprivation causes changes in brain levels of ATP and those mentioned aminoacids. Using gas cromatography, after isobuthanol sterification of the carboxilic group and heptafluorbulyrate acylation of the amino group, free aminoacid content of cerebrospinal fluid and plasma were studied in eighl normal canlrol newborn infants and eight patients with neonatal hipoxic ischemic encephalopathy in order to detect changes in these late, but no differences of aminoacid concentration in cerebrospinal fluid were recorded among both groups. This result is in contradiction with recent reports of increased excitatory aminoacid (glutamic and aspartic acid) concentration in the cerebrospinal fluid of six asphyxiated newborn infants, and of a good ccxfelalion of these changes and neurologic prognosis of patients. More experience is needed in these respecl.(Key words; amino acids, cerebiospinal fluid cerebral ischemia, newborn.)Durante los primeros dias del periodo neonatal, los aminoa'cidos libres (AA) del plasma experimentan cambios significativos, disminuyendo en general sus concentracion.es 1 . La relaci6n entre las concentraciones de los aminoa'cidos en el plasma y el liquido cefalorraquideo (LCR) ha sido estudiada principalmente en edades mas tardias 2 " 4 y para la mayoria de ellos es menor en el segundo caso, con coeficientes individuates de relacibn que sugieren quc la composition aminoacidica de este ultimo dependen'a fundamentalmente del paso a traves de la barrera hematoencefalica, pero tambie"n de la captation porel tejido cerebral y ependimario de cada compuesto 5 . For otra parte, el glutamato y los aminoacidos relacionados, incluyendo glutamina aspartato y gama-aminobutotrato, sc cncucn- tran en concentraciones elevadas en el par6n-quima cerebral, con respecto a otros tejidos 6 y se ha sugerido que ellos juegan un importante rol como neurotransmisores 7 . Recientemente se ha seflalado tambien que, en la corteza cerebral de mamiferos, la disminucitfn de adenosina trifosfato (ATP) sc asocia con aumento del aspartato y disminucion del glutamato, aminobutotrato y glutamina y que la deprivaci6n energetica causa cafdas significativas en los niveles de ATP de estos aminoa'tidos en el cerebro 8 . La asfixia es una condici6n clinica en qae la deprivation energetica aguda esta bien rcpresentada. Nuestra hipotesis de trabajo ha sido que pudiese existir un efecto directo de la asfixia sobrc la difusi6n de aminoa'cidos libres a traves de la barrcra hematoencefalica. El prop6sito de esta investigacitfn fue medir el contcnido de aminoacidos en el plasma y el liquido cefalorra...

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Topical Review: Putative Neurotransmitter Abnormalities in Infantile Spasms: Cerebrospinal Fluid Neurochemistry and Drug Effects

Pranzatelli

1994

J Child Neurol

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The neuropharmacologic basis of infantile spasms and the mechanism by which adrenocorticotropic hormone (ACTH) exerts its therapeutic effects are unknown. This is a critical review of cerebrospinal fluid neurotransmitters or their metabolites in infantile spasms before and during treatment with ACTH, and of clinical drug trials with drugs acting on neurotransmission. Cerebrospinal fluid studies have shown lower gamma-aminobutyric acid (GABA), ACTH, and 5-hydroxyindoleacetic acid concentrations in patients with infantile spasms compared to controls, elevated lysine and glutamate, variable or no differences in homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, norepinephrine, corticotropin-releasing hormone, and beta-endorphin. Chronic treatment with ACTH in infantile spasms reduces cerebrospinal fluid GABA, beta-endorphin, and somatostatin, increases norepinephrine and tyrosine, and has variable or no effect on homovanillic acid, 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, histamine, and tryptophan. Small therapeutic trials with drugs that act through different neurotransmitters such as methysergide, alpha-methylparatyrosine, various benzodiazepine agonists, and vigabatrin lend some support to a role for GABA and monoamines in infantile spasms. These data, though promising, provide only a hint of potential neurotransmitter disturbances, and more basic and clinical data are needed.

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Free Amino Acids in the Cerebrospinal Fluid of Children with Febrile Seizures

Cited by 3 publications

References 10 publications

Histamine in Cerebrospinal Fluid of Children with Febrile Convulsions

Histamine in Cerebrospinal Fluid of Children with Febrile Convulsions

Aminoácidos libres en liquido cefalorraquídeo de recién nacidos con encefalopatía hipóxico isquémica

Topical Review: Putative Neurotransmitter Abnormalities in Infantile Spasms: Cerebrospinal Fluid Neurochemistry and Drug Effects

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