Frecuencia de ANCA positivos en una población con síntomas clínicos sugestivos de enfermedad autoinmune y la interferencia de ANA en su interpretación

Romero-Sánchez, Consuelo; Benavides-Solarte, Mario Fernando; Galindo-Ibáñez, Isabel; Ospina-Caicedo, Ana Isabel; Parra-Izquierdo, Viviana; Chila-Moreno, Lorena; Villa, Amanda; Casas-Gómez, María Consuelo; Angarita, Ignacio; Bautista-Molano, Wilson; Romero-Álvarez, Verónica; Bello-Gualtero, J.

doi:10.1016/j.reuma.2018.09.007

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…5,15 Some studies report that p-ANCA could be a "false positive" of ANA and explain the importance of antiproteinase 3 and anti-myeloperoxidase antibodies. 16 However, lung biopsy with granulomas, high titers of ANCA, and negative ANA, pushes for consideration of the biological plausibility of an overlapping syndrome between SLE and AAV.…”

Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation

Bernal-Macías

et al. 2022

Lupus

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The coexistence of systemic lupus erythematosus (SLE) and ANCA-associated vasculitis (AAV) as an overlapping syndrome is not common. Here, we report a case of a 33-year-old woman, with recent SLE diagnosis due to skin, kidney, articular, and immunologic compromise, in whom a chest CT scan showed bilateral nodules, consolidations, and tree-in-bud pattern; thoracoscopic lung biopsy revealed diffuse non-caseating granulomas, without other features of sarcoid, organizing pneumonia, or hypersensitivity pneumonitis with high positive p-ANCA titers. Overlap between SLE and AAV was a possible explanation for lupus granulomatous pneumonitis, and for this reason, a multidisciplinary meeting was held to evaluate complex patients with interstitial lung diseases patients.

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Section: Discussionmentioning

confidence: 99%

Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation

Bernal-Macías

et al. 2022

Lupus

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“…Alternativa B: La Vasculitis ANCA+ resulta menos probable dado el diagnóstico fundamentado de LES. Los resultados de c-ANCA (+) con anti PR3 negativo, en ausencia de otras manifestaciones clínicas de vasculitis, sugieren un c-ANCA falso (+) 6 .…”

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Comentario del Caso Clínico de Reumatología Básica

ROURET¹,

Ramı́rez²,

GALLO

et al. 2023

Rev chil reumatol

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Clinical and laboratory characteristics of early-onset and delayed-onset lupus nephritis patients: A single-center retrospective study

Kosałka-Węgiel,

Dziedzic,

Siwiec-Koźlik

et al. 2024

Rheumatol Int

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Background Lupus nephritis (LN) manifests systemic lupus erythematosus (SLE) and is characterized by various clinical and laboratory features. This study aimed to comprehensively evaluate the characteristics of LN patients according to the time of LN diagnosis: early-onset (LN diagnosed within one year from SLE diagnosis) vs. delayed-onset (LN diagnosed more than one year after SLE diagnosis). Methods We conducted a retrospective analysis of medical records from all SLE patients treated at the University Hospital in Kraków, Poland, from 2012 to 2022. We collected data on demographic, clinical, and laboratory characteristics, including histological findings, treatment modalities, and disease outcomes. Statistical analyses were performed to identify factors impacting LN development and prognosis. Results Among 331 LN patients, early-onset was diagnosed in 207 (62.54%) and delayed-onset was documented in 122 cases (36.86%). In 2 (0.6%) LN cases, the time of first kidney manifestation in the SLE course was unknown. Delayed-onset LN had a higher female-to-male ratio and younger age at SLE diagnosis. This group was associated with more severe clinical manifestations. In turn, studied subgroups did not differ in internist comorbidities, kidney histopathology, and family history regarding autoimmune diseases. Delayed-onset LN exhibited a higher frequency of anti-dsDNA, anti-Smith, anti-Ro, anti-RNP, and anti-cardiolipin IgG autoantibodies. During a 14-year follow-up period, 16 patients died. Mortality rate and causes of death were comparable in both analyzed subgroups. Conclusions More severe clinical manifestations in delayed-onset LN prompt strict monitoring of non-LN SLE patients to diagnose and treat kidney involvement early. Also, recognizing the higher frequency of autoantibodies such as anti-dsDNA or anti-Smith in delayed-onset LN underscores the potential value of autoantibody profiling as a diagnostic and prognostic tool.

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Frecuencia de ANCA positivos en una población con síntomas clínicos sugestivos de enfermedad autoinmune y la interferencia de ANA en su interpretación

Cited by 6 publications

References 32 publications

Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation

Systemic lupus erythematosus/ANCA-associated vasculitis overlap: An explanation for atypical lupus manifestation

Comentario del Caso Clínico de Reumatología Básica

Clinical and laboratory characteristics of early-onset and delayed-onset lupus nephritis patients: A single-center retrospective study

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