Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism
Francesca Sciarretta,
Fabio Zaccaria,
Andrea Ninni
et al.
Abstract:Immunometabolism investigates the intricate relationship between the immune system and cellular metabolism. This study delves into the consequences of mitochondrial frataxin (FXN) depletion, the primary cause of Friedreich’s ataxia (FRDA), a debilitating neurodegenerative condition characterized by impaired coordination and muscle control. By using single-cell RNA sequencing, we have identified distinct cellular clusters within the cerebellum of an FRDA mouse model, emphasizing a significant loss in the homeos… Show more
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