Franz diffusion cell and its implication in skin permeation studies

Kumar, Mohit; Sharma, Ankita; Mahmood, Syed; Thakur, Anil; Mirza, Mohd Aamir; Bhatia, Amit

doi:10.1080/01932691.2023.2188923

Cited by 27 publications

(9 citation statements)

References 130 publications

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“…In the present study, in vitro skin permeation study of NLC and NLC–chitosan hydrogel beads was conducted using the vertical Franz diffusion cell method [ 61 ]. The volume of the receiving chamber was 6.5 mL, and the effective diffusion area was 2.8 cm 2 .…”

Section: Methodsmentioning

confidence: 99%

A Novel Strategy for Topical Administration by Combining Chitosan Hydrogel Beads with Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation

Sun,

Xia,

Sun

2024

Gels

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The objective of the present study was to develop and evaluate NLC–chitosan hydrogel beads for topical administration. The feasibility of the preparation technology was verified by investigating various formulation factors and the impact of chitosan hydrogel beads on the NLC. The encapsulation efficiency of NLC–chitosan hydrogel beads was above 95% in optimized process conditions. The physical characterization of the NLC–chitosan hydrogel beads showed that the NLC was distributed within the network of the chitosan hydrogel beads. Furthermore, the incorporation of NLC into the chitosan hydrogel beads was related to the electrostatic interaction between the surface of the NLC and chitosan, which influenced the lipid ordering degree of the NLC and contributed to the stability. The stability studies showed that the retention rate of quercetin in the NLC–chitosan hydrogel beads was 88.63 ± 2.57% after 10 months of storage under natural daylight. An in vitro permeation study showed that NLC–chitosan hydrogel beads exhibited superior ability in enhancing skin permeation by hydrophobic active ingredients compared to the NLC and significantly increased skin accumulation. These studies demonstrated that the use of NLC–chitosan hydrogel beads might be a promising strategy for the delivery of hydrophobic active ingredients in topical administration.

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Section: Methodsmentioning

confidence: 99%

A Novel Strategy for Topical Administration by Combining Chitosan Hydrogel Beads with Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation

Sun,

Xia,

Sun

2024

Gels

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“…Sol-gel-based nanocarriers were prepared by using the "cold method," schematically represented in Figure 13 [38,39]. Poloxamers 407 and 188 were mixed in the required quantity of distilled water and stirred on a magnetic stirrer for 4 h at 300 rpm to control the formation.…”

Section: Methods Of Preparing Sol-gel-based Nanocarriers Of Terbinafi...mentioning

confidence: 99%

Thermo-Responsive Sol-Gel-Based Nano-Carriers Containing Terbinafine HCl: Formulation, In Vitro and Ex Vivo Characterization, and Antifungal Activity

Bajwa,

Tabassam,

Hameed

et al. 2023

Gels

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The current research aims to create a sol-gel-based nanocarrier containing terbinafine formulated for transdermal delivery of the drug into the skin. Sol-gel-based nanocarriers were prepared via the cold method using poloxamer-188, poloxamer-407, and distilled water. The prepared formulation was examined for pH, gelation temperature, Fourier transform infrared spectrophotometer (FTIR) analysis, thermal stability analysis, X-ray diffraction (XRD), scanning electron microscopy (SEM), particle size analysis, zeta potential, and anti-microbial activity. The in-vitro drug release study of F1 was found to be 94%, which showed greater drug release as compared to F2 and F3. The pH of the formulation was found to be within the range applicable to the skin. The gelation temperature was detected at 28 °C. The SEM images of formulations have spotted various particles well-segregated from each other. Analysis of formulations showed a mean globule size diameter of 428 nm, zeta potential values of 0.04 mV, refractive index (1.329), and viscosity (5.94 cP). FTIR analysis confirmed various functional groups’ presence in the prepared formulation. Thermal analysis has confirmed the stability of the drug within the prepared formulation. The growth of inhibition was found to be 79.2% in 60 min, which revealed that the prepared formulation has shown good permeation from the membrane. Hence, the sol-gel-based nanocarrier formulation of terbinafine was successfully developed and evaluated.

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“…Because of its compact, lipid-rich composition, the stratum corneum serves as an effective barrier, preventing most substances from entering. 132,133 Certain substances, however, can get inside the skin via a variety of pathways, including intercellular, transcellular, and appendageal. Intercellular permeation occurs between keratinocytes via the lipid matrix, while transcellular permeation occurs through the cells themselves.…”

Section: Challenges Associated With Topical Delivery Of Asiaticosidementioning

confidence: 99%

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

Kumar,

Mahmood

et al. 2024

RSC Pharm.

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Franz diffusion cell and its implication in skin permeation studies

Cited by 27 publications

References 130 publications

A Novel Strategy for Topical Administration by Combining Chitosan Hydrogel Beads with Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation

A Novel Strategy for Topical Administration by Combining Chitosan Hydrogel Beads with Nanostructured Lipid Carriers: Preparation, Characterization, and Evaluation

Thermo-Responsive Sol-Gel-Based Nano-Carriers Containing Terbinafine HCl: Formulation, In Vitro and Ex Vivo Characterization, and Antifungal Activity

Nanotechnology-driven wound healing potential of asiaticoside: a comprehensive review

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