Frankincense – therapeutic properties

Al-Yasiry, Ali Ridha Mustafa; Kiczorowska, Bożena

doi:10.5604/17322693.1200553

Cited by 109 publications

(95 citation statements)

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“…In addition, other constituents of low percentage have been detected such as hexyl caproate (0.75%), heptanoic acid octyl ester (0.49%), lauryl acetate (0.46%), 1,8-cineole (0.33%) and cymene (32%). This was in agreement with Al-Yasiry and Kiczorowska who demonstrated that the major constituent of frankincense oil was octyl acetate [37] (Table 1, Fig. 1).…”

Section: Results Of Gc/ms Analysissupporting

confidence: 92%

Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus

Hosny

Elhadidy²,

Sawie

et al. 2020

Clin Phytosci

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Background: The current objective is to evaluate the effect of frankincense oil on the convulsions and the associated neurochemical alterations produced in pilocarpine-induced status epilepticus rat model. Methods: Rats were divided randomly into: control, status epilepticus rat model and rat model of status epilepticus pretreated with frankincense oil daily for 5 days before pilocarpine treatment. On the fifth day, after pilocarpine injection, rats were observed to evaluate the severity of seizures for 2 h. The oxidative stress parameters malondialdehyde, reduced glutathione and nitric oxide, the proinflammatory cytokines interleukin-6 and interleukin-1β and acetylcholinesterase were determined in the cortex, hippocampus and striatum. Dopamine, norepinephrine and serotonin were measured in the cortex and striatum. Results: The status epilepticus model exhibited repetitive seizures in the form of generalized tonic-clonic convulsions after 30 min. of pilocarpine injection. This was associated with a significant increase in the levels of malondialdehyde and nitric oxide and a significant decrease in reduced glutathione in the three regions. A significant increase was also observed in interleukin-1β, interleukin-6 and acetylcholinesterase. In the cortex and striatum, a significant decrease was recorded in monoamine levels. Pretreatment of rat model of status epilepticus with frankincense oil decreased the severity of seizures that appeared in the form of tremors and facial automatisms and prevented the increase in malondialdehyde, nitric oxide, interleukin-1β, interleukin-6 and acetylcholinesterase and the decrease in reduced glutathione induced by pilocarpine in the studied brain regions. Frankincense oil failed to restore the decreased level of cortical serotonin and dopamine. In the striatum, frankincense oil improved the levels of serotonin and norepinephrine but failed to restore the decreased dopamine levels. Conclusion: It is clear from the present results that frankincense oil reduced the severity of seizures induced by pilocarpine. This could be mediated by its potent antioxidant and anti-inflammatory effects.

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Section: Results Of Gc/ms Analysissupporting

confidence: 92%

Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus

Hosny

Elhadidy²,

Sawie

et al. 2020

Clin Phytosci

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“…In traditional medicine, frankincense has a unique place amongst remedies for the treatment of many disorders (dermatological, gastric, hepatic, rheumatoid arthritis, etc.) [1].…”

Section: Introductionmentioning

confidence: 99%

In Vitro Antimicrobial Activity of Frankincense Oils from Boswellia sacra Grown in Different Locations of the Dhofar Region (Oman)

et al. 2020

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Frankincense essential oils from Boswellia sacra have been commonly used to treat microbial infections from as early as the 11th century. The main feature of the plant is its gum resin, from which it is possible to obtain essential oils. In the present study, we focused on the comparative study of the oils extracted from the resins of three different Boswellia sacra cultivars (Najdi, Sahli and Houjri). From each of frankincense resin three successive essential oil samples (Grade 1, Grade 2, Grade 3) were obtained. Houjri gum resin gave the lowest percentage (5%) of total essential oil content but showed the maximum number of volatile components in all three grades. Najdi Grade 2 essential oil showed a minimum inhibitory concentration (MIC) of 52 mg/mL toward relevant pathogens Staphylococcus aureus and Pseudomonas aeruginosa, and samples from Grade 2 of Sahily and Houjiri were particularly active against a dermatological strain Propionibacterium acnes, displaying MIC values of 0.264 and 0.66 mg/mL, respectively. Data obtained from in vitro studies showed that all essential oils had a significant antifungal effect against Candida albicans and Malassezia furfur, showing MIC values ranging from 54.56 to 0.246 mg/mL. This work aims to increase the number of substances available in the fight against pathogens and to combat the phenomenon of antibiotic resistance, encouraging the use of alternative resources, especially in non-clinical settings (farms, food processing, etc.).

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“…Geranium essential oil could eradicate enterococcal biofilm at a concentration of 150 mg/mL without bacteria developing resistance to it, thus could be a possible alternative to other antimicrobials during endodontic procedures [37]. Frankincense was reported to have anti-inflammatory and antibacterial effects [38]. Mountain savory has been proved to be highly active against methicillin-resistant Staphylococcus aureus (MRSA), Salmonella typhimurium and L. monocytogenes [39][40][41].…”

Section: Discussionmentioning

confidence: 99%

Essential Oils with High Activity against Stationary Phase Bartonella henselae

Shi

Zhang

2019

Antibiotics

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Bartonella henselae is a fastidious Gram-negative intracellular bacterium that can cause cat scratch disease, endocarditis in humans and animals, as well as other complications, leading to acute or chronic infections. The current treatment for Bartonella infections is not very effective presumably due to bacterial persistence. To develop better therapies for persistent and chronic Bartonella infections, in this study, with the help of SYBR Green I/PI viability assay, we performed a high-throughput screening of an essential oil library against the stationary phase B. henselae. We successfully identified 32 essential oils that had high activity, including four essential oils extracted from Citrus plants, three from Origanum, three from Cinnamomum, two from Pelargonium, and two from Melaleuca, as well as frankincense, ylang-ylang, fir needle, mountain savory (winter), citronella, spearmint, elemi, vetiver, clove bud, allspice, and cedarwood essential oils. The minimal inhibitory concentration (MIC) determination of these 32 top hits indicated they were not only active against stationary phase non-growing B. henselae but also had good activity against log-phase growing B. henselae. The time-kill assay showed 13 active hits, including essential oils of oregano, cinnamon bark, mountain savory (winter), cinnamon leaf, geranium, clove bud, allspice, geranium bourbon, ylang-ylang, citronella, elemi, and vetiver, could eradicate all stationary phase B. henselae cells within seven days at the concentration of 0.032% (v/v). Two active ingredients, carvacrol and cinnamaldehyde, of oregano and cinnamon bark essential oils, respectively, were shown to be very active against the stationary phase B. henselae such that they were able to eradicate all the bacterial cells even at the concentration ≤ 0.01% (v/v). More studies are needed to identify the active components of some potent essential oils, decode their antimicrobial mechanisms, and evaluate their activity against Bartonella infections in animal models.

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Frankincense – therapeutic properties

Cited by 109 publications

References 0 publications

Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus

Effect of frankincense oil on the neurochemical changes induced in rat model of status epilepticus

In Vitro Antimicrobial Activity of Frankincense Oils from Boswellia sacra Grown in Different Locations of the Dhofar Region (Oman)

Essential Oils with High Activity against Stationary Phase Bartonella henselae

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