Frankincense and myrrh suppress inflammation via regulation of the metabolic profiling and the MAPK signaling pathway

Abstract

Frankincense and myrrh are highly effective in treatment of inflammatary diseases, but lacking of the therapy mechanisms. We undertook this stuty to evaluate the effects on Adjuvant-induced Arthritis (AIA) rats and to explore the underlying mechanisms by analyzing the metabolic profiling and signaling pathway evaluated by expression of inflammatory cytokines, c-jun and c-fos and corresponding phosphorylation levels. The results stated the elevated expression levels of TNFα, PGE2, IL-2, NO, and MDA in serum and swelling paw of AIA rats were significantly decreased after treatment, which exerted more remarkable inhibitive effects of combined therapy. The metbolic profiling of plasma and urine were clearly improved and twenty-one potential biomarkers were identified. Moreover, the inhibited effects of five bioactive components on cytokine transcription in PHA stimulated-PBMC showed the MAPK pathway might account for this phenomenon with considerable reduction in phosphorylated forms of all the three MAPK (ERK1/2, p38 and JNK) and down regulation of c-jun and c-fos.

Frankincense and myrrh and their bioactive compounds ameliorate the multiple myeloma through regulation of metabolome profiling and JAK/STAT signaling pathway based on U266 cells

“…Frankincense and myrrh, classical traditional Chinese medicine, are commonly used in Chinese medicine as anti-inflammatory and analgesia drugs. Vitro studies have shown that frankincense, which has been commonly believed the efficacy substance is boswellic acid, have anti-inflammatory activity [2], analgesic [3], immunosuppressive and antitumor activities [4]. The main components in myrrh are volatile oils, including monoterpenoid and sesquiterpenoids, having the same effect as frankincense [5][6][7][8][9].…”

Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response

“…MAPK pathway is responsible for the regulation of cytokine and chemokine responses [23]. The present study showed that LPS could significantly increase the phosphorylation of MAPK and NFkB, and elevated the serum levels of TNF-a and IL-6, which were significantly decreased by Sarcandra glabra and lycopene treatment.…”

A discovery of screening markers for rheumatoid arthritis by liquid chromatography mass spectrometry: A metabolomic approach

“…way. 57 It has been reported that lysoPE (18:1(9Z)/0:0) was lower in adjuvant-induced arthritic rats than in controls. In our results, lysoPE (18:1(9Z)/0:0) levels were higher in the RA group than in the HC group.…”