Framingham Risk Score and Estimated 10-Year Cardiovascular Disease Risk Reduction by a Short-Term Yoga-Based LifeStyle Intervention

Yadav, Rashmi; Yadav, Raj Kumar; Sarvottam, Kumar; Netam, Ritesh

doi:10.1089/acm.2016.0309

Cited by 29 publications

(17 citation statements)

References 27 publications

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“…Medical doctors constantly observed closely and interacted with the participants for the first two weeks at IHC. This allowed us to assess the effectiveness with good compliance, which was noted in our previous studies as well ( 21 – 24 , 26 , 27 , 29 , 45 ). Also, for better study compliance, we intentionally added one more time point at the 4 th week to evaluate the adherence of the participants to the recommended yoga program at their home based intervention.…”

Section: Methodsmentioning

confidence: 83%

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Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Sharma

Yadav²,

Khadgawat³

et al. 2022

Front. Med.

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IntroductionObesity is one of the major global problems in today's world, both in children, and the adult age group. Current evidence suggests obesity alters the expression of various genes related to oxidative stress, inflammation, and aging. In recent times complementary therapy like yoga-based lifestyle intervention (YBLI) is used as an adjunct therapy to modern medicine. This study examines the efficacy of 12 weeks of yoga-based lifestyle intervention with standard care (SC) on the expression of genes related to oxidative stress, inflammation, and aging in obese adults.MethodsThis was a two-arm parallel randomized control trial implemented at Integral Health Clinic (IHC), an outpatient facility that regularly conducted YBLI programs for the prevention of lifestyle diseases like obesity and diabetes in the Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi. Blood samples at baseline and weeks 2,4, and 12 were collected from 72 adults (male n = 21; female n = 51) of age 20–45 years with a body–mass index (BMI) of 25–35 kg/m2 who were randomized to receive either a 12-week SC (n = 36) or YBLI (n = 36). SC included recommendations for the management of obesity as per Indian guidelines including a low-calorie individualized diet and physical activity. Asana (physical postures), pranayama (breathing exercises), and meditation were all part of the YBLI. Primary outcomes were relative fold change in the expression of genes associated with oxidative stress [Nuclear factor-kappa B (NF-Kappa B)], inflammation [Tumor necrosis factor-α (TNFα), interleukin-6 (IL-6)], and aging [human telomerase reverse transcriptase (TERT)] in peripheral blood mononuclear cells between the two groups at week-12.ResultsThere were no significant changes in fold change of TERT, IL-6, and NF-kappa B between the groups at week 12. The relative fold change of TERT was significantly greater in the YBLI group (p = <0.0001) vs the SC group at 2 weeks. The relative fold change of TNF α was significantly lower at week 12 in YBLI though the change was not continuous and reliable. Within both groups, TERT expression was significantly increased at week 2 though the change was greater in the YBLI group (p < 0.0001). TNF α gene expression was significantly lower at weeks 2 and 4, compared to baseline level, in the SC group but it increased at week 12.ConclusionThe results while did not confirm our hypothesis, are important to share with the scientific society, to be able to improve prospective study designs and find optimal time/intervention/biological marker settings for this highly important scientific field. The results are suggestive of a positive impact of YBLI and SC on the fold change of aging-related TERT gene in obesity, though the benefit was not evident till week 12. However, the results should be evaluated with caution and in light of other published studies. To better understand the positive effects of YBLI on oxidative stress, inflammation, and aging-related gene expression in obesity, larger studies are recommended.

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Section: Methodsmentioning

confidence: 83%

“…The intervention is delivered to a group of six to eight participants at a time, allowing them ample time to interact with the experts (medical doctors, yoga experts, and dietitians). The YBLI used in this study has been pretested and published previously (21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

mentioning

confidence: 99%

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Sharma

Yadav²,

Khadgawat³

et al. 2022

Front. Med.

Self Cite

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“…However, the finding was contrary to the study done by R. Yadav et. al [37], where two week of a yoga-based lifestyle intervention can reduce the predicted CVD risk score by 11%. Meanwhile, a previous study on civil servants in South-Western Nigeria using the WHO prediction chart showed that those who were physically inactive had a 2.4 times higher risk in developing CVD as compared to those who were physically active [38].…”

Section: Discussionmentioning

confidence: 99%

Frequent Eating Out and 10-Year Cardiovascular Disease Risk: Evidence from a Community Observatory in Malaysia

Ang

Ismail

Kassim

et al. 2022

BioMed Research International

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Despite increasing mortality rates from cardiovascular diseases (CVDs) in low- and middle-income countries, information on the estimation of 10-year CVD risk remains to be sparse. Therefore, this study was aimed at predicting the 10-year CVD risk among community dwellers in Malaysia and at identifying the association of distal (socioeconomic characteristics) and proximal (lifestyle practices) factors with 10-year CVD risk. We calculated the 10-year CVD risk score among 11,897 eligible respondents from the community health survey conducted by the South East Asia Community Observatory (SEACO) using the Framingham risk score (FRS). The findings indicate that 28% of respondents have a high chance of having CVD within the next ten years. After adjusting for the age of respondents, demographic and socioeconomic factors such as gender, ethnicity, marital status, education, income, and occupation had an association with the 10-year CVD risk. In addition, frequent eating out had an association with 10-year CVD risk, while physical activity was found to have no association with predicted CVD risk. CVD remained among the top five mortality causes in Malaysia. Health promotion strategies should emphasize the importance of having home-cooked meals as a healthy dietary behavior, to reduce the mortality rate among Malaysians due to CVDs.

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“…Many of the workers in health care [15,16] have suggested the increasing role of spirituality specially in the field of gerontology and management of elderly and seriously geriatric patients. It is possible that as humans become matured with age, they leans towards the spiritual [17]. A yoga based life style modification has lead to tangible improvement in the cardiovascular risk factors in a specific cohort and emphasized on role of yoga and spiritual counseling in reducing the health risks through preventive strategies [13].…”

Section: Discussionmentioning

confidence: 99%

Models of Illness and how they help in Holistic Diagnosis for all Doctors -A Brief Review and New Concepts

Bailoor¹

2017

JCMAH

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The area of spirituality and faith in doctors is a highly debated domain. We have two extreme schools one in which doctors believe that all faith is mumbo jumbo and only science can heal. Another school takes a more humane view of patients being a bundle of rationality and beliefs and feel that combination of both spirituality and science can afford a more complete healing. Many of the healers today keep an open mind and take a moderate view of utilizing spirituality in specific perplexing chronic diseases. In this introductory paper a case is made for bio-psychosocio-spiritual model of illness for doctors to weigh and consider.

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Framingham Risk Score and Estimated 10-Year Cardiovascular Disease Risk Reduction by a Short-Term Yoga-Based LifeStyle Intervention

Abstract: This yoga-based lifestyle intervention program significantly reduced the CVD risk, as shown by lowered FRS and estimated 10-year CVD risk. Further testing of this promising intervention is warranted in the long term.

Cited by 29 publications

References 27 publications

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Transcriptional modulation of inflammation, and aging in Indian obese adults following a 12-week yoga-based lifestyle intervention: A randomized controlled trial

Frequent Eating Out and 10-Year Cardiovascular Disease Risk: Evidence from a Community Observatory in Malaysia

Models of Illness and how they help in Holistic Diagnosis for all Doctors -A Brief Review and New Concepts

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