BackgroundManual deconstruction—an alternative to mechanical demolition—is a crucial technique in the building industry that facilitates a circular economy for the built environment and achieves sustainable development goals (SDGs). However, the current body of literature lacks a thorough grasp of the OHS (occupational health and safety) hazards related to the deconstruction process. The current work closes this scholarly gap by outlining the deconstruction process as phases and sets of activities and highlighting potential health and safety hazards throughout different activities and phases.MethodsThe study uses numerous case studies and applies a descriptive case study technique to gather and analyze primary data from hundreds of photos and notes from over 40 field visits. The primary data are first used to prepare a comprehensive process map of deconstruction. Six construction safety experts and four industrial hygiene experts were then interviewed to identify and characterize health and safety hazards in images representative of the deconstruction activities.ResultsA taxonomy of OHS hazards for deconstruction was developed based on identifying 35 unique safety and 51 unique health hazards. Significant safety hazards in deconstruction activities include “struck‐by,” “trip, slip, and fall” hazards, and “lack of personal protective equipment.” Major health hazards include ergonomic concerns, respiratory diseases, and eye strain.DiscussionThe study highlights the occupational health and safety issues faced by the deconstruction trade with a granularity rarely covered in existing literature. The assessments can be helpful for OHS practitioners to identify potential health and safety improvements across various deconstruction phases.