Framework invasion by laryngeal carcinoma

Gregor, R. T.; Hammond, Kate

doi:10.1016/0002-9610(89)90027-5

Cited by 27 publications

(20 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ossified cartilage also lacks the enzymatic inhibitors to tumor invasion like tumor angiogenesis factor inhibitor and collagenase inhibitor found in healthy cartilage, increasing its vulnerability to invasion. 15,26,28 Observational studies have shown that in the early stages, laryngeal framework invasion occurs primarily at the lower third of the thyroid cartilage and the upper edge of the cricoid ring which corresponds to the muscular attachment points. As stated earlier, susceptibility to invasion at these points has to do with the natural deficiency in the perichondrium at areas of muscular attachment.…”

Section: Cartilaginous Barriers To Tumor Spreadmentioning

confidence: 99%

Functional Anatomy and Oncologic Barriers of the Larynx

Mor¹,

Blitzer²

2015

Otolaryngologic Clinics of North America

View full text Add to dashboard Cite

Section: Cartilaginous Barriers To Tumor Spreadmentioning

confidence: 99%

Functional Anatomy and Oncologic Barriers of the Larynx

Mor¹,

Blitzer²

2015

Otolaryngologic Clinics of North America

View full text Add to dashboard Cite

“…Thus, the sites of attachment of the strongest membranes, such as the anterior commissure tendon, are also the most frequent sites of invasion. Invasion of the cartilage framework invariably takes place at the site of ossified or calcified cartilage (172). Non-ossified cartilage is resistant to tumor infiltration due to its capacity to release proteins that inhibit tumor angiogenetic factor and collagenases (173).…”

mentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Abstract.Background: Multi-step cancerogenesis guides laryngeal cancer onset and it includes a wide variety of pre-cancerous lesions that are macroscopically challenging to identify and distinguish from initial cancerous foci. Since the treatment of laryngeal cancer and its precursor lesions has a great impact on important laryngeal basic functions, early detection and preoperative assessment are important for a curative and function-preserving therapy. Nowadays, despite the high number of more advanced diagnostic techniques and methods, unfortunately, it is not uncommon for different clinicians to use different nomenclature or to identify different stage for the same laryngeal lesion. From these observations, it is obvious that an instrument offering the possibility to detect precancerous lesions, early cancerous lesions, and satellite foci or second primaries would be the key to improving management and outcome in laryngeal patients. Object. Different modalities of diagnostic techniques of laryngeal lesions exist. Rather than difference between benign and obvious malignant diseases, more difficult is to detect the presence of precancerous epithelial alterations. Not all tests achieve the same diagnostic accuracy, hence this meta-analysis of literature aimed to synthesize the validity of each single diagnostic technique in identifying and staging laryngeal disease. Methods: A systematic review of literature was led searching for articles mentioning the following terms including their various combinations to maximize the yield: larynx, laryngeal precancerous lesions, laryngeal cancer, white light (WL) endoscopy, stroboscopy, contact endoscopy (CE), autofluorescence (AF), ultrasound (US), narrow band imaging (NBI), computed axial tomography (CAT), magnetic resonance imaging (MRI), positron emission tomography (PET), CAT/PET. Then, a quantitative analysis was carried on for paper published after 2005 onward, reporting a minumun series of 10 patients each study, declaring sensitivity and specificity of each diagnostic system. Results: The search identified 7215 publications, of which 3616 published after 2005, with a final results of a total of 214 articles stratified and included by our selection criteria. 42 out of 214 articles were selected for quantitative synthesis. 25 out of 41 studies had a quality score of ≥ 6 (good), 16 presented a score between 4 and 5 (fair). While objections can be raised about the pooling of different diagnostic procedures under the same group and the high level of heterogeneity in the meta-analyses, the inclusion of over 4400 laryngeal lesions makes the results fairly robust. Conclusions: A comprehensive overview of the most recent advances in laryngeal imaging technology combined with all of the information needed to interpret findings and successfully manage patients with voice disorders can be found herein. With these data, clinicians can riskstratify patients and select proper examination modalities in order to provide appropriate care. Moreover, study limitations, together with p...

show abstract

“…The pattern of laryngeal cartilage invasion has been studied by Kirchner et al, who found that invasion almost invariably occurred in the areas of ossifi cation in the lower third of the thyroid cartilage and the upper edge of the cricoid ring in the early stages of tumor spread [11,14]. The reason for this is not completely understood; however, invasion of ossifi ed cartilage has been attributed primarily to increased vascularization, by which most carcinoma cells initially reach metaplastic bone.…”

mentioning

confidence: 97%

“…Ossifi cation of the laryngeal cartilage usually begins after the second or third decade of life, although direct correlation with age is poor [7,[11][12][13]. Ossifi cation of the thyroid cartilage has been noted to follow a defi ned, symmetrical pattern which usually begins at the posterior border near the root of the inferior horn, spreading along the inferior border, and reaching the midline where there is usually a separate center of ossifi cation [7,11,12].…”

mentioning

confidence: 99%

“…Ossifi cation of the thyroid cartilage has been noted to follow a defi ned, symmetrical pattern which usually begins at the posterior border near the root of the inferior horn, spreading along the inferior border, and reaching the midline where there is usually a separate center of ossifi cation [7,11,12]. It is known that tumor invasion of laryngeal cartilage is more possibly to occur in metaplastic cartilage than in non-metaplastic cartilage [7].…”

mentioning

confidence: 99%

See 1 more Smart Citation