Frailty Syndrome in Patients with Carotid Disease: Simplifying How We Calculate Frailty

Pandit, Viraj; Zeeshan, Muhammad; Nelson, Peter R.; Hamidi, Muhammad Hanis Muhmad; Jhajj, Sandeep; Lee, Ashton; Trinidad, Bradley; Goshima, Kaoru R.; Horst, Vernon; Weinkauf, Craig; Wei, Zhou; Tan, Tze‐Woei

doi:10.1016/j.avsg.2019.10.001

Cited by 22 publications

(14 citation statements)

References 28 publications

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“…After applying the in-and exclusion criteria, 2,686 articles were excluded. Out of the remaining 41 full-texts, 27 studies were excluded because of using a single-domain frailty tool, and six for miscellaneous reasons (i.e., full-text not accessible or no primary data presented), resulting in eight articles that were included in this systematic review (20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Resultsmentioning

confidence: 99%

“…After quality assessment, six studies were identified as having low risk of bias (22)(23)(24)(25)(26)(27) and two studies as having moderate risk of bias (20,21) (Table 1). All studies focused on pre-operative frailty status (Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Seven were retrospective cohort studies (20,(22)(23)(24)(25)(26)(27) and one was a prospective cohort study (21). All studies were performed in the USA and six studies (20,(22)(23)(24)(25)27) used the same national database from the National Surgical Quality Improvement Project (NSQIP) to retrieve their data. The three different frailty tools used by the included studies are presented in Table 3 and consist of the Clinical Frailty Scale (CFS) to prospectively collect patient-reported data, and the Risk Analysis Index (RAI) and Modified Frailty Index (MFI) to retrospectively collect data, retrieved from medical records.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Seven out of eight studies (20,(22)(23)(24)(25)(26)(27) included the preoperative prevalence of frail and non-frail CEA patients and were therefore included in the pooled prevalence analysis (Figure 2). The pooled prevalence for pre-operative frailty was 22.07% (95% CI: 16.35-27.79), with a high level of heterogeneity (I 2 =100%, P<0.01).…”

Section: Prevalence Of Pre-operative Frailtymentioning

confidence: 99%

“…The pooled prevalence for pre-operative frailty was 22.07% (95% CI: 16.35-27.79), with a high level of heterogeneity (I 2 =100%, P<0.01). After excluding the studies that used the same database (20,(23)(24)(25)27), the pooled prevalence for pre-operative frailty was estimated at 23.9% (95% CI: 12.98-34.82) with a high level of heterogeneity (I 2 =100%, P<0.01).…”

Section: Prevalence Of Pre-operative Frailtymentioning

confidence: 99%

See 4 more Smart Citations

Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Benjamens¹,

Bokkers²,

Zeebregts³

et al. 2021

Ann Transl Med

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Carotid endarterectomy (CEA) is a surgical treatment option to prevent ischemic cerebrovascular accidents. Patients that present with pre-operative frailty might have an elevated risk for unfavorable outcomes after the CEA. A systematic search, using Medline, Embase, Web of Science and Cochrane Database, was performed for relevant literature on frailty in patients undergoing CEA. The study protocol was registered with PROSPERO (CRD42020190345). Eight articles were included. The pooled prevalence for pre-operative frailty was 23.9% (95% CI: 12.98-34.82). A difference in the incidence of complications between frail and non-frail patients (6.4% vs. 5.2%, respectively) and a difference in hospital length of stay [2 (IQR: 2-3) days vs. 1 (IQR: 1-2) day, respectively] were described. The 30-day mortality after CEA was 0.6% for non-frail patients, 2.6% for frail patients, and 4.9% for very frail patients (P<0.001). For 3-year mortality, a >1.5-fold increased risk was found for frail patients (OR 1.7, 95% CI: 1.4-2.0) and a >2.5-fold increased risk for very frail patients (OR 2.6, 95% CI: 2.2-3.1). In conclusion, this review shows the impact of frailty on outcome after CEA. Pre-operative frailty assessment with a validated, multi-domain tool should be implemented in the clinical setting as it will provide information on post-operative surgical outcomes and mortality risk but also frailty trajectory and cognitive decline.

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Section: Resultsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Prevalence Of Pre-operative Frailtymentioning

confidence: 99%

Section: Prevalence Of Pre-operative Frailtymentioning

confidence: 99%

See 3 more Smart Citations

Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Benjamens¹,

Bokkers²,

Zeebregts³

et al. 2021

Ann Transl Med

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Abdominal hysterectomy and high frailty score are associated with complications among older patients

Wainger

Yazdy

Handa

2021

Intl J Gynecology & Obste

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As the US population of older adults increases, the number of older hysterectomy patients will increase. 1 Evidence demonstrates a wide range of postoperative outcomes in older adults of the same chronologic age. Consequently, frailty has been examined as a way to better predict which older patients have higher risk for poor surgical outcomes. 2 Frailty has been conceptualized as an "age-related, multidimensional state of decreased physiologic reserves that results in diminished resiliency, loss of adaptive capacity, and increased vulnerability to stressors". 3 From a practical perspective, frailty has

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Prevalence of frailty in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis

Wang

et al. 2022

Ageing Research Reviews

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Frailty Syndrome in Patients with Carotid Disease: Simplifying How We Calculate Frailty

Cited by 22 publications

References 28 publications

Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Role of pre-operative frailty status in relation to outcome after carotid endarterectomy: a systematic review

Abdominal hysterectomy and high frailty score are associated with complications among older patients

Prevalence of frailty in patients with lower extremity peripheral arterial disease: A systematic review and meta-analysis

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