Frailty predicts long‐term mortality in elderly subjects with chronic heart failure

Cacciatore, Francesco; Abete, Pasquale; Mazzella, Francesca; Viati, Luisa; Della-Morte, David; D’Ambrosio, Daniele; Gargiulo, Gaetano; Testa, Gianluca; Santis, Domenico De; Galizia, Gianluigi; Ferrara, Nicola; Rengo, F.

doi:10.1111/j.1365-2362.2005.01572.x

Cited by 268 publications

(227 citation statements)

References 45 publications

(72 reference statements)

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“…In the study of Spanish population, the coexistence of HF and frailty syndrome contributed to a rise in one-year mortality rate (16.9% in the group with frailty syndrome vs. 4.8% in the group without frailty syndrome, p < 0.001), and rehospitalizations (20.5% in the group with frailty syndrome vs. 13.3% in the group without frailty syndrome, p = 0.01) [17]. Similar results were obtained in the 12-year observation of Italian patients, in whom frailty syndrome was a predictor of a higher mortality rate [20].…”

Section: Frailty Syndromesupporting

confidence: 75%

Czynniki wpływające na rehospitalizacje pacjentów z niewydolnością serca

Szeląg¹,

Kuśnierz

Łoboz-Rudnicka³

et al. 2017

Folia Cardiologica

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Heart failure (HF) is at present an important clinical problem. Hospitalization of HF patients causes that they have a much less favorable prognosis, and their successive rehospitalizations significantly affect the course of the disease and further treatment. The main reason for readmission to hospital is HF exacerbation, which from the pathophysiological point of view is associated with an elevated pressure in the pulmonary circulation. Factors affecting rehospitalization can be divided into: cardiac-related factors such as ischemia, atrial fibrillation, and uncontrolled hypertension, non-cardiac factors including coexisting diseases (especially chronic obstructive pulmonary disease, infections), patient--related factors (nonadherence/noncompliance, self-care, frailty-syndrome, depression, cachexia) and healthcare system-related factors (nonadherence of physicians, therapeutic nihilism, insufficiency of interdisciplinary care system in the field of patients' therapy and education). Rehospitalization of HF patients is a complex, multifactorial and not fully understood problem. An integrated interdisciplinary care system, which covers patients' therapy, education, self--assessment and self-control may reduce the mortality rate and number of rehospitalizations for all reasons and for HF.

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Section: Frailty Syndromesupporting

confidence: 75%

Czynniki wpływające na rehospitalizacje pacjentów z niewydolnością serca

Szeląg¹,

Kuśnierz

Łoboz-Rudnicka³

et al. 2017

Folia Cardiologica

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“…41 The risk for individual mortality can be predicted better by frailty than by chronological age, and mortality among older people with chronic heart failure increases with frailty. 42,43 Frailty seems to be a predictor for case complexity as measured by the INTERMED instrument. 19,44 An evaluation of frailty may be of great interest for those oncologists who want to identify older patients likely to develop severe toxicity and severe side-effects in response to aggressive treatment.…”

Section: Frailty Has Consequencesmentioning

confidence: 99%

Frailty: an emerging concept for general practice

Lepeleire¹,

Iliffe²,

Mann³

et al. 2009

Br J Gen Pract

187

140

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“…Indeed, the vast majority of people aged ≥65 years is characterized by a condition of comorbidity and disability [6,32]. Both conditions lead to a frailty state and, therefore, to high drug consumption [5,29].…”

Section: Introductionmentioning

confidence: 99%

Physical activity is inversely related to drug consumption in elderly patients with cardiovascular events

Cacciatore

Mazzella

Viati

et al. 2013

Eur Rev Aging Phys Act

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Elderly patients with cardiovascular events are characterized by high drug consumptions. Whether high drug consumptions are related to physical activity is not known. In order to examine whether physical activity is related to drug consumption in the elderly, patients older than 65 years (n= 250) with a recent cardiovascular event were studied. Physical activity was analyzed according to the Physical Activity Scale for the Elderly (PASE) score and related to drug consumption. PASE score was 72.4±45.0 and drug consumption was 8.3± 2.2. Elderly patients with greater comorbidity took more drugs (8.7±2.1) and are less active (PASE=64.4±50.6) than patients with Cumulative Illness Rating Scale severity score higher than 1.8 than those with a score lower than 1.8 (76.3±41.4, p <0.05, and 8.0±2.0, p=0.006, respectively). Multivariate analysis correlation confirmed that PASE score is negatively associated with drug consumption (β = −0.149, p = 0.031), independently of several variables including comorbidity.Thus, physical activity is inversely related to drug consumption in elderly patients with cardiovascular events. This inverse relationship may be attributable to the high degree of comorbidity observed in elderly patients in whom poor level of physical activity and high drug consumption are predominant.

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Frailty predicts long‐term mortality in elderly subjects with chronic heart failure

Cited by 268 publications

References 45 publications

Czynniki wpływające na rehospitalizacje pacjentów z niewydolnością serca

Czynniki wpływające na rehospitalizacje pacjentów z niewydolnością serca

Frailty: an emerging concept for general practice

Physical activity is inversely related to drug consumption in elderly patients with cardiovascular events

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