Frailty influences the vascular responsiveness of elderly individuals with chronic heart failure

Rech, Daiana Aparecida; Silveira, Lucas Santos da; Martins, Edgar Manoel; Roque, Ana Beatriz Alves de Oliveira; Althoff, Amanda; Maiorana, Andrew; Vieira, Ariany Marques; Karsten, Marlus

doi:10.1016/j.mvr.2022.104316

Cited by 5 publications

(5 citation statements)

References 46 publications

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“…Of the included studies, 13 studies were considered of having a high risk of bias [ 7 , 31 , 32 , 39 , 41 , 43 , 46 , 52 , 53 , 60 , 61 , 63 , 64 ], 16 as moderate risk of bias [ 18 , 29 , 33 , 36 , 37 , 42 , 44 , 45 , 48 – 50 , 55 , 56 , 58 , 59 , 62 ], and 12 studies had a low risk [ 28 , 30 , 34 , 35 , 38 , 40 , 47 , 51 , 54 , 57 , 65 , 66 ] (Table S2).…”

Section: Resultsmentioning

confidence: 99%

Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis

Prokopidis,

Ishiguchi,

Jordan

et al. 2024

Aging Clin Exp Res

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Background Heart failure (HF) and frailty are accompanied by a bidirectional relationship, sharing common risk factors including elevated levels of natriuretic peptides and inflammation. The aim of this study was to compare biomarkers associated with poor clinical outcomes, that is, plasma brain natriuretic peptide (BNP), N-terminal-pro B-type natriuretic peptide (NT-proBNP), and C-reactive protein (CRP) in patients with HF and frailty vs. patients with HF without frailty. Methods From inception until July 2023, PubMed, Scopus, Web of Science, and Cochrane Library a systematic literature search was conducted. To evaluate whether frailty is linked with greater levels of BNP, NT-proBNP, and CRP, a meta-analysis using a random-effects model was used to calculate the pooled effects (CRD42023446607). Results Fifty-three studies were included in this systematic review and meta-analysis. Patients with HF and frailty displayed significantly higher levels of BNP (k = 11; SMD: 0.53, 95%CI 0.30–0.76, I2 = 86%, P < 0.01), NT-proBNP (k = 23; SMD: 0.33, 95%CI 0.25–0.40, I2 = 72%, P < 0.01), and CRP (k = 8; SMD: 0.30, 95%CI 0.12–0.48, I2 = 62%, P < 0.01) vs. patients with HF without frailty. Using meta-regression, body mass index (BMI) and age were deemed potential moderators of these findings. Conclusions Frailty in HF is linked to increased concentrations of BNP, NT-proBNP, and CRP, which have been epidemiologically associated with adverse outcomes. The increased risk of NYHA III/IV classification further emphasizes the clinical impact of frailty in this population.

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Section: Resultsmentioning

confidence: 99%

Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis

Prokopidis,

Ishiguchi,

Jordan

et al. 2024

Aging Clin Exp Res

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“…Seven studies assessed the prevalence of polypharmacy [20][21][22][23][24][25][26] and six studies assessed the number of medications [14][15][16][17][18][19] administered by patients with HF and frailty vs. without frailty. Detailed characteristics of the included studies are presented in Tables 1 and 2.…”

Section: Descriptive Resultsmentioning

confidence: 99%

“…Of the final 72 studies identified as eligible for inclusion in our study, 58 articles included only data related to specific medications rather than polypharmacy rates and total number of medications, while one study defined frailty as short physical performance battery score below 6. Overall, 13 studies were included in this systematic review and meta-analysis (Figure 1) [14][15][16][17][18][19][20][21][22][23][24][25][26] .…”

Section: Literature Searchmentioning

confidence: 99%

“…Eight studies used Fried's criteria for the definition of frailty [14][15][16][20][21][22][23][24] , one study used the Rockwood score 26 , one study the Korean FRAIL scale (K-FRAIL) 17 , one study the FRAIL scale 19 , one study the frail-VIG index 25 , and one study the clinical frailty scale 18 . Polypharmacy was generally defined as the presence of 5 or more medications, although one study defined it as more than 5 24 .…”

Section: Definition Of Frailty and Polypharmacymentioning

confidence: 99%

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What is the association of polypharmacy with frailty in heart failure? A systematic review and meta-analysis

Prokopidis,

Testa,

Veronese

et al. 2024

JFSF

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This systematic review and meta-analysis aimed to explore the differences in the number of prescribed medications and polypharmacy risk between patients with heart failure (HF) and frailty vs. those with HF but without frailty. Eligible studies included observational or experimental studies in patients aged ≥50 years. Thirteen studies met the criteria and were included in the final analysis. Patients with frailty and HF exhibited a higher risk of polypharmacy (OR: 1.87, 95% CI 1.72 – 2.04, I 2 = 0%, P < 0.01) compared to those without frailty. Results remained significant after adjusting for comorbidity status. Additionally, patients with frailty and HF were prescribed more medications compared to those without ( k = 6; MD: 1.43, 95% CI 0.31 – 2.55, I 2 = 94%, P = 0.01), with a high degree of heterogeneity. However, results were non-significant after adjustment for comorbidity status. Patients with HF and frailty have a higher need of polypharmacy compared to those without frailty, which may increase the risk of potentially inappropriate medications (PIM). Investigating the real-world prevalence of PIM may support clinicians in their routine assessment as part of a comprehensive management strategy in patients with HF and frailty.

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“…During the development of heart failure, cellular oxidative damage leads to the accumulation of ROS. When the accumulation of ROS exceeds the body's clearance capacity, the risk of frailty increases (Rech DA, Silveira LSD, Martins EM, et al, 2022). Revel (Revel F, Gilbert T, Roche S, et al, 2015) found that oxidative stress biomarkers, especially glutathione peroxidase and glutathione, can predict the process of cognitive decline in patients with AD or other neurodegenerative diseases.…”

Section: Oxidative Stressmentioning

confidence: 99%

Research Progress on Cognitive Frailty in Elderly Patients with Heart Failure

Xu,

Zhang,

Ding

et al. 2023

JIMR

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With the deepening of aging in our country, frailty, as a common elderly syndrome, has become a new prominent public health problem. Cognitive frailty, as a component of frailty, often coexists with heart failure, leading to a variety of adverse clinical outcomes. However, most of the current studies are devoted to cross-sectional investigation of the incidence of cognitive frailty in patients with heart failure and discussion of the correlation between the two, and the studies on its pathogenesis and intervention measures are scattered, and the review literature is relatively lacking. Moreover, in-depth study of the pathogenesis of such patients and exploration of effective intervention measures are extremely necessary to improve the quality of life and prognosis of patients. Therefore, this paper expounds the pathophysiological mechanism and summarizes the intervention measures in combination with relevant recent research, aiming to provide reference for the development of intervention programs for people with heart failure combined with cognitive frailty.

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Frailty influences the vascular responsiveness of elderly individuals with chronic heart failure

Cited by 5 publications

References 46 publications

Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis

Association between natriuretic peptides and C-reactive protein with frailty in heart failure: a systematic review and meta-analysis

What is the association of polypharmacy with frailty in heart failure? A systematic review and meta-analysis

Research Progress on Cognitive Frailty in Elderly Patients with Heart Failure

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