Frailty indices in patients undergoing surgical resection of brain metastases: a systematic review

Roy, Joanna M.; Bangash, Ali Haider; Skandalakis, Georgios P.; Bowers, Christian A.

doi:10.1007/s10143-023-02174-2

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…Examining the OS of patients aged 65 years and older compared to those younger than 65 years following resection of multiple BM, we found no significant difference (p = 0.917). This reinforces previous research suggesting that frailty as a state of increased vulnerability resulting from different age-related conditions may hold greater predictive value than chronological age alone [32,33].…”

Section: Functional Status Not Rpa Class or Age Is Associated With Ov...supporting

confidence: 88%

“…Despite the prognostic significance of RPA classification in studies involving single brain metastasis resection, our analysis did not reveal significant differences in OS between RPA classes (p = 0.635) following resection and adjuvant therapy for BM [13]. It has been noted that the RPA classification may overly emphasize age as a predictive factor [29][30][31][32]. Examining the OS of patients aged 65 years and older compared to those younger than 65 years following resection of multiple BM, we found no significant difference (p = 0.917).…”

Section: Functional Status Not Rpa Class or Age Is Associated With Ov...contrasting

confidence: 68%

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Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

Niedermeyer,

Schmutzer-Sondergeld,

Weller

et al. 2024

J Neurooncol

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Purpose This study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs). Methods This retrospective, monocentric analysis included clinical data from all consecutive BM patients, who underwent simultaneous resection of ≥ 2 BMs between January 2018 and May 2023. Postoperative neurological and functional outcomes, along with perioperative complications, as well as survival data were evaluated. Results A total of 47 patients, with a median age of 61 years (IQR 48–69), underwent 73 craniotomies (median 2; range 1–3) for resection of 104 BMs. Among patients, 80.8% presented with symptomatic BMs, causing focal neurological deficits in 53% of cases. Gross total resection was achieved in 87.2% of BMs. Karnofsky Performance Scale (KPS) scores improved in 42.6% of patients, remained unchanged in 46.8%, and worsened in 10.6% after surgery. Perioperative complications were observed in 29.8% of cases, with transient complications occurring in 19.2% and permanent deficits in 10.6%. The 30-days mortality rate was 2.1%. Logistic regression identified eloquent localization (p = 0.036) and infratentorial craniotomy (p = 0.018) as significant predictors of postoperative complications. Concerning overall prognosis, patients with permanent neurological deficits post-surgery (HR 11.34, p = 0.007) or progressive extracranial disease (HR: 4.649; p = 0.006) exhibited inferior survival. Conclusion Microsurgical resection of multiple BMs leads to clinical stabilization or functional improvement in most patients. Although transient complications do not affect overall survival, the presence of persistent neurological deficits (> 3 months post-surgery) and progressive extracranial disease negatively impact overall survival. This highlights the importance of careful patient selection for resection of multiple BMs.

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Section: Functional Status Not Rpa Class or Age Is Associated With Ov...supporting

confidence: 88%

Section: Functional Status Not Rpa Class or Age Is Associated With Ov...contrasting

confidence: 68%

Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

Niedermeyer,

Schmutzer-Sondergeld,

Weller

et al. 2024

J Neurooncol

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Bibliometric analysis of research trends in the relationship between frailty and neoplasms over the past decade

Chen,

Zhong

et al. 2024

Support Care Cancer

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Background The relationship between frailty and neoplasms has attracted increasing attention from researchers in recent years. This study aims to identify current research hotspots and status in this field through bibliometric and visualization analysis. Methods Literature on the relationship between frailty and neoplasms, meeting the inclusion criteria, was collected from the Core Collection. Bibliometric analysis and visualization were performed using WoS, VOSviewer, and CiteSpace. Results Our study included 7410 documents on frailty and neoplasms, authored by 43,605 researchers from 9478 institutions across 115 countries, and published in 2067 journals. The USA emerged as the most productive and influential country in this field, with 3059 publications and 89,319 citations. The University of Texas MD Anderson Cancer Center and Mayo Clinic were recognized as the most productive institution and the institution with the highest citation count, respectively. The Journal of Geriatric Oncology was the leading publisher. Kirsten K Ness and James L Kirkland were identified as the most productive and most cited authors, respectively. Cluster analysis identified five key areas: body condition and nutrition, quality of life, frailty, mortality and care, and the elderly and frailty. Conclusion The relationship between frailty and neoplasms remains a contentious and frequently discussed topic. Our findings indicate that research primarily focuses on cancer, the elderly, clinical trials, adverse health outcomes, frailty assessment, and nutrition.

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Frailty indices in patients undergoing surgical resection of brain metastases: a systematic review

Cited by 2 publications

References 42 publications

Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis

Bibliometric analysis of research trends in the relationship between frailty and neoplasms over the past decade

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