Frailty Index for prediction of surgical outcome in ovarian cancer: Results of a prospective study

Inci, Melisa Guelhan; Anders, Louise; Woopen, Hannah; Richter, Rolf; Guzel, Duygu; Armbrust, Robert; Sehouli, Jalid

doi:10.1016/j.ygyno.2021.02.012

Cited by 26 publications

(34 citation statements)

References 28 publications

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“…shown to have a higher risk of severe complications in a study by Di Donato et al 29 Inci et al showed that frail patients had five times higher risk of complications. 30 In a study comparing women with residual disease 1-10 mm after PDS with women with R0 after IDS by Ghirardi et al, the rate of complications was 15%, which is similar to our rates. The women treated with PDS had a higher rate of both intraoperative complications (16.9% vs 1.3%) and postoperative complications (28.8% vs 2.0%) compared with those treated with IDS.…”

Section: Discussionsupporting

confidence: 91%

“…The rate of severe complications differs in published studies, from 19.7% in a study by Fagotti et al to 4.9% in a study by Di Donato et al 28,29 The differences may depend on patient selection, surgical approach and how complications are reported and measured. According to previous studies, frailty is common in advanced ovarian cancer patients and results in a higher degree of severe complications and an affected survival 18,30 . Patients where a high frailty score was combined with an intermediate/high SCS were shown to have a higher risk of severe complications in a study by Di Donato et al 29 Inci et al showed that frail patients had five times higher risk of complications 30 …”

Section: Discussionmentioning

confidence: 98%

“…According to previous studies, frailty is common in advanced ovarian cancer patients and results in a higher degree of severe complications and an affected survival. 18,30 Patients where a high frailty score was combined with an intermediate/high SCS were…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Complications after advanced ovarian cancer surgery—A population‐based cohort study

Palmqvist

Michaëlsson

Staf³

et al. 2022

Acta Obstet Gynecol Scand

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 98%

See 1 more Smart Citation

Complications after advanced ovarian cancer surgery—A population‐based cohort study

Palmqvist

Michaëlsson

Staf³

et al. 2022

Acta Obstet Gynecol Scand

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“…So far, scant evidence has underscored the association between the deficit accumulation model of Rockwood and the main clinical outcomes in older adults with cancer. Inci et al performed a prospective study enrolling 144 patients with ovarian cancer undergoing cytoreductive surgery, evaluating the predictive value of the frailty index on severe postoperative complications and overall survival [28]. The main results showed that a frailty index >0.26 (OR 3.64, 95% CI: 1.34-9.85, p = 0.01) was highly predictive of severe postoperative complications, whereas a frailty index >0.15 (HR 1.87, 95% CI: 1.01-3.47, p = 0.048) showed poor survival during a median follow-up observation of 37.6 months.…”

Section: Frailty and Cancer Outcomesmentioning

confidence: 99%

Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review

Muzyka

Tagliafico

Serafini

et al. 2022

Cancers

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Background: The interplay between different neuropsychiatric conditions, beyond dementia, in the presence of a diagnosis of cancer in older adults may mediate patients’ fitness and cancer-related outcomes. Here, we aimed to investigate the presence of depression, sleep disturbances, anxiety, attitude, motivation, and support in older adults receiving a diagnosis of cancer and the dimension of frailty in order to understand the magnitude of the problem. Methods: This review provides an update of the state of the art based on references from searches of PubMed between 2000 and June 2021. Results: The evidence obtained underscored the tight association between frailty and unfavorable clinical outcomes in older adults with cancer. Given the intrinsic correlation of neuropsychiatric disorders with frailty in the realm of cancer survivorship, the evidence showed they might have a correlation with unfavorable clinical outcomes, late-life geriatric syndromes and higher degree of frailty. Conclusions: The identification of common vulnerabilities among neuropsychiatric disorders, frailty, and cancer may hold promise to unmask similar shared pathways, potentially intercepting targeted new interventions over the spectrum of cancer with the delivery of better pathways of care for older adults with cancer.

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“…To estimate the extent of the disease and resectability, different imaging modalities are used. To predict the risk of major complications concerning extensive cytoreduction, numerous patient-related factors need to be considered, which include the use of frailty indexes [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Accuracy of Pretreatment Ultrasonography Assessment of Intra-Abdominal Spread in Epithelial Ovarian Cancer: A Prospective Study

et al. 2021

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The aim of this study was to test the accuracy of ultrasonography performed by gynecological oncologists for the preoperative assessment of epithelial ovarian cancer (EOC) spread in the pelvis and abdominal cavity. A prospective, observational cohort study was performed at a single tertiary cancer care unit. Patients with suspected EOC were recruited and underwent comprehensive transvaginal and abdominal ultrasonography performed by a gynecological oncologist. Sixteen intra-abdominal localizations and parameters were assessed using ultrasonography and compared with surgical-pathological status (reference standard). Sensitivity, specificity, positive and negative predictive values, and overall accuracy were calculated. Differences were analyzed using Fisher’s exact and chi-square tests. Ultimately, we included 132 patients (median age 62 years), of whom 67% were in stage IIIC–IVB and 72% had serous cancer. Overall prediction accuracies for the involvement of the omentum, small bowel mesentery root, and frozen pelvis, and detecting ascites were >90%. Detecting the involvement of the pelvis peritoneum, liver and spleen hilum, and rectosigmoid colon, and predictions of disease stage and residual disease had overall accuracies of 80–90%. The lowest accuracy was for involvement of the abdominal peritoneum (69%) and diaphragm peritoneum (right 71%; left 75%) and surgical complexity prediction (77%). Stratification of results by presence or absence of ascites revealed significantly higher specificity of ultrasonography (clinically meaningful) for assessments of the abdominal/pelvic peritoneum, spleen hilum, and rectum wall, if there were ascites. A gynecological oncologist, experienced in surgery and sonology, performing comprehensive ultrasonography on patients with EOC can accurately detect intraperitoneal lesions and recognize critical disease manifestations and predict stage, surgical complexity, and residual disease, which allow accurate qualification of patients for primary debulking surgery or neoadjuvant chemotherapy.

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Frailty Index for prediction of surgical outcome in ovarian cancer: Results of a prospective study

Cited by 26 publications

References 28 publications

Complications after advanced ovarian cancer surgery—A population‐based cohort study

Complications after advanced ovarian cancer surgery—A population‐based cohort study

Neuropsychiatric Disorders and Frailty in Older Adults over the Spectrum of Cancer: A Narrative Review

Accuracy of Pretreatment Ultrasonography Assessment of Intra-Abdominal Spread in Epithelial Ovarian Cancer: A Prospective Study

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