Frailty in elderly people with chronic kidney disease

Franco, Maria Eugenia Portilla; Molina, Fernando Tornero; Gregório, Pedro Gil

doi:10.1016/j.nefroe.2016.12.005

Cited by 7 publications

(11 citation statements)

References 30 publications

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“…Chronic kidney disease (CKD) and end-stage renal disease (ESRD) are the most significant age-related renal diseases, reported in elderly patients (Portilla Franco, Tornero Molina, & Gil Gregorio, 2016;Poveda et al, 2017). Eradication of H. pylori is likely to have a protective effect against CKD (hazard ratio: 0.69) (Wang et al, 2016a).…”

Section: Renal Abnormalitiesmentioning

confidence: 99%

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Zendehdel

Roham

2020

Molec Gen & Gen Med

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This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. AbstractHelicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non-gastric pathologies.Aging-associated cellular and molecular alteration can increase the risk of other pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, respiratory and renal dysfunction, and cancer in geriatric patients, more than other age groups.This review article highlights some of the most common old age diseases and the role of H. pylori infection as a risk factor to worsen the conditions, presented by the molecular evidences of these associations. These studies can help clinicians to understand the underlying pathogenesis of the disease and identify high-risk patients, aiding clearer diagnosis and treatment.

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Section: Renal Abnormalitiesmentioning

confidence: 99%

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Zendehdel

Roham

2020

Molec Gen & Gen Med

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“…Frailty is a common comorbidity in CKD patients, and its prevalence increases with age ( 55 ). Data support the concept of a spiral of frailty, whereby elder patients with CKD are predisposed to inactivity and frailty ( 56 ), and frailty can cause further inactivity and disability ( 57 ). However, while disease and aging contribute to frailty, there are also potentially reversible factors, such as inflammation ( 58 ).…”

Section: Discussionmentioning

confidence: 73%

Daily Step Counts in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies

et al. 2022

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BackgroundPhysical inactivity is an essential factor in the prognosis of patients with chronic kidney disease (CKD). Daily step count is a straightforward measure to assess physical activity levels. Understanding the step counts among different CKD stages is essential to change sedentary behavior.ObjectivesThis systematic review and meta-analysis aimed to investigate the daily step counts in patients with CKD at a different stage.DesignA systematic review and meta-analysis.Data SourcesThe literature search was performed in PubMed, Embase, and Web of Science from inception to November 3rd, 2021.Review MethodsObservational studies (cross-sectional, case-control, or cohort studies) reported specific values of step counts in CKD patients by the wearable device were included. A random-effects model was used to pool the data. Subgroup analysis explored differences in outcomes by stage of CKD. Heterogeneity between studies was assessed using the χ2 test of Cochrane's Q statistic. A contour-enhanced funnel plot was conducted to investigate publication bias. Univariate and multivariate meta-regression was conducted to examine possible sources of heterogeneity.ResultsTwenty-eight articles were identified and used for quantitative analysis. The result showed that the daily step count in patients with CKD was 4642.47 (95% CI: 4274.18–5010.76), and significantly lower than the healthy population. Subgroup analysis revealed that the step counts decreased before dialysis, dropped to a freezing point at the hemodialysis phase, and increased after kidney transplantation. Meta-regression analysis showed that daily step counts were relatively higher in the Americas or younger than 60 or kidney transplant recipients.ConclusionThe status of daily step counts in patients with CKD decreases with CKD severity and increases after kidney transplantation. Although studies have begun to focus on strategies to improve step counts in patients with CKD, future studies should focus more on step counts in pre-dialysis patients and changing their physically inactive lifestyle early to alleviate deteriorating renal function.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?RecordID=291551, identifier: CRD42021291551.

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“…On the contrary, Fructuoso et al (23) showed that quality of life in patients with hemodialysis are lower than the normal people.…”

Section: Discussionmentioning

confidence: 96%

Health related quality of life and cost of illness in hemodialysis patients attending teaching hospitals: evidence from a developing country

Ghoddoosi-Nejad,

Ebrahimi,

SharifZadeh

et al. 2024

Preprint

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Introduction: Chronic kidney diseases and treatment protocols and procedures including hemodialysis affect one’s life style, health status and nevertheless socio-economic status of the patients. We aimed to assess the health related quality of life and cost of illness in hemodialysis patients. Methods and materials: This study conducted in a two phases. First we assessed the quality of life of the patients undergo hemodialysis and then Cost of Illness (COI) was estimated. Researchers used census method for sampling and all patients attended teaching hospitals were included in the study. KDQOL-SF used for assessing quality of life of the patients and COI checklist was used for estimating costs of them during the study. Results: 38 (76%) of the participants were male and other were female (12, 2%). Also 76% of the patients were married. Mean score of quality of life was 221.2 ± 17.31. Direct medical costs of every patient with hemodialysis was calculated 268.71$ and total cost for every patients was estimated for 2,050.09$ per year for receiving hemodialysis care on average. Significant relationship found between the quality of life and gender and employment status. Also, there was a significant relationship between the total costs of the studied hemodialysis patients and the variables of employment status and job type. (α≤0.05) Conclusion: Although the quality of life score of hemodialysis patients was assessed relatively high, due to the fact that most of the treatment costs included overhead and indirect costs from the patient's out of pocket payments, it is recommended to the health authorities to take decisions such as setting up more dialysis centers to reduce these costs, and developing supportive subsidiary plans for these type of patients.

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Frailty in elderly people with chronic kidney disease

Cited by 7 publications

References 30 publications

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Daily Step Counts in Patients With Chronic Kidney Disease: A Systematic Review and Meta-Analysis of Observational Studies

Health related quality of life and cost of illness in hemodialysis patients attending teaching hospitals: evidence from a developing country

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