Frailty in elderly ICU patients in Greece: a prospective, observational study

Papageorgiou, Dimitris; Gika, Eleni; Kosenai, Konstantina; Tsironas, Konstantinos; Avramopoulou, Lamprini; Sela, Ervina; Mandila, Christina

doi:10.21037/atm.2018.02.03

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…The advantages of LS are its simplicity and objectivity, which are essential in clinical use. Additionally, consistent with the results of the aforementioned trials with other frailty assessment tools [2, 5, 25–27, 38], LS was an independent risk factor of in-hospital mortality in our analysis. Of note, we also found that the association between frailty and mortality was influenced by the presence of treatment limitations, i.e., patients with treatment limitations had high aOR of death regardless of their frailty status.…”

Section: Discussionsupporting

confidence: 91%

“…Recently, there has been a growing understanding that frailty may be a more robust predictor of vulnerability than chronological age alone [24]. Several studies have reported that frailty is associated with both poor short-term [2, 5, 25–27] and long-term [3, 4, 28–30] outcomes in patients in the ICU. Therefore, several statements support the use of frailty in the triage [31–36], as an entrance to the ICU, while making decisions with respect to treatment limitations [37], as an exit from the ICU.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between community walking ability and in-hospital mortality in elderly patients with sepsis: a single-center retrospective cohort study

et al. 2019

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Purpose To examine the association of a simple frailty assessment, Life Space (LS), with in-hospital mortality in elderly patients with sepsis. Methods We used data from a single hospital between 2014 and 2017. We included elderly patients (age ≥ 65 years) admitted to the intensive care unit (ICU) with sepsis, as defined by sepsis-3 criteria. Frailty assessment was based on a patient’s ability to independently go out of the house before the ICU admission. We termed this dichotomous score as Life Space. The primary outcome was in-hospital mortality. Logistic regression was used to investigate the association of LS with each outcome after adjusting for age, sex, and Sequential Organ Failure Assessment score. Results Of the 335 participants included in the final analysis, 121 (36%) were classified as frail. LS-positive patients had a higher in-hospital mortality (adjusted odds ratio (aOR) 2.32; 95% confidence interval (CI) 1.36–3.96; P = 0.002) than did LS-negative patients. We observed similar patterns in six sets of sensitivity analyses after accounting for different confounders. In subgroup analyses, significant interactions were observed in participants with versus those without treatment limitations (aOR 1.02 vs. 2.66, P for interaction = 0.042). Conclusions In this single-center study, frailty assessed by LS was independently associated with a higher in-hospital mortality. Electronic supplementary material The online version of this article (10.1186/s40560-019-0385-1) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Relationship between community walking ability and in-hospital mortality in elderly patients with sepsis: a single-center retrospective cohort study

et al. 2019

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“…In the first study, CFS was used evaluating frailty in older patients admitted in an intensive care unit. In this study 25% of the patients were categorized as frail, based on information adapted by the patients’ family or caregiver [ 45 ]. In the second one, CFS was used to assess the frailty status of hospitalized elderly patients with atrial fibrillation.…”

Section: Discussionmentioning

confidence: 99%

Validation of the revised 9-scale clinical frailty scale (CFS) in Greek language

et al. 2021

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Background Among many screening tools that have been developed to detect frailty in older adults, Clinical Frailty Scale (CFS) is a valid, reliable and easy-to-use tool that has been translated in several languages. The aim of this study was to develop a valid and reliable version of the CFS to the Greek language. Methods A Greek version was obtained by translation (English to Greek) and back translation (Greek to English). The “known-group” construct validity of the CFS was determined by using test for trends. Criterion concurrent validity was assessed by evaluating the extent that CFS relates to Barthel Index, using Pearson’s correlation coefficient. Both inter-rater and test–retest reliability were assessed using intraclass correlation coefficient. Results Known groups comparison supports the construct validity of the CFS. The strong negative correlation between CFS and Barthel Index (rs = − 0,725, p ≤ 0.001), supports the criterion concurrent validity of the instrument. The intraclass correlation was good for both inter-rater (0.87, 95%CI: 0.82–0.90) and test-retest reliability (0.89: 95%CI: 0.85–0.92). Conclusion The Greek version of the CFS is a valid and reliable instrument for the identification of frailty in the Greek population.

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“…The prevalence of frailty in community samples ranges from 6 to 11.1% [8][9][10]. Inpatients have a higher prevalence of frailty, ranging from 25 to 65.62% [11,12].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated factors for frailty among elder patients in China: a multicentre cross-sectional study

et al. 2020

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Background: To date, most previous studies of frailty among hospitalized elderly Chinese patients have been conducted based on small samples, which cannot represent the elderly patient population. The aim of this study was to identify the prevalence of and risk factors for frailty among elderly patients in China. Study design and setting: This cross-sectional study surveyed 9996 elderly patients from 6 tertiary-level hospitals in China. The prevalence of frailty among patients from selected wards was surveyed by trained investigators. A mixed-effects Poisson regression model was used to analyse the factors associated with frailty among elderly patients. Results: The mean age of all subjects was 72.47 ± 5.77 years. The prevalence rate of frailty in this study was 18.02%. After adjustments were made for the confounding effect of the clustering of hospital wards, a mixed-effects Poisson regression model showed that the associated factors of frailty included the following: age (

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Frailty in elderly ICU patients in Greece: a prospective, observational study

Cited by 7 publications

References 14 publications

Relationship between community walking ability and in-hospital mortality in elderly patients with sepsis: a single-center retrospective cohort study

Relationship between community walking ability and in-hospital mortality in elderly patients with sepsis: a single-center retrospective cohort study

Validation of the revised 9-scale clinical frailty scale (CFS) in Greek language

Prevalence and associated factors for frailty among elder patients in China: a multicentre cross-sectional study

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