Frailty assessment in ANCA-associated vasculitis: current evidence and remaining uncertainties

Sarcoidosis and frailty: recognizing factors that foster holistic resilience

“…High SVI overall and its sub-domain scores correlate two-fold with increased mortality incidence in pulmonary sarcoidosis [8 && ]. Conflicting results from frailty investigations between similar patient cohorts with ANCA-associated vasculitis [24][25][26] highlight the impact of variations across frailty measures and influences such as social vulnerability.…”

Prescribing Immunosuppressive Treatment for Older People with Glomerular Diseases: Time to Assess Frailty?

“…In this study of 83 subjects older than 65 years with AAV, the risk of death doubled with each higher unit of the Clinical Frailty Scale score, 19 although a subsequent smaller study did not show this association. 20 The study by McGovern et al 19 also added to concerns on the adverse effects of cumulative steroid dose exposure in the older AAV population. Although there were no significant differences in the cumulative glucocorticoid dose exposure between the more and less frail groups, there were more adverse events in the frail group (1.4 versus 1.1 events per patient) and a greater proportion of frail group patients had one or more adverse event(s) (81% versus 58%).…”

Frailty and antineutrophil cytoplasmic antibody‐associated vasculitis: What do we know?

“…4,7 In reverse, the two studies that utilized the HFRS and Claims Frailty Index, respectively, did not conclude statistically significant associations between frailty status and mortality outcomes. 6,9 All of the studies illustrated no differences among AAV patients of varying frailty status in terms of progression toward kidney failure. Unsurprisingly, it was also concurred that frailty status is significantly associated with the occurrence of adverse events during follow-up, in particular infection-related complications.…”

“…We performed a scoping search in PubMed, Web of Science, EMBASE, Medline-ProQuest, and Google Scholar incorporating the keywords "frailty" and "vasculitis" to identify relevant indexed full articles and conference abstracts (Supporting Information: Table S1). [4][5][6][7][8][9] Primarily, published studies aimed to determine the prevalence of frailty among older AAV patients, to address whether a more severe frailty status indicated worse AAV-associated outcomes including complication rates, and to determine if the perceived frailty status of older AAV patients improved with immunosuppressive treatment. These studies utilized various frailty assessment tools, allowing for comparisons to be made in relation to the application of frailty assessment tools within this context.…”